This episode delves into the complex world of substance use disorder, exploring its neurobiology, types, and special needs of patients affected by the condition. We discuss the physiological and psychological effects of commonly misused drugs, the role of drug-assisted treatments during toxicity, withdrawal, and abstinence, and how nurses can support patients through the management of both surgical experiences and pain in those with substance use disorder. This episode also examines the unique challenges faced by healthcare providers, including nurses, who struggle with substance use disorder themselves. We explore the Beers Criteria, polypharmacy, and best practices for promoting health teaching, prevention, and care in a patient-centered collaborative framework.