Dr Livingston, MD, provides summary and commentary on the March 7, 2012 issue of JAMA, the Journal of the American Medical Association. Early Surgical Therapy for Drug-Resistant Epilepsy, Testosterone Effect on Fat-Free Mass in Men, Mental Health Disorders and Opioid Use, Bevacizumab in Hereditary Hemorrhagic Telangiectasia, Use of Quality Indicators in Patient Care, Retreat from advanced care planning, Provocative principles for health care reform.