As a Stanford Biodesign Innovation Fellow, Kate Rosenbluth was captivated by the unmet need to treat hand tremors. She discovered that the site of deep brain stimulation was accessible through the peripheral nerves in the wrist, and teamed up with Scott Delp, director of the Stanford Neuromuscular Biomechanics Lab, to found Cala Health, where she is now the chief scientific officer. The company’s wearable neuromodulation therapies merge neuroscience research with cutting-edge technology to deliver individualized peripheral nerve stimulation. Here, she presents a framework for “needs-based innovation,” and explores how she emphasized a needs-based approach in the context of Cala Health.