Please visit answersincme.com/ZVJ860 to participate, download slides and supporting materials, complete the post test, and obtain credit. In this activity, an expert in the management of metastatic colorectal cancer (mCRC) discusses treatment strategies to enhance patient outcomes during later-line therapy. Upon completion of this activity, participants should be better able to: Identify guideline recommendations for later-line treatments for patients with mCRC; Describe recent evidence for later-line treatments for patients with mCRC, including evidence informing treatment sequencing; and Review evidence-based, patient-centered approaches to manage adverse events for patients with mCRC receiving later-line treatment.