For years, skincare has focused on surface-level solutions, moisturizers, retinol, collagen creams… but what if we told you that true skin rejuvenation starts at the cellular level? Traditional skincare is designed to mask aging, but new research in longevity science reveals that the root causes of aging go much deeper.

In this episode of Biohacking Beauty, I break down the real drivers of skin aging, from mitochondrial dysfunction and NAD decline to epigenetic shifts, senescent cells, and impaired autophagy. I also discuss why most anti-aging products don’t actually reverse aging, and how cutting-edge biohacking ingredients like NAD+, spermidine, copper peptides, and advanced vitamin C are changing the game.

This is the future of skincare, moving beyond temporary fixes and truly reprogramming skin cells for longevity. 

If you’ve ever wondered why your skin isn’t responding to traditional skincare, or how you can actually slow down and even reverse the aging process, this episode is for you!

I Also Discuss:

(00:01) The Science of Ageless Skin

(04:54) Your Mitochondria Are Aging Your Face

(12:21) Can You Actually Reverse Skin Aging?

(17:21) The Truth About Skincare Lies

Learn More About

Young Goose

• Use code PODCAST10 to get 10% off your first purchase, and if you’re a returning customer use the code PODCAST5 to get 5% off at https://www.younggoose.com/ 
• Instagram: @young_goose_skincare

Welcome back to Biohacking Beauty! Today, we’re diving into the cutting-edge science of biological vs. chronological aging and how epigenetic testing is revolutionizing the way we understand skin longevity. Aging isn’t just about the number of birthdays you’ve had—it’s about how your cells are aging at the molecular level. And now, thanks to advancements in epigenetics and AI-driven diagnostics, we can measure and even influence that process.

In this episode, I sit down with Hannah Went, an expert in biological age testing and the Director of Operations at TruDiagnostic, a leading epigenetics company. We explore how biological aging manifests in the skin, why epigenetic markers are more predictive of health than genetics, and how personalized interventions can actually slow or even reverse aging at the cellular level.

Hannah also shares groundbreaking research on how lifestyle choices, like diet, sleep, and even skincare, can alter gene expression and influence the rate at which we age. Plus, we discuss how advanced testing methods can provide real-time feedback on how well anti-aging interventions are actually working. If you’ve ever wanted to take a data-driven approach to longevity, this episode is packed with insights you won’t want to miss.

Hannah Went is the Director of Operations at TruDiagnostic, a company at the forefront of biological age testing and longevity research. With a background in epigenetics and functional medicine, she’s dedicated to helping individuals track and optimize their health using cutting-edge diagnostic tools.

We Also Discuss:

(00:01) Epigenetics and Biological Age Testing

(13:47) Aging and Skin Link Exploration

(26:13) Genetic Influence on Phenotype and Aging

(31:37) Aging, Skin Health, and Lifestyle Factors

(44:43) At-Home Genetic Testing Support

Learn more about:

Young Goose

• Use code PODCAST10 to get 10% off your first purchase, and if you’re a returning customer use the code PODCAST5 to get 5% off at https://www.younggoose.com/ 
• Instagram: @young_goose_skincare

Hannah Went

• Website: everythingepigenetics.com 
• Instagram: @everythingepigenetics

Have you ever wondered why traditional sunscreens aren’t enough to protect your skin from all forms of light damage? In this episode of Biohacking Beauty, I’m sitting down with Jamie McGuire to break down the truth about blue light exposure, SPF, and effective melasma protocols.

We dive into why hyperpigmentation often worsens with artificial light exposure, the importance of full-spectrum protection, and how Young Goose’s innovative formulas address common skin concerns like melasma, sensitivity, and inflammation. Plus, we tackle the "clean beauty" debate—are some ingredients being unfairly criticized?

Jamie McGuire is a skincare expert with over 15 years of experience in personalized skincare protocols. Her holistic approach focuses on helping clients achieve long-term skin health through science-backed recommendations and innovative biohacking products.

Whether you’re dealing with melasma or looking for smarter protection against blue light, this episode offers valuable insights and real solutions to refine your routine for radiant, resilient skin.

We Also Discuss:

46:04 - 49:10 – The Reality of "Clean Beauty": Understanding Controversial Ingredients

49:11 - 50:39 – Melasma and Hyperpigmentation: Understanding the Triggers

50:40 - 54:30 – Melasma Protocol Breakdown: Step-by-Step Routine

54:31 - 57:07 – The Power of BioShield SPF 40: Protection Beyond UV Rays

57:08 - 01:00:13 – Why Retinol Sensitivity Happens (and How Bioretinol Prevents It)

01:00:14 - 01:02:23 – Red Light Therapy Synergy with Green Tea Phyto Serum

Learn More About

Jamie McGuire

• Instagram: @jamieanneaesthetics
• Website: www.jamieanne.co/

Young Goose

• Use code PODCAST10 to get 10% off your first purchase, and if you’re a returning customer use the code PODCAST5 to get 5% off at https://www.younggoose.com/ 
• Instagram: @young_goose_skincare

Most people don’t think about their skin until they have to. The reality is, by the time we notice fine lines, dullness, or inflammation, deeper processes have already been at play for years. But what if your skin isn’t just reflecting aging? What if it’s reflecting your overall health, stress levels, and even brain function?

In this episode of Biohacking Beauty, I sit down with Dr. Scott Sherr to uncover the fascinating connection between your skin and brain, a relationship most people don’t even realize exists. This conversation originally took place on The Smarter Not Harder Podcast, where Scott and I explored the skin-brain axis and how your skin is more than just a barrier, it’s an active communicator with your nervous system, influencing everything from inflammation to stress resilience and even cognitive function.

We also tackle some of the biggest misconceptions in skincare, like why hydration doesn’t actually come from the outside, how sun exposure impacts your skin at a cellular level, and the surprising ways senescent cells in your skin accelerate whole-body aging. Plus, we break down the latest science on hormones, collagen production, and microbiome health, and how all of these factors impact how your skin ages.

Dr. Scott Sherr is the host of the Smarter Not Harder Podcast and a physician specializing in health optimization, hyperbaric therapy, and longevity medicine. As the founder of Integrative HBOT and a leading expert in performance medicine, he helps individuals leverage cutting-edge science to enhance vitality, slow aging, and optimize brain and body function.

If you want to know how to extend your skin’s youthfulness beyond just skincare products, this is an episode you won’t want to miss!

We Also Discuss:

(00:00) Skin-Brain Axis

(12:43) Skin Aging and Evolution

(27:15) Skin Microbiome and Postbiotics

(35:39) Hormones, Skin Aging, and Repair

(49:16) Living Smarter, Not Harder

(56:07) Sunscreen and Skin Protection

(01:01:36) Vitamin C and Spermidine in Skincare

(01:10:16) Skin Health and Spermidine Benefits

(01:16:43) Biohacking Beauty Podcast and Skincare

Learn more about:

Young Goose

• Use code PODCAST10 to get 10% off your first purchase, and if you’re a returning customer use the code PODCAST5 to get 5% off at https://www.younggoose.com/ 
• Instagram: @young_goose_skincare

Scott Sherr

• Website: https://home-sf.co/ 
• Instagram: https://www.instagram.com/drscottsherr/ 
• Youtube: Smarter not Harder Podcast

Have you ever wondered why some skincare products seem to work wonders for some people, while others see little to no results? In this episode of Biohacking Beauty, I’m sitting down with Jamie McGuire, a skincare consultant with over 15 years of experience, to break down the truth behind personalized skincare and why a one-size-fits-all approach just doesn’t cut it.

We dive into the difference between traditional retinol and bioretinol, the science of vitamin A delivery systems, and how the right formulations can repair your skin without triggering irritation. Plus, we tackle the “clean beauty” debate—are some ingredients unfairly villainized? We share tips on balancing safe skincare choices with products that actually move the needle for your long-term skin health.

Jamie McGuire is a seasoned skincare expert and founder of a wellness platform that prioritizes personalized regimens and holistic approaches to beauty. Her mission is to help clients navigate an overwhelming skincare landscape with science-backed recommendations that support radiant, resilient skin.

Whether you’re a skincare minimalist or a product enthusiast, this episode will give you the tools to refine your routine and reach your goals.

We Also Discuss:

24:00 - 28:25- Why Bioretinol Stands Out: Gentle Yet Powerful Skin Renewal

28:26 - 31:27 - How Bioretinol Mimics Your Body’s Natural Vitamin A Process

31:28 - 35:52 - The Debate on Clean Beauty: Are ‘Toxins’ in Skincare Really Harmful?

35:53 - 41:20 - Breaking Down Ingredients: What You Should Really Avoid

41:21 - 46:03 - Pick Your Poison: Finding Balance in Your Skincare Choices

Learn More About 

Jamie McGuire

• Instagram: @jamieanneaesthetics
• Website: www.jamieanne.co/

Young Goose

• Use code PODCAST10 to get 10% off your first purchase, and if you’re a returning customer use the code PODCAST5 to get 5% off at https://www.younggoose.com/ 
• Instagram: @young_goose_skincare

Many of us think of plastic surgery as a drastic, last-resort solution, but what if the secret to natural, long-lasting results isn’t about doing more, but doing less? The field of facial rejuvenation has evolved dramatically, moving away from overly invasive procedures and toward minimally invasive, high-impact techniques that enhance both appearance and skin health.

In this episode of Biohacking Beauty, I sit down with Dr. Cameron Chesnut, a pioneer in holistic plastic surgery, to discuss how strategic, small interventions can create incredible, natural-looking results. Dr. Chesnut explains why traditional plastic surgery approaches are outdated, how perception drift is distorting beauty standards, and the biggest mistakes people make with fillers and cosmetic procedures.

This is a conversation I’ve been wanting to have for a long time because there’s so much misinformation around cosmetic treatments, skin aging, and longevity. We also dive into cutting-edge recovery techniques, including peptides, hyperbaric oxygen therapy, and regenerative medicine, and how these tools are revolutionizing post-surgical healing and long-term results.

Dr. Cameron Chesnut is a board-certified dermatologist and facial cosmetic surgeon known for his minimally invasive, high-tech approach to plastic surgery. With a background in biohacking, regenerative medicine, and longevity science, he helps patients achieve natural, long-lasting results while prioritizing overall health and well-being.

We Also Discuss:

(00:02) Innovations in Biohacking Plastic Surgery

(09:47) Strategies for Longevity and Anti-Aging

(18:02) Biostimulatory Fillers' Impacts on Facial Symmetry

(24:05) Pre-Surgical Peptides and Recovery Optimization

(31:09) Regenerative Medicine for Enhanced Recovery

(40:32) Future Trends in Plastic Surgery

(46:53) Future of Minimally Invasive Plastic Surgery

(53:00) Holistic Health Strategies for Youthfulness

(01:06:18) Specialties in Facial Plastic Surgery

Learn more about Young Goose:

Use code PODCAST10 to get 10% off your first purchase, and if you’re a returning customer use the code PODCAST5 to get 5% off at https://www.younggoose.com/ 

Instagram: @young_goose_skincare

Learn more about Dr. Cameron Chesnut:

Instagram: https://www.instagram.com/chesnut.md/ 

Website: https://www.clinic5c.com/ 

Resources:

Spermidine research: https://www.longevitybioresearch.org/

Spermidine in health and disease: https://www.science.org/doi/10.1126/science.aan2788

Have you ever stopped to think about the invisible forces that are silently aging your skin—and how the right tools can reverse the damage? In this episode of Biohacking Beauty, I’m diving into a fascinating conversation with Jamie McGuire, a skincare expert and passionate advocate for long-term skin health.

We explored the often-overlooked role of the skin barrier in maintaining youthful, healthy skin and why NAD, the molecule of cellular repair, is a game-changer. From breaking down what “leaky skin” really means to revealing how inflammation and environmental stressors disrupt your skin’s ability to heal, this episode is packed with essential insights for anyone serious about biohacking their skincare.

Jamie McGuire is a leading skincare consultant and founder of a wellness platform specializing in customized regimens and holistic health. With over 15 years of experience, she helps clients achieve radiant skin through science-backed solutions. Her expertise and educational approach make her a trusted voice in skincare.

We Also Discuss: 

00:00 - 07:45 - The Science of NAD: Unlocking Skin Repair and Resilience

07:45 - 16:20 - Leaky Skin Explained: Repairing Your Barrier for Lasting Results

16:20 - 23:57 - How Inflammation Sabotages Your Skin—and How to Stop It

Learn More About

Young Goose

• Use code PODCAST10 to get 10% off your first purchase, and if you’re a returning customer use the code PODCAST5 to get 5% off at https://www.younggoose.com/ 
• Instagram: @young_goose_skincare
• 
  

Learn More About 

Jamie McGuire

• Website: https://www.jamieanneaesthetics.com/skincare 
• Instagram: https://www.instagram.com/jamieanneaesthetics/

Many of us chase radiant, youthful skin by investing in expensive products, but I’ve learned that the secret to lasting results often lies beneath the surface—literally. Your gut health plays a pivotal role in your skin’s appearance, influencing everything from hydration to inflammation and even premature aging. The more I dive into this topic, the more I realize how understanding the gut-skin connection is key to unlocking healthier, glowing skin.

In this episode of Biohacking Beauty, I sit down with Melissa Boloña, founder of The Beauty and the Broth, to discuss how gut health impacts our skin and why bone broth has become a cornerstone of so many wellness routines. Melissa shares her personal journey of overcoming chronic digestive issues and autoimmunity, and we break down the science behind bone broth’s bioavailability, its role in repairing the gut lining, and how it supports collagen production while reducing inflammation.

This is a conversation I’ve been wanting to have for a long time because the connection between gut health and skin health is often overlooked. We also dive into common misconceptions about collagen supplements, why sourcing and bioavailability matter, and how simple changes to your routine can have a profound impact on your overall health and appearance.

Melissa Boloña

is the founder of The Beauty and the Broth, a wellness brand redefining bone broth with convenience and quality. After overcoming chronic digestive issues and autoimmunity, she became passionate about the gut-skin connection and ancestral nutrition. 

Let's dive in!

We Also Discuss:

(00:01) The Power of Bone Broth

(08:50) Discovering the Benefits of Bone Broth

(20:30) Exploring Bone Broth Sourcing and Benefits

(29:57) Exploring Nutrition & Lifestyle Choices

(35:15) Balancing Business and Wellness Priorities

(50:22) Navigating Brand Integrity and Decision-Making

Learn more about:

Young Goose

• Use code PODCAST10 to get 10% off your first purchase, and if you’re a returning customer use the code PODCAST5 to get 5% off at https://www.younggoose.com/ 
• Instagram: @young_goose_skincare

Melissa Boloña

• Website: https://thebeautyandthebroth.com
• Instagram: https://www.instagram.com/melissabolona

We all want to live longer, healthier lives—but what if the key to longevity isn’t just about doing more, but understanding how your body adapts to stress? From navigating everyday challenges to the science of hormesis, the small, intentional stressors we introduce can either build resilience or break us down.

In this episode of Biohacking Beauty, I sit down with Dr. Nasha Winters, a pioneer in metabolic oncology and someone I’ve admired for years, to unpack the real story behind resilience and how it ties into beauty, health, and longevity. We dive into how your body’s response to stress—whether it’s from your environment, your relationships, or even your skincare routine—can impact everything from mitochondrial health to cellular repair.

We also get real about why your sense of purpose isn’t just motivational fluff—it’s a biological powerhouse that can extend your life. Plus, we discuss how building community and avoiding isolation might just be the ultimate biohack.

Dr. Nasha Winters has over 30 years of experience in metabolic health and mitochondrial optimization. Her work isn’t just about preventing disease—it’s about living with purpose, vitality, and strength.

This conversation will open your eyes to how the small, everyday choices you make can completely shift your health trajectory. Let’s dive in!

We Also Discuss:

(00:01) Biohacking and Integrative Medicine Discussion

(12:49) Harnessing Hormesis for Health and Wellness

(26:54) Mindful Practices and Stress Response

(37:37) Navigating Health and Wellness Journey

(51:05) Embracing Evolution and Purpose in Wellness

(01:08:00) Gratitude and Excitement for Reunion

Learn more about:

Young Goose

• Use code PODCAST10 to get 10% off your first purchase, and if you’re a returning customer use the code PODCAST5 to get 5% off at https://www.younggoose.com/ 
• Instagram: @young_goose_skincare

Dr. Nasha Winters

• Website: https://www.drnasha.com/ 
• Instagram: https://www.instagram.com/drnashawinters/

Most of us have heard of exfoliation, and you may already be incorporating this step into your routine. But did you know that exfoliation plays a pivotal role in keeping your skin radiant and healthy? Think of exfoliation as prepping a canvas before painting. Just like you wouldn't apply fresh paint on a wall without preparing it first, you shouldn't apply skincare products on a layer of dead skin cells. 

Welcome to another episode of the Biohacking Beauty podcast brought to you by Young Goose Skincare! In this episode, host Amitay Eshel, the CEO of Young Goose, dives into an essential step in your skincare routine: exfoliation. He covers why exfoliation is crucial for maintaining healthy skin, and the difference between chemical and mechanical exfoliation. Plus, he shares the importance of understanding the needs of your skin.

What we discuss:

[00:02:25] Why skin cell turnover is crucial for maintaining healthy skin 

[00:03:15] Chemical vs. mechanical exfoliation

[00:04:08] The benefits of proper exfoliation

[00:08:22] Why understanding the needs of your skin is essential

Key Takeaways:

• Exfoliation plays an important role in enhancing the absorption and effectiveness of skincare products. By removing the layer of dead skin cells on the surface of your skin, exfoliation allows the active ingredients in skincare products to penetrate more deeply and work more effectively. This means that your moisturizers, serums, and treatments can better target and address specific skin concerns, resulting in improved overall skincare results.
• There are two primary types of exfoliation: mechanical and chemical. Mechanical or physical exfoliation entails physically scrubbing the skin using an abrasive substance. In contrast, chemical exfoliation involves using ingredients such as acids or enzymes that dissolve the glue binding the dead skin cells together.
• Understanding the specific requirements of your skin is vital for effective exfoliation. Oily skin, for instance, often faces issues like excessive dead skin cells and clogged pores. Frequent exfoliation can be beneficial in maintaining a clearer complexion for oily skin types. On the other hand, dry skin may require a gentler approach to exfoliation, as it tends to be more sensitive.

Learn More about Young Goose:

• Use code PODCAST10 to get 10% off your first purchase, and if you’re a returning customer use the code PODCAST5 to get 5% off at https://www.younggoose.com/ 
• Instagram: @young_goose_skincare