On today’s episode of Making Sense of Science, I’m honored to be joined by Dr. Paul Song, a physician, oncologist, progressive activist and biotech chief medical officer. Through his company, NKGen Biotech, Dr. Song is leveraging the power of patients’ own immune systems by supercharging the body’s natural killer cells to make new treatments for Alzheimer’s and cancer. 

Whereas other treatments for Alzheimer’s focus directly on reducing the build-up of proteins in the brain such as amyloid and tau in patients will mild cognitive impairment, NKGen is seeking to help patients that much of the rest of the medical community has written off as hopeless cases, those with late stage Alzheimer’s. And in small studies, NKGen has shown remarkable results, even improvement in the symptoms of people with these very progressed forms of Alzheimer’s, above and beyond slowing down the disease.

In the realm of cancer, Dr. Song is similarly setting his sights on another group of patients for whom treatment options are few and far between: people with solid tumors. Whereas some gradual progress has been made in treating blood cancers such as certain leukemias in past few decades, solid tumors have been even more of a challenge. But Dr. Song’s approach of using natural killer cells to treat solid tumors is promising. You may have heard of CAR-T, which uses genetic engineering to introduce cells into the body that have a particular function to help treat a disease. NKGen focuses on other means to enhance the 40 plus receptors of natural killer cells, making them more receptive and sensitive to picking out cancer cells. 

Dr. Song is the grandson of the late Sang Don Kim, who was the first popularly elected Mayor of Seoul, South Korea. Dr. Song serves as the co-chair for a Campaign for a Healthy California. In 2013, he was named and served as the very first visiting fellow on healthcare policy in the California Department of Insurance. In addition, Dr. Song serves on the executive board of Physicians for a National Health Program California, People for the American Way, Progressive Democrats of America, Healthcare NOW, The Eisner Pediatric and Women's Center, and the Asian Pacific American Institute for Congressional Studies. Dr. Song graduated with honors from the University of Chicago, received his M.D. from George Washington University and completed his residency in radiation oncology at the University of Chicago. He sees Medicaid and uninsured patients at Dignity California Hospital.

With Dr. Song’s leadership, NKGen’s work on natural killer cells represents cutting-edge science that’s resulting in key findings about two of humanity’s most intractable diseases – contributing important pieces of the puzzle for treating them.

Making Sense of Science features interviews with leading medical and scientific experts about the latest developments in health innovation and the big ethical and social questions they raise. The podcast is hosted by science journalist Matt Fuchs