Dr. Rachel Blair, an endocrinology fellow at Brigham and Women’s Hospital, joins Dr. Navin Kumar (host) and Sarah Onorato (case presenter) to discuss hypothyroidism. Together, they use a sample case of a patient with hypothyroidism as a framework to guide discussion about primary vs. secondary hypothyroidism, associated lab findings, and management of unambiguous hypothyroidism vs. subclinical hypothyroidism. They wrap up their discussion with several clinical pearls, advocating for both a broad differential and panel of lab studies, assessed over time, to cinch the diagnosis.