Dr Bauchner, Editor in Chief of JAMA, provides summary and commentary on the April 4, 2012 issue of JAMA, the Journal of the American Medical Association. Cetuximab and Stage III Colon Cancer Survival, Screening Ultrasound or MRI for Breast Cancer, Diagnostic Coding and Trends in Pneumonia Outcomes, Fluoroquinolones and Risk of Retinal Detachment, Management of Ovarian Cancer, Financial incentives in health care, Individualized breast cancer treatment.