Since the early 1980s, the number of vaccines given to children has nearly quadrupled, and the autism rate has gone up more than 30,000 percent during the same period. For American children, the current autism rate is 1 in 36. JB Handley challenges the common framing that vaccines are "safe and effective" and that the "science is settled. He discusses the emerging scientific evidence linking vaccines to immune activation in the brain. He calls for the American public health to acknowledge the adverse effects associated with vaccines and advocates for screening vulnerable children so that the children with the greatest risk for vaccine associated harm can be excused from taking the vaccine