With the House and Senate on break, President Joe Biden will be at the center of political coverage this week — and the three big Biden stories are Afghanistan, Covid-19 and infrastructure.

All three issues share something in common: They are monumental policy and political challenges with enormous long-term consequences for America (and the world). Six months into his presidency, there has been major progress on all three issues, but no final resolution. In each case, a reversal of fortunes or outright failure is still possible.

Raghu Manavalan is the host of POLITICO's Playbook.
Jenny Ament is the senior producer for POLITICO Audio. 
Irene Noguchi is the executive producer of POLITICO Audio.