Purely Clinical is more than an event; it’s an experience where education meets innovation and the future of skincare takes shape.

Over the past year, the Lira Clinical owners traveled across the globe delivering advanced education, protocol-driven learning, and exclusive first looks at upcoming innovations, straight to the treatment room. We’re recapping standout moments from the tour stops and unpacking what attendees truly gained, from interactive sessions and protocol development to testing prototypes and influencing product launches before they hit the market.

And of course, we’re teasing what’s ahead, because Purely Clinical 2026 is already shaping up to be something special. Join expert hosts and Lira Clinical founders Metaxia Dalikas and Francine Kagarakis for an inside look at the experience that’s redefining clinical education.

As we close the chapter of 2025 and reflect on all the things we accomplished, let's not forget the funny moments. Relive the laughs, bloopers, and real behind-the-scenes chaos that made 2025 unforgettable.

From breakthrough launches to meaningful milestones, this episode of A SkinDepth Convo reflects on a year that shaped the future of clinical aesthetics. Join us as we revisit our defining moments, celebrating innovation, education, and the community that made it all possible.

We look back on 2025, on a year of growth, innovation, and momentum, while setting intentions for what’s next.

Tune in for a thoughtful recap of 2025 and a celebration of how far we’ve come together.

In this episode of A SkinDepth Convo, hosts Metaxia Dalikas, Francine Kagarakis, and Anna Kagarakis dive into the beauty and complexity of treating diverse skin tones. Skincare is never one-size-fits-all, and understanding the needs of every background, heritage, and Fitzpatrick type is essential for truly inclusive care.

Joined by Licensed Esthetician Gerline Jean-Louis, owner of SYNRG and a renowned practitioner specializing in higher Fitzpatrick skin types, Gerline shares her passion for education and empowerment, and valuable insight into what makes deeper skin tones unique, the misconceptions that persist in the industry, and the most common challenges her clients face.

Together, they explore how to better support global beauty through informed practice and how Lira Clinical’s innovative, adaptable formulations help achieve bright, balanced, glowing results for every complexion.

Tune in for an inspiring, knowledge-packed conversation that celebrates diversity in skin health.

Things are getting spooky at A SkinDepth Convo! Hosts Anna Kagarakis, Metaxia Dalikas, and Francine Kagarakis are joined by the rest of the fabulous founders of Lira Clinical, Brenda Cumming, and Anna Konstantin, for a Halloween special you don’t want to miss.

From real-life treatment room scares to lessons learned the hard way, these skincare pros share chilling (and hilarious) stories that remind us why education, safety, and the right products are no trick; they’re the ultimate treat.

So grab your pumpkin spice latte, light that candle, and tune in… if you dare!

This October, in honor of Breast Cancer Awareness Month, we're sharing a deeply personal and inspiring story from Lira Clinical Co-Founder Metaxia Dalikas. As a breast cancer survivor, Metaxia opens up about her journey of courage, faith, and resilience, both in her personal battle and in her leadership of a global skincare company.

In this powerful episode, Metaxia discusses her diagnosis and treatment experience, the challenges of balancing her health while running a business, and the incredible support she received from her family and Lira Clinical co-owners. She also shares expert advice on caring for your skin before, during, and after cancer treatments.

Joining the conversation is fellow Lira Clinical founder and host Francine Kagarakis, who stood by Metaxia's side throughout her entire journey. Together, they offer hope, practical guidance, and inspiration for anyone facing similar challenges.

Join us for an exciting episode as we explore the beauty and skincare landscape down under! We're welcoming special guests from Lira Clinical's Australia and New Zealand distribution teams - Kristen Schultz and Jo-Ann Slecht - along with Lira Clinical founders Metaxia Dalikas and Francine Kagarakis, plus owner Brenda Cumming.

Discover the top skin conditions affecting the Oceania region and learn about the treatments and products making a real impact for clients. We'll also take you behind the scenes of the Global Skin Affair tour with exclusive highlights from the event.

As a bonus, our local experts will share insider travel tips and hidden gems you won't find in any guidebook. And yes, we'll even get the scoop on Vegemite and Kangaroo DNA!

On the new episode of A SkinDepth Convo, we're diving deep into our new favorite seasonal ingredient: Pumpkin!

When you think of pumpkin, your mind might go straight to lattes, pies, and fall decorations. But did you know it's also a powerhouse ingredient in skincare? Packed with vitamins and minerals, pumpkin brightens, hydrates, and repairs the skin, making it a true multitasking marvel. It's more than just a seasonal craze; it's a skincare game-changer.

Join our hosts Metaxia Dalikas, Francine Kagarakis, and Anna Kagarakis as they're joined by the Lira Clinical Education Team, Tiffany Fraedrich, George Gallegos, and Lu Ramos. Together, they get spicy discussing the new Pumpkin Plus Smart Peel™ from Lira Clinical and share fascinating facts about the pumpkin spice phenomenon, which has grown into an $800 million industry.

Listen now to uncover the powerful benefits of pumpkin and learn how a simple marketing idea from Starbucks in 2003 evolved into a global sensation.

In the latest episode of A SkinDepth Convo, hosts Metaxia, Francine, and Anna explore one of dermatology's most critical topics: skin cancer treatment through Mohs surgery.

Did you know success rates for Mohs Surgery are over 99% for basal cell carcinoma?

Joining us is Dr. Mariam Mafee MD, a board-certified dermatologist and Mohs surgeon at Rush University Medical Center (rush.edu) in Chicago. Known for her surgical expertise and compassionate patient care, Dr. Mariam Mafee discusses the intricacies of Mohs surgery, including post-surgery care, preparation for surgery, and why it is such a highly effective procedure in treating skin cancer. The discussion emphasizes the importance of patient education, the high success rates of Mohs surgery, and the need for awareness regarding skin health. Dr. Mafee also shares practical advice for patients, including the use of sunscreen, how long to wait to do a peel after surgery, and what other measures to take to protect your skin.

Whether you're a healthcare professional, someone facing a skin cancer diagnosis, or simply want to better protect your skin, this episode offers valuable insights that could save lives.

Get ready for an empowering discussion about women’s health, regenerative aesthetics, and building confidence from the inside out!

In this episode, hosts Metaxia Dalikas and Francine Kagarakis are joined by the incredible Dr. Chantal Lunderville, a physician trained at UCLA and UCSF and Lipgloss & Aftershave Medical + Wellness Editor, who’s redefining aging with a bold, holistic approach to esthetics and wellness. Hear from Dr. C, founder of her own esthetic practice and host of the podcast “Spilling the Medical Tea”, as she shares insights on the connection between skin, hormones, and overall health.

Plus, we’ll explore how spas are evolving into vital bridges between physicians and clients, and discuss the importance of combining traditional and holistic approaches to achieve true beauty and wellness.

Don’t miss this conversation packed with invaluable advice and expertise!