Incubation

Why do we all know so little about the Herpes Simplex Virus (HSV), despite the fact that herpes infections are common and chronic? First, we get some Herpes 101 from researcher Anna Wald. Then, we speak with Ella Dawson, a sex and culture critic who is one of the billions of people living with HSV–1.

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What can the mythical jackalope teach us about HPV? Author Michael Branch tells the story of how scientists first discovered horned rabbits, and how their findings paved the way for the study of all different kinds of papilloma viruses. Then, Elena Conis joins the shows to discuss the rollout of the human papilloma virus (HPV) vaccine in the US and Americans’ complicated relationship with vaccine mandates.

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What risk does H5N1 pose to humans? We hear from David Quammen, author of “Spillover,” about the vast and complicated interplay between influenza, the environment, animals, and humans. Then, molecular virologist Wendy Puryear helps us understand why seals on a remote island can be an early warning system.

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What do we know – and not know – about the suite of viral infections known as “the common cold”? We speak with curator Katie Dabin about the UK’s Common Cold Unit, where volunteers signed up over the course of decades to get infected with colds. Then we enlist top virologist Gary McLean for some advice on what we can do to help ourselves feel better.

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What is ‘structure-based’ vaccine design? Before scientists used these techniques to design vaccines against Covid, they were testing them in the lab to combat RSV. Keren Landman joins the show to talk about how this respiratory virus endangers the lives of babies and the elderly. Then, we hear about an early RSV vaccine trial that cast a shadow over modern research, and how scientists, including our guests Jason McLellan and Barney Graham, later figured out how to create and stabilize a viral antigen’s spike protein to fight RSV.

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Why has polio been so challenging to eradicate? Karen Torghele tells the story of two polio vaccines and the two rival scientists who developed them: Albert Sabin and Jonas Salk. Then, Dr. Ananda S Bandyopadhyay explains our best bet for eliminating the disease worldwide.

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What can we learn from the centuries-long quest to eradicate smallpox, once the scourge of humanity? And how did it set the stage for all vaccines to come? First we meet Edward Jenner, a doctor in 18th century Britain who learned about the folk practice of “variolation” and found a safer way to inoculate people against smallpox. Then, Donald Hopkins of the Carter Center takes us back to the 1960s in Sierra Leone, where he discovered that successfully eradicating smallpox could be a feasible goal worldwide.

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A new podcast that traces the history of humanity through viruses. New episodes weekly starting September 7.

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