Children have been less impacted by the pandemic than adults, but its direct and indirect effects still have been significant. Additionally, a newly identified hyperinflammatory syndrome, MIS-C, has caused multisystem critical illness in some children. In this episode, an expert panel reviews the impacts of COVID-19 on children, including the clinical manifestations and potential etiologies of MIS-C and the indirect effects of the pandemic. (Originally recorded April 29, 2021) Moderator: Ken Remy, MD. Panelists: Adrienne Randolph, MD; Yonca Bulut, MD; and Janine Zee-Cheng, MD. For more tools to help in the fight against COVID-19, visit CHEST’s COVID-19 Resource Center at chestnet.org/COVID19.