Please visit answersincme.com/MNK860 to participate, download slides and supporting materials, complete the post test, and obtain credit. In this activity, experts in hematology-oncology discuss strategies for the use of novel tyrosine kinase inhibitors (TKIs) in the management of patients with newly diagnosed chronic-phase chronic myeloid leukemia (CP-CML). Upon completion of this activity, participants should be better able to: Identify the clinical rationale for using novel TKIs for newly diagnosed CP-CML; Discuss the clinical implications of the latest data for first-line novel TKIs in CP-CML; and Outline potential considerations to optimize outcomes for newly diagnosed patients with CP-CML on first-line TKIs.