Lethal Dose

Lethal Dose

By Kayla Woods and Venus de NekoTrue Crime
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Lethal Dose episodes

  • Episode 40: Paraquat

    In 1985, bottles of Oronamin C containing the herbicide paraquat poisoned 35 people in Japan and killed 12, but that's just the tip of the iceberg when it comes to the paraquat problem.

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    Ajdacic-Gross, V., Weiss, M. G., Ring, M., Hepp, U., Bopp, M., Gutzwiller, F., & Rössler, W. (2008). Methods of suicide: international suicide patterns derived from the WHO mortality database. Bull World Health Organ, 86(9), 726-732.

    Burgoyne, J. (2023). Paraquat Lawsuit Update March 2023. Forbes Advisor. Retrieved 13 Apr 2023, from https://www.forbes.com/advisor/legal/product-liability/paraquat-lawsuit/

    Company History. (2023). Retrieved 13 Apr 2023 from https://www.syngenta.com.eg/company-history

    Dowler, C., & Gaberell, L. (2021). The Paraquat Papers: How Syngenta's bad science helped keep the world's deadliest weedkiller on the market. Unearthed. Retrieved 11 Apr 2023, from https://unearthed.greenpeace.org/2021/03/24/paraquat-papers-syngenta-toxic-pesticide-gramoxone/

    Eddleston, M., Nagami, H., Lin, C.-Y., Davis, M. L., & Chang, S.-S. (2022). Pesticide use, agricultural outputs, and pesticide poisoning death in Japan. Clin Tox, 60(8), 933-941.

    Gillam, C. (2021). 'A sip can kill': did a chemical company misrepresent data to avoid making a safer product? The Guardian. Retrieved 13 Apr 2023, from https://www.theguardian.com/environment/2021/mar/24/syngenta-paraquat-deadly-john-heylings

    Gunnell, D., Knipe, D., Chang, S.-S., Pearson, M., Konradsen, F., Lee, W. J., & Eddleston, M. (2017). Prevention of suicide with regulations aimed at restricting access to highly hazardous pesticides: a systematic review of the international evidence. The Lancet, 5(10), E1026-1037.

    Haberman, C. (1985, 10 Dec 1985). Japanese Puzzle: The Vending Machine Murders. The New York Times. https://timesmachine.nytimes.com/timesmachine/1985/12/10/issue.html

    Lerner, S. (2021). The Paraquat Poisoning Problem. The Intercept_. Retrieved 19 Mar 2023, from https://theintercept.com/2021/03/24/paraquat-poisoning-syngenta/

    Nadrich, J. (2021). The Paraquat Vending Machine Murders. Retrieved 19 Mar 2023 from https://personalinjurylawcal.com/blog/the-paraquat-vending-machine-murders/

    Nagami, H., Maejima, F., Nishigaki, Y., & Natsukawa, S. (2013). Trends in paraquat poisoning in Japan - Viewed from surveys on clinical cases. J Rural Med, 8(2), 228-232.

    Okabe, M. (1985). Japanese warned against poisoned soft drinks. UPI. Retrieved 19 Mar 2023, from https://www.upi.com/Archives/1985/09/27/Japanese-warned-against-poisoned-soft-drinks/9882496641600/

    Sukumar, C. A., Shanbhag, V., & Shastry, A. B. (2019). Paraquat: The Poison Potion. Indian H Crit Care Med, 23, S263-266.

    Wilks, M. F., Fernando, R., Ariyananda, P. L., Eddleston, M., Berry, D. J., Tomenson, J. A., Buckley, N. A., Jamamanne, S., Gunnell, D., & Dawson, A. (2008). Improvement in survival after paraquat ingestion folloiwing introduction of a new formulation in Sri Lanka. PLoS Med, 5(2), e49.

    Yamashita, M., Yamashita, M., & Ando, Y. (2000). A long-term follow-up of lung function in survivors of paraquat poisoning. Human Exp Toxicol, 19, 99-103.

    Yang, C.-J., Lin, J.-L., Lin-Tan, D.-T., Weng, C.-H., Hsu, C.-W., Lee, S.-Y., Lee, S.-H., Chang, C.-M., Lin, W.-R., & Yen, T.-H. (2012). Spectrum of toxic hepatitis following intentional paraquat ingestion: analysis of 187 cases. Liver Int., 32(9), 1400-1406.

    Yates, R. E. (1985). New Spate of Poisonings Terrifies Japan. Chicago Tribune. Retrieved 19 Mar 2023, from https://www.chicagotribune.com/news/ct-xpm-1985-10-27-8503130469-story.html

    46 min
  • Episode 39: Serotonin

    The happy chemical might not be the happy chemical after all, and it could actually kill you. Libby Zion probably didn't know this back in 1984, but her doctors should have.

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    Albert, P. R., Benkelfat, C., & Descarries. (2012). The neurobiology of depression—revisiting the serotonin hypothesis. I. Cellular and molecular mechanisms. Phil Trans R Soc B, 367, 2378-2381.

    Classen, D. C., Resar, R., Griffin, F., Federico, F., Frankel, T., Kimmel, N., Whittington, J. C., Frankel, A., Seger, A., & James, B. C. (2011). ‘Global Trigger Tool’ Shows That Adverse Events In Hospitals May Be Ten Times Greater Than Previously Measured. Health Affairs, 30(4), 581-589.

    Cohen, S. (2014). The Lasting Legacy of a Case that was "Lost". Penn State Law Review. Retrieved 07 Mar 2023, from https://www.pennstatelawreview.org/penn-statim/the-lasting-legacy-of-a-case-that-was-lost/

    Coppen, A. (1967). The Biochemistry of Affective Disorders. Brit J Psych, 113(504), 1237-1264.

    Cowen, P. J., & Browning, M. (2015). What has serotonin to do with depression? World Psych, 14(2), 158-160.

    Drugs Interaction Checker. https://www.webmd.com/interaction-checker/default.htm

    Harmer, C. J., Duman, R. S., & Cowen, P. J. (2017). How do antidepressants work? New perspectives for refining future treatment approaches. Lancet Psych, 4(5), 409-418.

    Healy, D. (2015). Serotonin and depression. BMJ, 350, h1771.

    Hoffman, J. (1995, 02 May 1995). Judge Sets Aside Use of Cocaine as Part of Verdict in Zion Case. The New York Times.

    Lerner, B. H. (2009). A Life-Changing Case for Doctors in Training. The New York Times. Retrieved 12 Mar 2023, from https://www.nytimes.com/2009/03/03/health/03zion.html

    Nardil® (Phenelzine Sulfate Tablets, USP). In FDA (Ed.), FDA. accessdata.fda.gov.

    Oura, P., & Sajantila, A. (2022). A recent two-fold increase in medical adverse event deaths among US inpatients. J Public Health Res, 11(4), 1-4.

    Robins, N. (1995). The Girl Who Died Twice. Delacorte Press.

    Serotonin. (2022). Cleveland Clinic. Retrieved 13 Mar 2023 from https://my.clevelandclinic.org/health/articles/22572-serotonin#:~:text=Serotonin%20is%20a%20chemical%20that,blood%20clotting%20and%20sexual%20desire.

    Valkonen, V., Haatainen, K., Saano, S., & Tiihonen, M. (2023). Evaluation of Global trigger tool as a medication safety tool for adverse drug event detection—a cross‑sectional study in a tertiary hospital. Eur J Clin Pharma. https://doi.org/https://doi.org/10.1007/s00228-023-03469-5

    Volpi-Abadie, J., Kaye, A. M., & Kaye, A. D. (2013). Serotonin Syndrome. Ochsner J, 13(4), 533-540.

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    1 hr 46 min
  • Episode 38: The Teacup Poisoner

    The Teacup Poisoner was a chemistry bro/edge lord serial killer (aren't they all?) responsible for the murder of at least three people with thallium, but that wasn't his only poison of choice.

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    Attack on schistosomiasis. (1966). BMJ,

    1(5482), 249-250.

    Emsley, J. (2005). The Elements of Murder. Oxford University Press.

    Genchi, G., Carocci, A., Lauria, G.,

    Sinicropi, M. S., & Catalano, A. (2021). Thallium use, toxicity, and
    detoxification therapy: An overview. Appl.
    Sci., 11(18).

    Holden, A. (1974). The St Albans Poisoner. Corgi Books.

    Mari, M., & Domingo, J. L. (2010).

    Toxic emissions from crematories: A review. Environ
    Int., 36(1), 131-137.

    McCallum, R. I. (1977). Observations

    upon antimony. Proc Roy Soc Med, 70, 756-763.

    Periferakis, A., Caruntu, A.,

    Periferakis, A.-T., Scheau, A.-E., Badarau, I. A., Caruntu, C., & Scheau,
    C. (2022). Availability, toxicology and medical significance of antimony. Int J Environ Res Public Health, 19(8).

    Sundar,

    S., & Chakravarty, J. (2010). Antimony toxicity. Int J Environ Res Public Health,
    7(12), 4267-4277.

    ----


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    1 hr 20 min
  • Episode 37: PFAS Pt. 3 Forever Chemicals

    In this conclusion to our series on PFAS chemicals, Venus and Kayla discuss the current status of PFAS regulations around the world, where they have been detected, and how they impact all of us.


    Find references for this episode over at patreon.com/lethaldosepod (for free!) and at Kayla's blog, writerkaylawoods.wordpress.com.

    You can also support us by subscribing to ad-free content on Spotify for $0.99, or subscribing on Patreon at the $2 or $5 level and also get bonus content.

    If you like the show, leave us a rating or a review, and/or share it with a friend! Every little thing helps to get the word out and help us find our people.


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    Instagram: https://www.instagram.com/lethaldosepod/

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    54 min
  • Episode 36: PFAS Pt. 2 Do the Study After We Are Sued

    We continue the story of PFAS by examining the fallout from the 1999 lawsuit brought against DuPont by Wilbur Tennant and lawyer Rob Bilott. Both 3M and DuPont knew that their chemicals were dangerous for far longer than they ever have admitted, and regular people have paid the price with their health and their lives.

    Find references for this episode over at patreon.com/lethaldosepod (for free!) and at Kayla's blog, writerkaylawoods.wordpress.com.

    You can also support us by subscribing to ad-free content on Spotify for $0.99, or subscribing on Patreon at the $2 or $5 level and also get bonus content.

    If you like the show, leave us a rating or a review, and/or share it with a friend! Every little thing helps to get the word out and help us find our people.

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    59 min
  • Episode 35: PFAS Pt. 1 Decades of Deceit

    The history of per- and polyfluoroalkyl substances stretches back to the Manhattan Project. In this episode, we cover discovery of PFAS and their use at major companies like 3M and DuPont up to their contamination of a cattle pasture in West Virginia that brought their toxicity into the eyes of the public.

    Find references for this episode over at patreon.com/lethaldosepod (for free!) and at Kayla's blog, writerkaylawoods.wordpress.com.

    You can also support us by subscribing to ad-free content on Spotify for $0.99, or subscribing on Patreon at the $2 or $5 level and also get bonus content.

    If you like the show, leave us a rating or a review, and/or share it with a friend! Every little thing helps to get the word out and help us find our people.

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    Instagram: https://www.instagram.com/lethaldosepod/

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    1 hr
  • Episode 34: Dr. Hawley Crippen

    Season 5 opens with the case of trial by media in the suspected murder of Cora Crippen in 1910. In the end, there are more questions than answers, and an innocent man stands accused.

    Ask Crippen's Reprieve. (1910, 18 Nov 1910). The New York Times.

    Burney, I., & Pemberton, N. (2010). The rise and fall of celebrity pathology. BMJ, 341(7786), 1319-1321.

    Corallo, C. E., Whitfield, A., & Wu, A. (2009). Anticholinergic syndrome following an unintentional overdose of scopolamine. Ther Clin Risk Manag, 5, 719-723.

    Crippen's Father Dies. (1910, 19 Nov 1910). The New York Times.

    Crippen's Father Talks. (1910, 15 Jul 1910). The New York Times.

    Executed in Error. (2008). youtube.com, PBS. https://www.youtube.com/watch?v=y2qzyVT-DyQ

    Foran, D. R., Wills, B. E., Kiley, B. M., Jackson, C. B., & Trestrail, J. H. I. (2010). The conviction of Dr. Crippen: New forensic findings in a century-old murder. J Forensic Sci, 8. https://doi.org/10.1111/j.1556-4029.2010.01532.x

    Gives Crippen Alias, Too. (1910, 22 Aug 1910). The New York Times.

    Grief of Crippen's Father. (1910, 02 Aug 1910). The New York Times.

    Hawley Crippen. (2008). PBS. Retrieved 17 Dec 2022 from https://www.pbs.org/wnet/secrets/hawley-crippen/199/

    Hodgson, M. (2007). 100 years on, DNA casts doubt on Crippen case. The Guardian. Retrieved 18 Dec 2022, from https://www.theguardian.com/uk/2007/oct/17/ukcrime.science

    Keys, T. E. (1996). "Twilight" Sleep. In The History of Surgical Anesthesia. Wood Library-Museum of Anesthesiology.

    McVey, W. M. B. (1894). Chemical importance of the ptomaines or cadaveric alkaloids in medicolegal analysis. Boston Med Surg J, 131, 458-460.

    Moore, A. D., Towghi, F., Ashford, H. R., Dune, T., & Pithavadian, R. (2021). The global proliferation of radical gynaecological surgeries: A history of the present. Hist and Anthro, 25. https://doi.org/10.1080/02757206.2021.1987232

    Race Over Ocean to Catch Crippen. (1910, 24 Jul 1910). The New York Times.

    Riad, M., & Hithe, C. C. (2022). Scopolamine. StatPearls. https://www.ncbi.nlm.nih.gov/books/NBK554397/

    Says Mrs. Crippen is Alive. (1910, 07 Nov 1910). The New York Times.

    Smith, D. J. (2005). Supper with the Crippens. Orion Books.

    Woman Thought to Be Belle Elmore Found. (1910, 13 Nov 1910). Los Angeles Herald.

    Young, F. (Ed.). (1991). The Trial of Hawley Harvey Crippen. The Notable Trials Library.

    1 hr 24 min
  • Episode 33: Aum Shinrikyo Pt. 3 The Tokyo Subway Attack

    The story of Aum Shinrikyo culminates in the infamous attack on the Tokyo subway with sarin gas and then weeks of raiding Aum facilities and years of trials. This is also our last episode of season 4; we will return in 2023 with season 5! Check us out on social media until then, or find us on Patreon!


    Fackler, M. (2012). Tokyo Gas Attack Arrest Reawakens National Trauma. The New York Times. Retrieved 07 Dec 2022, from https://www.nytimes.com/2012/06/08/world/asia/tokyo-gas-attack-arrest-reawakens-national-trauma.html 

    Faith in Aum guru resurges as Joyu moves to form his own group. (2007). Religion News Blog. https://www.religionnewsblog.com/17375/aum-shinrikyo-3

    Former Aum Shinrikyo cult spokesman sets up new group. (2007). Religion News Blog. https://www.religionnewsblog.com/18181/hikari-no-wa

    Griffiths, J. (2018). Japanese cult leader Shoko Asahara executed for Tokyo sarin attack. CNN. Retrieved 06 Dec 2022, from https://www.cnn.com/2018/07/05/asia/japan-aum-shinriyko-leader-executed-intl/index.html 

    Gunaratna, R. (2018). Aum Shinrikyo's Rise, Fall and Revival. Counter Terrorist Trends and Analyses, 10(8), 1-6. 

    Japanese Ruling Rejects Banning of Cult. (1997, 01 Feb 1997). The New York Times. 

    Kageyama, Y. (1998). Japanese Cult Member Gets Life. Retrieved 06 Dec 2022, from https://apnews.com/article/9004eccd45b75e01c26f65291d658601 

    Kaplan, D. E., & Marshall, A. (1996). The Cult at the End of the World. Crown Publishers, Inc. 

    Kristof, N. D. (1995a, 27 Apr 1995). Japan Police Arrest 2 Found Beneath Sect Headquarters. The New York Times, 1, 11. 

    Kristof, N. D. (1995b, 26 Oct 1995). Japanese Cult Leader Dismisses Lawyer, Gaining Delay in Trial. The New York Times. 

    Kristof, N. D. (1995c, 07 Jun 1995). Japanese Indict Leader of Cult in Gas Murders. The New York Times. 

    Kristof, N. D. (1995d, 07 May 1995). Japanese Police Foil Gas Attck in Subway. The New York Times. 

    Kristof, N. D. (1995e, 31 Oct 1995). Tokyo Court Orders Disbanding of Sect in Subway Nerve Gas Case. The New York Times. 

    Kristof, N. D. (1996, 08 Nov 1996). Tokyo Suspect in Subway Raid Erupts in Court. The New York Times. 

    Kuchikomi. (2012). Aum spinoffs still out there, and as devious as ever. Japan Today. Retrieved 07 Dec 2022, from https://japantoday.com/category/features/kuchikomi/aum-spinoffs-still-out-there-and-as-devious-as-ever 

    Murakami, H. (2003). Underground (A. Birnbaum & P. Gabriel, Trans.). Vintage 

    Onishi, N. (2004). After 8-Year Trial in Japan, Cultist is Sentenced to Death. The New York Times. Retrieved 07 Dec 2022, from https://www.nytimes.com/2004/02/28/world/after-8-year-trial-in-japan-cultist-is-sentenced-to-death.html 

    Pollack, A. (1995, 07 Sep 1995). Japanese Police Find Body of a Lawyer Believed Killed by Cult. The New York Times. 

    Sims, C. (1999a, 03 Nov 1999). Japan Drafts Bill to Control Some Cults By Year's End. The New York Times. 

    Sims, C. (1999b, 12 Sep 1999). To Get Cult To Leave, Japan Cities Buy It Out. The New York Times. 

    Sims, C. (2000, 28 Feb 2000). Under Fire, Japan Sect Starts Over. The New York Times. 

    Tokyo 1995 sarin attack: Aum Shinrikyo cult trials end. (2011). BBC. Retrieved 06 Dec 2022, from https://www.bbc.com/news/world-asia-15815056 

    Tucker, J. B. (2006). War of Nerves: Chemical Warfare from World War I to Al-Qaeda. Pantheon Books. 

    WuDunn, S. (1995, 21 Jun 1995). Cultist Hijacks Japanese Jetliner, Demanding the Release of Leader. The New York Times. 

    WuDunn, S. (1997, 25 Apr 1997). Cult Guru Accused in Tokyo Subway Attack Pleads Not Guilty. The New York Times. 

    1 hr 30 min
  • Episode 32: Aum Shinrikyo Pt. 2 Armageddon Approaches

    The story of the doomsday cult continues, beginning with their first experiments with sarin and other chemical warfare agents in 1993.


    (1) Tucker, J. B. War of Nerves: Chemical Warfare from World War I to Al-Qaeda; Pantheon Books, 2006.

    (2) Medical Management of Chemical Casualties. Office, C. C. C., Ed.; U.S. Army Medical Research Institute of Chemical Defense: Aberdeen Proving Ground Maryland 21010, 1995.

    (3) Review of Acute Human-Toxicity Estimates for GB (Sarin). In Review of Acute Human-Toxicity Estimates for Selected Chemical-Warfare Agents; National Academies Press (US), 1997.

    (4) Kaplan, D. E.; Marshall, A. The Cult at the End of the World; Crown Publishers, Inc., 1996.

    (5) Sarin (GB): Nerve Agent. Centers for Disease Control and Prevention, 2011. https://www.cdc.gov/niosh/ershdb/emergencyresponsecard_29750001.html#:~:text=ANTIDOTE%3A%20Atropine%20and%20pralidoxime%20chloride,following%20exposure%20to%20be%20effective. (accessed 2022 10 Nov 2022).

    (6) Worek, F.; Thiermann, H.; Wille, T. Oximes in organophosphate poisoning: 60 years of hope and despair. Chemico-Biological Interactions 2016, 259, 93-98.

    (7) Peter, J. V.; Moran, J. L.; Graham, P. Oxime therapy and outcomes in human organophosphate poisoning: An evaluation using meta-analytic techniques. Crit Care Med 2006, 34 (2), 502-510.

    (8) Phosgene Health and Safety Guide; World Health Organization, inchem.org, 1998. https://inchem.org/documents/hsg/hsg/hsg106.htm#SectionNumber:3.1.

    (9) Phosgene. Agency, E. P., Ed.; epa.gov, 2000.

    (10) Borak, J.; Diller, W. F. Phosgene exposure: Mechanisms of injury and treatment strategies. J Occ Envior Med 2001, 43 (2), 110-119.

    (11) U.S. Army Activity in the U.S. Biological Warfare Programs. Army, Ed.; 1977; Vol. I.

    1 hr 6 min

About Lethal Dose

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A toxicology focused true crime podcast with Kayla Woods and Venus de Neko, covering all manner of crimes using drugs, toxins, and poisons from the common to the obscure.