Biohacking Beauty: The Anti-Aging Skincare Podcast

There is an interesting contradiction in the way we talk about aging. We celebrate using technology to improve sleep, metabolism, cognition, recovery, and longevity, but when the same mindset is applied to appearance, the conversation can suddenly become much more judgmental.

In this episode of Biohacking Beauty, we sit down with Dave Asprey to explore that tension. We get into why he chose a facelift after major weight loss, whether cosmetic procedures belong in the biohacking conversation, and why wanting to look younger is often treated differently from wanting the rest of your body to function younger.

Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, CEO of Upgrade Labs, host of The Human Upgrade, and co-founder of Unlimited Life. We also talk about how he prepares his body before procedures, what he thinks people misunderstand about peptides, and his takes on GLP face, collagen supplements, Botox, stem cells, and the other tools people are using to change how they age.

What’s Discussed:

[13:02] Why Dave ultimately chose a facelift after major weight loss.

[15:24] Where non-surgical skin treatments reached their limit for the amount of excess skin he wanted to address.

[18:58] Why copying someone else’s longevity or supplement stack can backfire.

[28:59] Where to start when your biological-age markers look good but you still do not like what you see in the mirror.

[30:07] Why sleep, recovery, HRV, and other foundational markers still matter when thinking about aging.

[37:52] The stigma around cosmetic procedures in biohacking and why Dave questions where that line is drawn.

[44:56] Why he believes fear around aging and medical procedures can affect the body’s stress response.

[54:25] GLP-1s, muscle loss, and the changes people notice in facial appearance after weight loss.

Listen to this episode of Biohacking Beauty for a conversation about where “aging naturally” ends, where biohacking begins, and why that line becomes much more complicated when appearance enters the picture.

Find more from Young Goose:

Use code PODCAST10 to get 10% off your first purchase, and if you’re a returning customer use the code PODCAST5 to get 5% off atyounggoose.com

Instagram: @young_goose_skincare

Find more from Dave Asprey:

Website:daveasprey.com

LinkedIn: Asprey

Instagram:@dave.asprey

Facebook: Daveaspreyofficial

YouTube: DaveAspreyBPR

TikTok: @daveaspreyofficial

Book: “Heavily Meditated”: https://daveasprey.com/heavily-meditated/

Peptides are everywhere in skincare right now. They are in serums, moisturizers, lip products, cleansers, body washes, and even shampoos, all promising some version of smoother skin, more collagen, or fewer visible signs of aging.

But seeing “peptides” on a label tells you very little about whether the product can actually deliver those results. Which peptide is being used? Is there research behind that specific ingredient? Is there enough of it in the formula? Can it get through the skin barrier? And what happens when it is combined with everything else inside the bottle? So before you buy another peptide serum because the ingredient sounds impressive, it is worth knowing what actually makes a peptide useful for your skin and how formulation, delivery, concentration, and the rest of your routine can affect whether it works at all.

In this Biohacking Beauty Class, we are separating the science from the marketing around topical peptides. We get into which ones have more evidence behind them, what “Botox in a bottle” gets wrong, why some peptide products make more sense than others, and what to look for if your goal is supporting collagen, softening fine lines, and keeping your skin functioning well as it ages.

What’s Discussed:

(01:47) Do peptides actually belong in everything from serums to body wash?

(05:17) The biggest red flag when a skincare product uses peptides as the main selling point.

(08:26) What should actually back up an anti-aging peptide claim.

(11:11) Which topical peptides have more evidence behind them.

(13:01) Why neuropeptides are not really “Botox in a bottle.”

(15:54) What to know about using peptide products with vitamin C, retinoids, and other actives.

(17:46) Why pH, concentration, and the other ingredients in a formula can affect peptide stability.

(21:14) What actually makes a topical peptide product more likely to work.

(22:45) Why healthy skin function still matters when you are trying to support collagen and repair.

(25:09) If you could only add one peptide product to your routine, which type should it be?

Listen to this episode of Biohacking Beauty before another peptide claim on a skincare label convinces you to spend more without knowing what is actually inside the formula.

Previous Episodes Mentioned:

Nathalie Niddam: Peptides, Bioregulators, and the Truth About Skin Longevity

https://podcasts.apple.com/us/podcast/nathalie-niddam-peptides-bioregulators-and-the/id1552026927?i=1000736397042

Nathalie Niddam: The Potential of Peptides in Skin Health and Anti-Aging

https://podcasts.apple.com/au/podcast/nathalie-niddam-the-potential-of-peptides-in-skin/id1552026927?i=1000642759851

Peptides episodes to watch:

: https://www.youtube.com/watch?v=2AoqcXJ_MMc

Why Peptides Are Not the Shortcut Biohackers Think They Are with Chris Duffin: https://www.youtube.com/watch?v=UNPhDZXY6kw

Peptides, Hormones, and the Anti-Aging Protocol Most Women Start Too Late: https://www.youtube.com/watch?v=b_CTcFjeyqQ&t=428s

GHK-Cu Explained: The Copper Peptide That Signals Collagen Repair: https://www.youtube.com/watch?v=qGDNyVtZjl4

Find more from Young Goose:

Website: Use code PODCAST10 to get 10% OFF your first purchase, and if you’re a returning customer use the code PODCAST5 to get 5% OFF at younggoose.com

Instagram: @young_goose_skincare

You probably know which side of your face you prefer in photos. One jawline may look sharper. One cheek may sit differently. One under-eye may look darker. And while some facial asymmetry is completely normal, the way you use your mouth can also influence how the two sides of your face function over time.

In Part 2 of our conversation with Dr. Staci Whitman, we look at facial aging from inside the mouth. We get into how one-sided chewing, bite patterns, tongue function, palate width, airway health, and jaw structure can influence facial symmetry and the way changes become visible in the face. We also explore what adults can realistically do when the issue is structural rather than purely cosmetic. Dr. Staci breaks down the conversations happening around mastic gum, myofunctional therapy, palate expansion, MARPE, oral appliances, and tongue-tie releases, including why changing the way the mouth functions is much more complicated than trying the latest jawline trend online.

Dr. Staci Whitman is a board-certified pediatric dentist and Functional Medicine Certified Practitioner whose work focuses on functional dentistry, airway health, craniofacial development, the oral microbiome, and the mouth-body connection. She is the co-founder of the Institute for Functional Dentistry and founder of Bloom + Brighten.

What’s Discussed:

[1:37] Why persistent dark under-eyes may sometimes point to airway issues, inflammation, and facial structure rather than pigmentation alone.

[3:32] What happens to the jaw and the bones supporting the face as we age.

[6:44] How chewing predominantly on one side may contribute to differences between the two sides of the face.

[10:55] What your chewing patterns, saliva, and cavities may reveal about how you are using your mouth.

[17:09] Whether mastic gum and jaw exercises can actually change the appearance of an adult face.

[20:00] How tongue function, swallowing, and breathing are addressed through myofunctional therapy.

[21:50] Why a narrow palate may require more than simply changing your tongue position.

[22:30] What adults should know about palate expansion, MARPE, and oral appliances.

[31:26] Why finding a tongue tie does not automatically mean releasing it is the first step.

[40:49] Who to see when you suspect your bite, tongue, airway, or jaw function may be affecting your face.

Listen to this episode of Biohacking Beauty to learn why facial asymmetry may be giving you clues about what is happening inside your mouth.

Find more from Young Goose:

Website: www.younggoose.com/

Use code PODCAST10 to get 10% OFF your first purchase, and if you are a returning customer use code PODCAST5 to get 5% OFF.

Instagram: @young_goose_skincare

Find more from Dr. Staci Whitman:

Website: doctorstaci.com

Instagram: @doctor_staci

TikTok: @doctor_staci

YouTube: youtube.com/channel/

Book: SPIT: Why Your Mouth-and Its Microbes-Are the Secret to Whole-Body, Lifelong Health

Read Dr. Staci’s newsletter: substack.com/@doctorstaci

Find an oral-systemic health practitioner through AAOSH: aaosh.org/find-a-practitioner

Search the IAOMT directory for a biological dentist or health professional: iaomt.org/for-patients/Search/?ppage=dashboard

Find an airway-focused practitioner through AAPMD: aapmd.org/find-aapmd-professional

Search The Breathe Institute provider directory: breatheops.com/directory/the-breathe-institute

Learn more about the Institute for Functional Dentistry: functionaldentistry.org/

You can invest in your skincare, protect your collagen, and do everything you can to age well, while completely overlooking something that sits only a few inches away from your skin: your mouth. The way you breathe, chew, swallow, care for your gums, and support your oral microbiome can influence far more than your teeth.

In this episode of Biohacking Beauty, we sit down with Dr. Staci Whitman to explore how oral health connects to facial structure, airway health, under-eye darkness, inflammation, blood flow, and the appearance of your skin. We also get into the everyday oral habits that may be working against you, what actually matters in an oral routine, and the facial signs that can make Dr. Staci suspect something deeper is going on.

Dr. Staci Whitman is a board-certified pediatric dentist and Functional Medicine Certified Practitioner who specializes in the mouth-body connection, airway development, craniofacial growth, and the oral microbiome. She is the co-founder of the Institute for Functional Dentistry and founder of Bloom + Brighten, bringing functional medicine and systems biology into a part of health that is still often treated separately from the rest of the body.

What’s Discussed:

(01:17) Why humans chew dramatically less today and what that can mean for facial development.

(05:57) How mouth breathing, narrow airways, and modern eating habits can show up in the face.

(11:23) The oral bacteria involved in nitric oxide production and why blood flow matters for skin.

(13:02) Why saliva is one of the most overlooked parts of oral health and what happens when your mouth stays dry.

(16:50) Why Dr. Staci believes dentistry is missing a major piece of the longevity conversation.

(24:20) What actually matters in an oral-health routine, from meal timing and nasal breathing to flossing and microbiome testing.

(31:40) How hormones, pregnancy, perimenopause, and menopause can change oral health.

(40:52) What tongue scraping actually does and what your tongue may reveal about your health.

(46:02) What Dr. Staci notices about your face, eyes, lips, posture, and breathing before she even looks at your teeth.

Listen to this episode of Biohacking Beauty to learn why the way your face looks may be influenced by habits you have never considered part of your beauty routine.

Find more from Young Goose:

Website: www.younggoose.com/

Use code PODCAST10 to get 10% OFF your first purchase, and if you are a returning customer use code PODCAST5 to get 5% OFF.

Instagram: @young_goose_skincare

Find more from Dr. Staci Whitman:

Website: doctorstaci.com

Instagram: @doctor_staci

TikTok: @doctor_staci

YouTube: youtube.com/channel/

Book: SPIT: Why Your Mouth-and Its Microbes-Are the Secret to Whole-Body, Lifelong Health

Most of us assume that if something serious was happening inside our body, we would know. We would feel sick. Something would hurt. A blood test would catch it. But some health problems can develop quietly for years, and sometimes the clue that finally gets your attention is sitting right where you can see it: on your skin.

In this episode of Biohacking Beauty, we get into the skin changes that can point to something happening beyond the surface, from psoriasis and multiple skin tags to persistent rashes, hair loss, and subtle signs of skin cancer. We also talk about what makes a dermatologist look deeper, how long sun damage can build before it becomes visible, and when a skin concern deserves more than another product or treatment.

Dr. Mamina Turegano is a triple board-certified dermatologist, internist, and dermatopathologist, giving her a unique perspective that connects what is happening on the skin with what may be happening throughout the body. Her background in internal medicine and dermatopathology allows her to look beyond the appearance of a skin change and consider the metabolic, autoimmune, inflammatory, and systemic conditions that may be connected to it.

What’s Discussed:

(01:25) Why you can feel perfectly healthy while something is already changing internally.

(02:48) Why psoriasis can warrant looking at cardiovascular and metabolic health too.

(04:49) What multiple skin tags may tell you about insulin resistance.

(16:07) When an unexplained rash or chronic itching deserves a deeper workup.

(19:18) The skin cancer signs people may overlook and when hair loss needs more attention.

(23:14) How sugar, alcohol, stress, sleep, and circadian disruption can accelerate skin aging.

(35:31) Why Dr. Mamina is comfortable with topical peptides but not injectable peptides yet.

(45:24) Whether Google, AI skin scanners, and self-diagnosis are helping or hurting.

(48:53) How long sun damage may be building before you finally see it.

Listen to this episode of Biohacking Beauty to learn which skin changes are worth paying closer attention to, and why treating what you see is not always the end of the conversation.

Resources mentioned:

Want to find out more about Autophagy?

Listen here: The Overlooked Side of Autophagy Causing Aging - Part 1

The Overlooked Side of Autophagy Causing Aging - Part 2

Find more from Young Goose:

Website: younggoose.com

Use code PODCAST10 to get 10% OFF your first purchase, and if you’re a returning customer use code PODCAST5 to get 5% OFF.

Instagram: @young_goose_skincare

Find more from Dr. Mamina Turegano:

Website: DrMamina.com

Instagram: @dr.mamina

TikTok: @dr.mamina

YouTube: @dr.mamina

Social media has made skincare information easier to access than ever. One video can convince you to increase your retinol. Another influencer can tell you an ingredient is “toxic.” Then someone else swears your skin has stopped responding because you have used the same product for too long.

But think about what that can do to your skin when you follow every new rule without understanding what the product is actually doing. More stimulation is not always better. “Clean” does not automatically mean effective. A rosacea flare is not always something another soothing serum can fix. And moving to a stronger retinol just because your current one feels less intense may be the wrong move entirely.

In this Biohacking Beauty Class, we are answering the skincare questions our community keeps asking and unpacking the advice that sounds simple online but becomes much more complicated once you understand how skin actually responds. We also get into collagen supplements and share a few of the new Young Goose products and technologies we have been working on behind the scenes.

What’s Discussed:

(02:25) Can your skin actually get used to skincare products?

(07:44) Why “clean skincare” does not automatically mean better skincare.

(16:20) What may be driving rosacea when nothing seems to help.

(19:09) Why stronger retinol is not always the smarter next step.

(25:29) Do collagen supplements actually help your skin?

(30:10) The new cleanser and eye product coming to Young Goose.

(34:28) The new skincare technology we are testing in ampule form.

Listen to this episode of Biohacking Beauty before the next skincare tip on your feed convinces you to change something that may not need changing at all.

And before you go, we have a little listener bonus.

If you want to receive a product from us, leave us a review on Apple Podcasts. That is all you have to do.

If we read your review out loud on the podcast, we will send you a product in the mail. So leave us a review, make it cute, make it honest, and you might hear it in an upcoming Biohacking Beauty Class episode.

Find more from Young Goose:

Website: Use code PODCAST10 to get 10% OFF your first purchase, and if you’re a returning customer use the code PODCAST5 to get 5% OFF at younggoose.com

Instagram: @young_goose_skincare

When your skin starts changing in midlife, it is easy to assume the products that used to work suddenly stopped working. And when changing the routine does not fix it, hormones usually get the blame.

But there is another shift happening at the same time that rarely gets brought into the skin conversation: your gut. In this episode of Biohacking Beauty, we get into what starts changing in the gut through perimenopause and menopause, the surprising ways those changes can show up far beyond digestion, and why some of the health strategies women swear by before 40 may need to be reconsidered later.

Cynthia Thurlow is a nurse practitioner, host of the Everyday Wellness podcast, author of The Menopause Gut, and an international speaker with more than 25 years of experience in women’s health, metabolic health, perimenopause, menopause, and intermittent fasting.

What’s Discussed:

(04:01) The health crisis that changed the way Cynthia understood midlife health.

(19:12) The gut-hormone connection most women do not know exists.

(23:14) What changes when estrogen, immunity, and the gut start shifting together.

(29:13) The early signs that progesterone may be changing.

(35:49) What your gut may have to do with ovarian and mitochondrial aging.

(41:46) The part of longevity Cynthia thinks we are seriously underestimating.

(47:54) Why Cynthia changed her own approach to intermittent fasting after 40.

Listen to this episode of Biohacking Beauty to learn what midlife gut changes may have to do with your skin, and why the answer may go much deeper than changing your skincare routine.

Find more from Young Goose:

Website: Use code PODCAST10 to get 10% OFF your first purchase, and if you’re a returning customer use the code PODCAST5 to get 5% OFF at younggoose.com

Instagram: @young_goose_skincare

Find more from Cynthia Thurlow:

Twitter: @_CynthiaThurlow

Instagram: @cynthia_thurlow_

LinkedIn: cynthia-thurlow

YouTube: cynthiathurlow

Website: cynthiathurlow.com/

The Midlife Pause supplements: themidlifepause.com

Everyone wants skin that looks brighter, firmer, smoother, and healthier for longer.

But sometimes the thing holding your skin back is not the serum you forgot to buy. It is the blood sugar spike you keep missing, the protein you are not getting enough of, the sleep window you keep pushing, the strength training you keep delaying, or the daily stress your skin has to keep recovering from.

In this Biohacking Beauty Class episode, we are talking about the habits we actually use to support skin health outside of skincare. We get into the choices that help your skin repair better, age slower, respond better to treatments, and build the kind of foundation no product can fully replace.

What’s Discussed:

(03:10) The dessert rule that helps reduce daily sugar exposure.

(05:37) Why fiber matters beyond digestion.

(06:26) What a glucose monitor can show you about foods that look “healthy.”

(08:04) Why lifting weights can change how your skin looks over time.

(10:13) What protein and micronutrients have to do with collagen support.

(11:24) How morning sunlight, sleep, and circadian rhythm connect to skin repair.

(16:16) Where red light therapy, antioxidants, and consistency fit into the bigger skin longevity picture.

Listen to this episode of Biohacking Beauty to learn the habits we swear by when we want our skin to have more to work with than skincare alone.

And before you go, we have a little listener bonus.

If you want to receive a product on us, leave us a review on Apple Podcasts. That is all you have to do.

If we read your review out loud on the podcast, we will send you a product in the mail. So leave us a review, make it cute, make it honest, and you might hear it in an upcoming Biohacking Beauty Class episode.

Find more from Young Goose:

Website: Use code PODCAST10 to get 10% OFF your first purchase, and if you’re a returning customer use the code PODCAST5 to get 5% OFF at younggoose.com

Instagram: @young_goose_skincare

Thyroid dysfunction is often treated like it is easy to rule out. You ask for labs, your doctor checks TSH, and if that one marker is not flagged, you are told your thyroid is fine.

But what if that is the problem?

In this episode of Biohacking Beauty, we sit down with Dr. Amie Hornaman to unpack what most thyroid conversations skip: the difference between being “normal” on paper and having enough active thyroid hormone available to your cells. She explains why TSH is not a thyroid hormone, why T4-only medication may not be enough for many people, and why women can keep struggling even after being told their thyroid is not the issue.

Dr. Amie is known as The Thyroid Fixer, a functional medicine doctor, host of The Thyroid (and Hormone) Fixer podcast, founder of the Advanced Thyroid and Hormone Clinic, and author of The Thyroid Fix. After being misdiagnosed by six different doctors, she built her practice around helping patients get the answers conventional medicine often misses.

What’s Discussed:

(01:22) Why so many women feel like their body is rebelling against them.

(04:32) Why the diagnosed hypothyroidism number may not reflect the real problem.

(07:11) The difference between being undiagnosed, undertreated, and mistreated.

(10:54) Why skin aging after 40 is not only an estrogen conversation.

(14:22) How quickly thyroid and hormone changes can show up in the skin.

(20:57) Why skin aging needs an inside-out and outside-in approach.

(28:35) What markers belong on a full thyroid panel beyond TSH.

(30:55) Why free T3, reverse T3, and thyroid antibodies matter.

(38:48) What thyropause is and why it can overlap with perimenopause and menopause.

(45:01) A one-morning plan to support thyroid, insulin, protein, sleep, and skin health.

Listen to this episode of Biohacking Beauty to understand why your thyroid labs may not be telling the whole story, and why your skin, hair, metabolism, mood, and energy may be showing what one marker missed.

Find more from Young Goose:

Use code PODCAST10 to get 10% OFF your first purchase, and if you’re a returning customer use the code PODCAST5 to get 5% OFF at younggoose.com

Instagram: @young_goose_skincare

Find more from Dr. Amie Hornaman:

Website: dramie.com

Instagram: @dramiehornaman

Podcast: dramie.com/podcast/

Exosomes have become one of the most talked-about ingredients in advanced skincare, but the conversation around them can get confusing fast. Some people hear “cellular messaging” and worry about DNA. Others see plant exosomes, stem cell claims, growth factors, or vampire facial comparisons and assume all exosome products are working the same way.

The problem is that the word “exosome” does not tell you enough. Exosomes are messengers, and the message depends on the source. A plant-derived exosome, a mesenchymal-derived exosome, and a platelet-derived exosome are not carrying the same type of signal for the skin. So before you trust the trend, it helps to understand what kind of message your skin is actually receiving.

In this Biohacking Beauty Q&A, we break down the biggest questions listeners have been asking about exosomes. We get into why exosomes do not change your DNA, what microRNA messaging means, why consistency matters, how plant exosomes compare to human-derived options, why platelet-derived exosomes may be especially relevant for skin repair, and what makes Vampire Exosomes® different from other exosome serums.

What’s Discussed:

03:05 Whether exosomes can change your DNA or transfer genetic material.

07:08 How exosomes work through microRNA messaging instead of changing your genome.

09:21 Why exosome messages do not stick around forever and need consistency.

11:02 Where exosomes come from and why the source of the message matters.

13:45 Why plant exosomes may offer some benefits, but may not be the strongest fit for skin repair.

21:34 How mesenchymal-derived and platelet-derived exosomes differ in their relationship to skin repair.

27:29 What makes Vampire Exosomes® different from other exosome serums, including dose, NAD support, barrier support, and batch verification.

32:25 How Vampire Exosomes® compares to a vampire facial and why topical exosomes work differently.

Listen to this episode of Biohacking Beauty to understand what exosomes actually are, what questions to ask before buying an exosome product, and why the source, dose, formula, and proof matter as much as the word “exosome” itself.

Find more from Young Goose:

Use code PODCAST10 to get 10% OFF your first purchase, and if you’re a returning customer use the code PODCAST5 to get 5% OFF at younggoose.com

Young Goose Vampire Exosomes® https://www.younggoose.com/products/vampire-exosomes

Instagram: @young_goose_skincare