Somehow we got through 7 articles today, and none of them are about COVID-19!

Happy Thanksgiving!

Chlorthalidone in CKD

Milvexian for VTE Prevention

Risk of Recurrent VTE in Subsegmental PE

Rivaroxaban associated with higher rates of GI bleeding

Depression and Residency

Mental-Stress Induced Myocardial Ischemia

Patient Outcomes for Part Time Hospitalists







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Today we talk about the effect of eliminating the race coefficient from the estimated GFR calculators, the risk of bleeding from anticoagulation after first unprovoked VTE, another trial looking at therapeutic anticoagulation in COVID-19, and whether 12 mg of dexamethasone is better than 6 mg for severe COVID-19 infections.


New GFR Equations without Race

Race, Genetic Ancestry and Estimating Kidney Function

Long Term Bleeding Risk from Oral AC after First Unprovoked VTE

Therapeutic Heparin for COVID-19 (HEP-COVID)

High Dose Dexamethasone for Severe COVID-19




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1. We're back after a nice relaxing summer taking care of a surge of COVID-19 patients.  To start off season 3 we decided to do a rapid review of some of the best articles over the last three months.  Dr. Brian Locke returns to help us break down some critical care papers, we talk about the miracle of SGLT-2 inhibitors, the treatment of UTIs in men, and the latest in COVID-19 literature. 

Hypothermia vs Normothermia after Cardiac Arrest

Empagliflozin for Heart Failure with Preserved EF

Antibiotic Duration for Afebrile UTIs in Men

Normal Saline vs Balanced Solution in ICU patients

Baricitinib for COVID-19

Therapeutic Anticoagulation for COVID-19














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Today is our season 2 finale, and we have a master class on prosthetic joint infections from Dr. Laura Certain.  Is 6 weeks as good as 12 weeks for prevent recurrent infections?  How does the surgeon decide what kind of surgery to do?  Should we use oral or IV antibiotics?  When should you use rifampin??  Dr. Certain answers all these questions and more.

We also talk about the new colon cancer screening guidelines from USPSTF, hospital admission for chest pain after ACS ruled out in the ED, whether morning discharges improve patient throughput, and a study looking at personalized steroid dose for COPD exacerbations.

We will be back in the fall of 2021! 

Antibiotics for Prosthetic Joint Infections
Colorectal Cancer Screening
Hospital Admission for Chest Pain after ACS Ruled Out
Morning Discharges and LOS
Personalized Steroid Regimen for COPD exacerbation





Music from https://filmmusic.io
"Sneaky Snitch" by Kevin MacLeod (https://incompetech.com)
License: CC BY (http://creativecommons.org/licenses/by/4.0/)

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How long can you delay antibiotics in patients with suspected sepsis before the risk of hospital mortality increases?  What proportion of patients with suspected sepsis end up having actual sepsis?  Dr. Devin Horton joins us to review a paper in Critical Care Medicine that tries to answer these questions. 

Antibiotic Delay Intervals and Hospital Mortality for Patients with Suspected Sepsis
High Flow Nasal Oxygen
POCUS for Acute Dyspnea
Screening of Atrial Fibrillation in Older Patients








Music from https://filmmusic.io
"Sneaky Snitch" by Kevin MacLeod (https://incompetech.com)
License: CC BY (http://creativecommons.org/licenses/by/4.0/)

Music from Uppbeat (free for Creators!):

https://uppbeat.io/t/soundroll/dope

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Today we have special guest Dr. Natalie Como to talk about Hospital at Home and what it's like to practice hospital medicine at a rural critical access hospital.  We also look at a retrospective paper on ACE/ARBs in veterans with pulmonary hypertension and talk about vaccine-induced immune thrombotic thrombocytopenia (VITT).  Check it out!

Hospital at Home with Comprehensive Geriatric Assessment
RAAS Inhibition and Pulmonary Hypertension
Vaccine-Induced Immune Thrombotic Thrombocytopenia 










Music from https://filmmusic.io
"Sneaky Snitch" by Kevin MacLeod (https://incompetech.com)
License: CC BY (http://creativecommons.org/licenses/by/4.0/)

Music from Uppbeat (free for Creators!):

https://uppbeat.io/t/soundroll/dope

License code: NP8HLP5WKGKXFW2R

Today we are joined by heavy hitter Dr. Brian Locke to talk about the new paper on 3 vs 8 days of antibiotics for pneumonia, a clever new paper looking at whether there is any association between IV contrast and kidney function, and a new retrospective study on DOAC use for valvular atrial fibrillation.  Check it out!


Three Days of Antibiotics for Pneumonia
IV Contrast and Kidney Function
DOACs for Valvular Atrial Fibrillation





Music from https://filmmusic.io
"Sneaky Snitch" by Kevin MacLeod (https://incompetech.com)
License: CC BY (http://creativecommons.org/licenses/by/4.0/)

Music from Uppbeat (free for Creators!):

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Today we are doing double duty: podcasting and parenting.  Fortunately our babies were well-behaved.  We talk about three trials for semaglutide and weight loss and a new 4 level pre-test probability rule for diagnosing PE.  We also talk about a retrospective study of cefazolin vs nafcillin for epidural abscess, a ferritin/procalcitonin ratio for differentiating bacterial from COVID pneumonia, and a new randomized controlled trial of intermediate thromboprophylaxis for ICU patients with COVID19.  Check it out!


Semaglutide for Weight Loss (STEP 1)
Semaglutide for Weight Loss in Diabetics (STEP 2)
Semaglutide + Intensive Calorie Restriction for Weight Loss (STEP 3)

4PEPS for Pulmonary Embolism
Nafcillin vs Cefazolin for Epidural Abscess
Ferritin/Procalcitonin Ratio for COVID-19 vs Bacterial Pneumonia
Intermediate Thromboprophylaxis for COVID-19 (INSPIRATION)








Music from https://filmmusic.io
"Sneaky Snitch" by Kevin MacLeod (https://incompetech.com)
License: CC BY (http://creativecommons.org/licenses/by/4.0/)

Hall of the Mountain King Kevin MacLeod (incompetech.com)
Licensed under Creative Commons: By Attribution 3.0 License
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Today has a nice liver disease theme.  Does targeting a serum albumin above 3 g/dL reduce death, infections and kidney failure in patients with decompensated cirrhosis?  Does terlipressin work in hepatorenal syndrome? 


Albumin Infusion for Decompensated Cirrhosis
Terlipressin for Type 1 Hepatorenal Syndrome 







Music from https://filmmusic.io
"Sneaky Snitch" by Kevin MacLeod (https://incompetech.com)
License: CC BY (http://creativecommons.org/licenses/by/4.0/)

Music from Uppbeat (free for Creators!):

https://uppbeat.io/t/soundroll/dope

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Today I am joined by Infectious Disease expert Dr. Emily Spivak to talk about the latest batch of tocilizumab trials for COVID-19 and a meta-analysis of all the convalescent plasma trials.  Check it out!


Tocilizumab in Hospitalized Patients with COVID-19 (COVACTA)
IL-6 Receptor Antagonists in Critically Ill Patients with COVID-19 (REMAP-CAP)
RECOVERY Tocilizumab pre-print
Meta-analysis of Convalescent Plasma for COVID-19










Music from https://filmmusic.io
"Sneaky Snitch" by Kevin MacLeod (https://incompetech.com)
License: CC BY (http://creativecommons.org/licenses/by/4.0/)

Music from Uppbeat (free for Creators!):

https://uppbeat.io/t/soundroll/dope

License code: NP8HLP5WKGKXFW2R