Dr. Casey Grover explores the complexities of ketamine, examining its medical benefits, potential for addiction, and growing presence in both therapeutic and recreational settings.

• Originally developed as a dissociative anesthetic for surgery that doesn't suppress breathing
• Now recognized for treating treatment-resistant depression, PTSD, and suicidal ideation
• Can reduce suicidal thoughts as quickly as 90 minutes after administration
• Also effective for severe pain, alcohol withdrawal, and certain emergency situations
• Recreational use has increased dramatically with seizures up 350% between 2017-2022
• Creates a trance-like "K-hole" state that users seek for altered perception and relaxation
• Long-term use can cause "ketamine bladder" – potentially requiring surgical intervention
• No FDA-approved medications exist specifically for treating ketamine addiction
• For-profit ketamine clinics often charge $500-1,250 per treatment without comprehensive care
• Matthew Perry's death highlights the dangers of ketamine misuse, even under medical supervision
• Most patients with addiction histories should approach ketamine therapy with extreme caution

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To contact Dr. Grover: [email protected]