After finding success with Bone Thugs-n-Harmony, Krayzie Bone recorded his solo debut, Thug Mentality 1999, in 1999. The album was released as a double disc set, featuring a large selection of guest appearances, including Bone Thugs-n-Harmony, Mo Thugs, Mariah Carey, ThugLine, The Marley Brothers, Big Pun, Fat Joe, Cuban Link, Gangsta Boo, E-40, 8 Ball & MJG, Kurupt, Naughty By Nature and Snoop Dogg. The album was largely produced by multi instrumentalist Romeo Antonio and was certified platinum by the RIAA.

In 2001, Krayzie Bone released Thug On Da Line, which received generally positive reviews from music critics and went gold.

In 2005 Krayzie Bone was featured in the song "Ridin'" by Chamillionaire. "Ridin'" was awarded "Best Rap Performance by a Duo or Group" at the 49th Annual Grammy Awards. It was also nominated for Best Rap Song. It became number one in December on the Pop Chart 3 months after its physical release. The song also topped the Billboard Hot 100 and peaked at number 2 on the UK Singles Chart when it was released there. The song ranked #3 on Rolling Stone's "100 Best Songs of 2006" and #91 on VH1's "100 Greatest Songs of Hip Hop". It was the best selling ringtone in 2006, with 3.2 million sales, certified by the RIAA as the first multi-platinum Mastertone artist in history. It was also awarded the last Best Rap Video at the MTV Video Music Awards, which was awarded in 2006.

Krayzie Bone comes from a fourth generation family of Jehovah's Witnesses, and as such does not celebrate Christmas. He believes many rappers are unintentionally following the agenda of the Illuminati.[9]

On September 24, 2023, Krayzie Bone was admitted to a hospital in Los Angeles after coughing up blood in his sleep, what was later attributed to sarcoidosis. Doctors were unsuccessful in an emergency surgery. On September 26, he was sedated due to a main artery in his lung leaking. However, on October 3, he announced he had recovered from the ailment.

Krayzie Bone also has a thriving foundation called "Spread The Love" that mentors and teaches at risk youth life skills and about the music business.

Learn more about your ad choices. Visit megaphone.fm/adchoices