The largest commercial autonomous system on earth isn't a robotaxi fleet — it's Zipline, which has flown 140 million autonomous miles with zero safety incidents. Co-founder Keller Rinaudo Cliffton and Eric Watson, who leads systems engineering and safety, explain why the drone itself is only 15% of the solution. The rest spans inventory management, air traffic integration, and engineering systems such as a dual flight computer failover protocol that recently saved a delivery mid-flight. They trace Zipline's path from launching blood delivery in Rwanda in 2016 (when drone delivery was illegal in the US) to a 51% reduction in maternal mortality in that country, a $550 million commercial diplomacy partnership with the State Department, and a cost curve that fell from $300 per delivery to $12. Zipline is now racing toward a million deliveries a day, and a quiet inflection point when autonomous delivery becomes cheaper than sending a car.

Hosted by Alfred Lin and Pat Grady, Sequoia Capital