Every fibroblast inside your dermis right now is asking 200 to 2,000 mitochondria to power its work in real time, and those mitochondria are descendants of a free-living bacterium swallowed by a larger cell 2 billion years ago. As you age, those mitochondria run slower and your cells build fewer of them to replace the ones that fail.

In this solo episode, Young Goose co-founder Amitay Eshel breaks down the two sides of mitochondrial decline that drive skin aging and explains why the science-led skincare category has spent the last decades addressing only one of them.

The first side of skin aging is where most skincare brands have built their products around. The other side is the one almost no skincare on the market is formulating for, and it is where the next chapter of skin longevity is being written.

If you have outgrown the antioxidant-and-peptide era of skincare and want to understand what is actually happening underneath your skin as it ages, this episode is for you.

What's Discussed:

(01:35) The 2-billion-year-old contract inside every skin cell that is now fraying.

(04:10) Why skin is one of the most mitochondria-dense organs in your body.

(08:20) The 2012 paper that showed NAD drops by half between 35 and 70.

(13:15) How a refugee fired in 1933 figured out the chemistry your cream still runs on.

(16:30) The second half of the decline almost no skincare addresses.

(19:45) The master regulator that decides whether your cells can hire.

(24:00) The two columns of mitochondrial biology and why most brands only work in one.

(32:10) Why this is a ten-year strategy, not a two-week one.

Resources Mentioned:

Download the Cellular Energy Protocol: https://www.younggoose.com/pages/the-mitochondrial-skin-stack

Age-Associated Changes in Oxidative Stress and NAD+ Study: journals.plos.org/plosone/article/

FASEB study on how methylene blue delays cellular senescence cells: faseb.onlinelibrary.wiley.com/doi/

Find more from Young Goose:

Use code PODCAST10 to get 10% OFF your first purchase, and if you’re a returning customer use the code PODCAST5 to get 5% OFF at younggoose.com

Instagram: @young_goose_skincare

Roughly 25% to 30% of the population carries slow variants in the MAOA or COMT genes, the two enzymes responsible for clearing adrenaline, dopamine, and serotonin from the brain.

For these individuals, common polyphenols marketed for inflammation and longevity, including curcumin, act as weak MAOA inhibitors that further slow neurotransmitter breakdown. The result is a quiet buildup of stimulation that gets misread as anxiety, insomnia, or unexplained agitation, with no obvious connection to the supplement bottle that caused it.

In this episode of Biohacking Beauty, Dr. Tyler Panzner joins us to translate exactly this kind of pharmacological nuance into protocols people can actually use. He is a PhD pharmacologist with research in neuropharmacology and breast cancer metastasis, and has worked with over 900 clients, particularly highly sensitive people, to identify their genetic weak points and remove the supplements quietly working against them.

If you are stacking longevity supplements, feel wired without explanation, or want to understand why your body responds differently than the marketing promises, this episode is for you.

What's Discussed:

03:15 Why supplements are the "Wild West" of holistic health.

08:42 The hidden problem with curcumin, resveratrol, and EGCG for sensitive people.

15:30 The four gas pedals of the brain: adrenaline, histamine, glutamate, and sulfur.

22:18 Stress vs. anxiety and how the brain builds narratives around physiological activation.

29:45 Why your meditation practice may be failing because of a supplement.

37:20 NMN degradation, the NAMPT "toll booth," and topical vs. systemic delivery.

46:08 The future of multi-omics testing and personalized protocols.

Find more from Young Goose:

Use code PODCAST10 to get 10% off your first purchase, and if you’re a returning customer use the code PODCAST5 to get 5% off at younggoose.com

Instagram: @young_goose_skincare

Find more from Dr. Tyler Panzner:

Website: drtylerpanzner.com

Instagram: @drtylerpanzner

Facebook: Dr. Tyler Panzner

Linkedin: Tyler Panzner, Ph.D.

YouTube: @drtylerpanzner

FREE Guides: drtylerpanzner.com/free-guides

1:1 Genetic Coaching: https://drtylerpanzner.com/startyourjourney

Quieting an Overactive Mind Webinar: https://overstimulated.drtylerpanzner.com/webinar-registration-page

Your skin has a biological age and for most people, it's not the same as their chronological one. Mayo Clinic published the SkinSpan framework this year specifically to quantify it, and the 12 Hallmarks of Aging now have a direct application to dermal tissue.

This raises an uncomfortable question: if you're already optimizing everything below the neck with NAD IVs, peptides, and red light, why is the skincare on your face still operating on a paradigm from 1987?

In this new episode of the Biohacking Beauty Podcast, we give you a preview of the keynote we're delivering at Dave Asprey's Beyond Conference and walk you through the 3-pillar framework that replaces traditional anti-aging skincare with longevity science in mind.

Because the results you can feel today and results you can measure in ten years are not the same thing. And we think you deserve both.

Let's dive in.

What's Discussed:

(2:29) The gap no one in longevity talks about.

(3:06) Why your moisturizer is 38 years behind your supplements.

(6:21) The 12 Hallmarks of Aging, decoded.

(9:42) Pillar 1: The master pathway of skin aging.

(12:18) Why NAD in a jar doesn't work (and what does).

(14:22) The cellular housekeeping system that quietly shuts down with age.

(15:17) The peptide that affects 32% of your skin's genome.

(16:55) Pillar 2: The software updates your cells stop sending.

(20:09) The PRP lineage that changed regenerative aesthetics.

(22:54) Pillar 3: The pillar our community doesn't want to hear about.

(29:09) The protocol, tiered by where you're starting.

(37:55) How Young Goose fits into what you're already doing.

(40:32) The two tests we're building to measure skin longevity.

Find more from Young Goose:

• Use code PODCAST10 to get 10% off your first purchase, and if you’re a returning customer use the code PODCAST5 to get 5% off at https://younggoose.com
• Instagram: @young_goose_skincare
• Head to younggoose.com/products/youth-body-cream for 20% off

The melanocytes giving pigment to your skin right now might be older than your car. They have been sitting in your dermis for decades, and unlike the cells on your skin's surface, they do not get replaced. They have to keep themselves clean which happens through autophagy.

In Part 2 of our autophagy deep dive, we get specific about how skin handles autophagy differently from other parts of the body. We unpack why long-lived cells like fibroblasts and melanocytes depend on this cleanup process, what happens when it fails, and how it ties directly to gray hair, hyperpigmentation, sagging skin, and that brownish dullness no serum seems to fix.

We also introduce one of the most overlooked players in this entire conversation, and explain why we believe it is the next NAD. If you want to understand what is actually happening underneath your skin as it ages, and what tools we have to intervene at the cellular level, this episode is for you.

What's Discussed:

• (01:06) Why skin needs autophagy more than almost any other organ
• (03:07) The cells on your face that may be older than your car
• (04:25) The 2013 paper that linked autophagy failure to dermatitis
• (08:44) Zombie mitochondria and why photo-aged skin makes bad collagen
• (12:25) Senescent cells, SASP, and how a few bad cells poison the dermis
• (18:38) The 2019 Drexel rapamycin trial that proved this works in humans
• (23:22) The 2024 spermidine study that changes how we think about autophagy
• (29:51) Why your skin barrier collapses without this one molecule

Resources Mentioned:

Biohacking Beauty Podcast with Dr. Scott Sherr: Stress & Light on Your Skin Are Aging Your Entire Body Podcast/dr-scott-sherr-stress-light-on-your-skin-are-aging/

2024 Study on endogenous spermidine as essential for rapamycin-induced autophagy and longevity: pubmed.ncbi.nlm.nih.gov/39212197/

Young Goose Companion Booklet: younggoose.com/pages/autophagy-skin-activate-your-bodys-anti-aging-system

Find more from Young Goose:

• Use code PODCAST10 to get 10% OFF your first purchase, and if you’re a returning customer use the code PODCAST5 to get 5% OFF at younggoose.com
• Instagram: @young_goose_skincare

What if your skin could literally rebuild itself from the inside out? In this episode, we break down one of the most powerful and misunderstood biological processes in the human body: autophagy.

From its Nobel Prize-winning discovery to the molecular machinery that drives it, we walk you through exactly what autophagy is, how it works at the cellular level, and why it matters far more than most people realize for skin aging.

We explore the two master switches that control autophagy, mTOR and AMPK, and how the constant tug of war between them determines whether your cells are in build mode or cleanup mode. We also explain why most people in the modern world are stuck in permanent mTOR activation, and what that means for how their skin ages over time.

This is Part 1 of our deep dive. In Part 2, we go skin-specific and break down exactly how autophagy renews your skin at the tissue level.

What's Discussed:

(0:19) The "phoenix process": the cellular mechanism rebuilding your skin from the inside out

(3:14) What autophagy actually means, and why the science world ignored it for 30 years

(4:47) How baker's yeast cracked the code that won the 2016 Nobel Prize

(7:14) Inside a single skin cell: the step-by-step breakdown of how autophagy actually works

(10:22) Why autophagy is not destruction, and what this means for your collagen supplements

(16:44) The two master switches controlling whether your cells build or clean

(20:10) The everyday habit silencing your body's most powerful anti-aging system

(26:17) Why aging skin isn't broken, it has just never been told to clean

Resources Mentioned:

Biohacking Beauty Podcast: Ben Azadi: Why 93% of Americans Are Aging Too Fast + What to Do About It: podcasts.apple.com/us/podcast/ben-azadi

Find more from Young Goose:

Use code PODCAST10 to get 10% OFF your first purchase, and if you’re a returning customer use the code PODCAST5 to get 5% OFF at younggoose.com

Instagram: @young_goose_skincare

Most of what the supplement and skincare industry sells for aging targets one pathway at a time. But your biology does not age that way. It declines across 12 interconnected processes simultaneously, and by the time one of them shows up on your skin, the others have already been running for years.

We at Young Goose believe that skin longevity is not a topical problem. It is a whole biology problem, and the ingredients you choose, how they interact, and whether anyone has actually tested them together matters more than any single molecule ever could.

In this episode, we are joined for the second time around by Chris Mirabile, founder of NOVOS which is the first biotech company to target all 12 biological causes of aging. Chris collaborates with leading researchers at Harvard and MIT and has built his work around one premise: that real interventions require real testing on real humans, not just promising ingredients.

Let's dive in.

What's Discussed:

• (2:14) Why single ingredient marketing is a commercial story, not a scientific one.
• (9:56) The three hallmarks hitting skin hardest and how they feed each other.
• (12:02) How UV damage depletes 90% of NAD in the skin from a single exposure event.
• (22:14) Why stacking molecules requires human testing, not just ingredient research.
• (33:48) The NOVOS cardiovascular study and results that surprised the researchers.
• (48:12) Why spending more on your biology does not make your protocol safe.
• (1:02:18) What omics testing reveals that epigenetics alone cannot tell you.
• (1:09:45) Where skin longevity is heading in the next five years.

Find more from Young Goose:

• Use code PODCAST10 to get 10% OFF your first purchase, and if you’re a returning customer use the code PODCAST5 to get 5% OFF at younggoose.com
• Instagram: @young_goose_skincare

Find more from Chris Mirabile & Slow My Age:

Instagram: @slowmyage

YouTube: @slowmyage

TikTok:@slowmyage

X: @slowmyage

Personal Blog: slowmyage.com

Find more from NOVOS:

Website: NOVOSlabs.com

Instagram: @NOVOSlabs

Facebook: NOVOS

Youtube: @NOVOSlabs

TikTok: @NOVOSlabs_

X: @NOVOSLabs

Most of what goes viral on SkinTok is missing one thing. The part where someone actually checks if it works.

In this bonus episode, Amitay and Anastasia break down three of the most viral skincare trends circulating today, red light therapy wands, at-home dermarolling, and tretinoin, and run each one through a biohacker's lens. Not to dismiss them outright. But to ask the questions the original videos never do.

What is actually happening at the cellular level? What are the real risks? And where does the marketing stop and the science start?

What’s Discussed:

• (2:03) Why red light therapy wands are closer to a flashlight than a treatment.
• (4:26) What photon accumulation actually means and why moving a wand around your face defeats the purpose.
• (10:42) Why "sold out" is a marketing claim, not proof that something works.
• (14:00) What dermarolling actually does to the skin and where the real risks are.
• (15:21) Why elastin claims in skincare are almost always wrong.
• (17:06) The difference between at-home dermarolling and professional microneedling.
• (19:51) How to use a dermaroller safely if you choose to.
• (28:32) Why tretinoin makes skin worse before it gets better and what that actually means.
• (32:58) The half-life of vitamin A and why twice a week use barely moves the needle.
• (34:06) How retinoids accelerate cellular turnover but also drive senescence.
• (35:44) What can counteract the long-term tradeoffs of tretinoin use.

Check out our Mother’s Day Special:

Explore the Mother’s Day gift sets at younggoose.com/pages/mothers-day

Find more from Young Goose:

• Use code PODCAST10 to get 10% OFF your first purchase, and if you’re a returning customer use the code PODCAST5 to get 5% OFF at younggoose.com
• Instagram: @young_goose_skincare

Mothers sacrifice so much of themselves to carry another human being in their body for nine months. Even after childbirth, there's a phase called the fourth trimester because babies are still heavily dependent on moms for their survival.

Motherhood looks different for every woman. For Anastasia, who is a first-time mom, motherhood looked particularly different since her family is overseas and she's also running Young Goose with Amitay. Yet, there's something unique when a biohacker becomes a mom that new moms can learn from.

In this Young Goose Mother's Day Special, we celebrate every mother who gives selflessly to their family. We also take a peek into Anastasia's life as a new mom, what changed in her body and mindset, and how she maintained her self-care while taking care of the family and the business.

This episode will make you realize that it takes a village to raise a kid, but it takes a great mom to raise a kid and still come back to herself. Because the only way she can show up fully for others is when she can show up for herself first.

What's Discussed:

• (3:11) Who Anastasia was before motherhood: the risk-taker who crossed the world.
• (6:03) Why Anastasia loves a small circle and how she protects it.
• (10:09) Why Anastasia went back to work early, and the regret she wants other new moms to avoid.
• (12:00) Why motherhood is the hardest thing she has ever done, more than building a company.
• (15:49) How motherhood flipped the dynamic: why the assertive co-CEO becomes the soft parent.
• (25:26) Postpartum breakouts, cortisol, and why her skin told the story before anything else did.
• (29:25) What her early postpartum self-care actually looked like.
• (30:33) The non-negotiables: PEMF mat, lymphatic drainage suit, and red light therapy.
• (34:04) Anastasia's postpartum bounce-back stack: spermidine, NAD+, and PC.
• (1:58) How a biohacker reconnects with a body that no longer feels like her own.
• (4:05) The self-massage course that changed everything.
• (5:42) What self-care actually looks like in this season of motherhood.
• (10:02) Redefining energy as a mother: capacity, limits, and the cost of burnout.
• (16:01) Mindfulness as a skincare tool: why lowering cortisol shows up on your face.
• (26:06) The 20-minute practice that can stand in for hours of lost sleep.
• (27:45) The 4-7-8 breathing technique for moms who do not have 20 minutes.
• (43:28) Advice for new moms who feel self-care is unrealistic in this season.
• (43:45) The reframe that changes what self-care means for a new mom forever.

Check out our Mother’s Day Special:

Explore the Mother’s Day gift sets at https://www.younggoose.com/pages/mothers-day

Find more from Young Goose:

• Use code PODCAST10 to get 10% OFF your first purchase, and if you’re a returning customer use the code PODCAST5 to get 5% OFF at https://younggoose.com
• Instagram: @young_goose_skincare

Most of the NAD+ skincare on shelves right now is built on a misunderstanding. And if you've been trusting niacinamide to do the heavy lifting, this episode is going to change how you read a label.

This episode is Part 2 of our NAD+ deep dive. Here, we get into what actually works to raise NAD+ in the skin, the real precursors, the delivery technology that gets them where they need to go, and the mitochondrial support system most brands leave out. We also walk through the lifestyle levers that move the needle, and why one of them becomes non-negotiable for women after a certain age.

If Part 1 explains what steals your NAD+, this episode is where the science gets practical and eye-opening.

What's Discussed:

• (5:07) What the clinical data actually says about topical niacinamide
• (7:21) Why most niacinamide products on your shelf are underdosed
• (8:16) The roundabout pathway that makes niacinamide a poor NAD+ precursor
• (9:03) Niacinamide is a brightening agent, not an NAD+ booster
• (10:15) Why NMN can't cross the skin barrier alone
• (11:19) CD38 and blocking the enzyme that destroys NAD+
• (13:03) NAD+ alone is potential energy, not usable energy
• (13:45) Liposomal encapsulation and how real precursors get into the skin
• (17:02) The five mitochondrial pathways your skin actually needs
• (18:53) Senescent cells and the next telomeres conversation
• (25:17) Why NAD Apex targets NAD+ in three dimensions
• (26:39) Lifestyle strategies: fasting and the AMPK pathway
• (28:47) How to get 30 to 50% more NAD+ from caloric restriction through fasting
• (30:37) The fun fact behind why 16:8 fasting became the standard
• (33:02) HIIT and its compounding effect on baseline NAD+
• (34:51) Sleep is an NAD+ dependent repair session, not just rest
• (39:15) Your skin does 8x more renewal at night
• (41:38) Sun protection as an NAD+ strategy
• (44:49) Why you should expose your back more than your face
• (45:29) Contrast therapy, heat shock proteins, and cold-driven biogenesis
• (50:32) Why stacking NAD+ boosting activities at 50% beats maxing out one modality
• (52:49) The perimenopause problem no one is talking about
• (56:29) Why niacinamide creates homework for the body
• (1:01:46) You recycle more NAD+ daily than you can ever supplement
• (1:02:19) 5-Amino-1MQ, the peptide that recycles NAD+
• (1:05:35) Mitophagy, autophagy, and the role of spermidine
• (1:06:44) Ergothioneine, the only antioxidant with a direct mitochondrial transporter
• (1:07:46) Fermented resveratrol and activating SIRT1

Check out resources mentioned:

Part 1 of our NAD+ deep dive: The NAD+ Thief Your Skin Can't Escape: CD38, Zombie Cells, and the Decline

Check out our NAD+ Guide: NAD+ & SKIN AGING - The Cellular Energy Connection

Sleep is Skincare episode: How Timing Unlocks Your Body’s Best Skincare Repair

Find more from Young Goose:

• Use code PODCAST10 to get 10% OFF your first purchase, and if you’re a returning customer use the code PODCAST5 to get 5% OFF at https://younggoose.com
• Instagram: @young_goose_skincare
• Vampire Exosomes: Professional Exosome Serum for Regeneration and Post-Treatment Recovery https://younggoose.com/products/vampire-exosomes

A lot of us treat hair loss the way skincare treats wrinkles, as a cosmetic problem to cover up. But almost every case of thinning, recession, or shedding has something deeper driving it, and by the time it shows up in the mirror, a significant amount of density is already gone.

We at Young Goose believe that beauty is whole body care, and hair is one of the most metabolically active tissues in the body. It is also one of the first places systemic stress, hormone shifts, nutrient deficiencies, and inflammation show up.

In this episode, Dr. Alan Bauman joins us to break down the biology of hair aging and the protocols that actually move the needle. Dr. Bauman is the founder of Bauman Medical in Boca Raton and one of the pioneers of modern hair restoration, with nearly three decades of clinical practice and more than 35,000 patients treated.

His core message is simple and urgent: time equals follicles. Every week of delay is density you do not get back. And most people have no idea it is happening until the loss is already visible.

We go deeper into this in the latest episode of Biohacking Beauty: The Anti-Aging Skincare Podcast. We also cover the hidden hair loss risks of GLP-1s and testosterone optimization, the precision diagnostics replacing guesswork, and the red light therapy details almost no one talks about.

Let's dive in!

What's Discussed:

• (2:20) How Dr. Bauman became a hair restoration pioneer and the patient who changed everything.
• (9:50) Why hair is an emotional organ and a biomarker for systemic health.
• (12:14) Time equals follicles: why every week of delay costs you density.
• (13:38) The mechanism of androgenetic alopecia and how DHT miniaturizes the follicle.
• (16:30) Why DHT is not the only driver: stress, inflammation, nutrient deficiency, and GLP-1s.
• (18:55) The hidden hair loss risks of weight loss peptides and caloric deficits.
• (21:06) Precision diagnostics: AI-powered microscopy, DNA testing, and preservation first.
• (23:36) What genetic testing actually tells us about your DHT metabolism pathways.
• (29:40) Minoxidil and finasteride explained, and why oral microdose is the modern approach.
• (32:20) Dutasteride, topical finasteride, and when to escalate.
• (39:41) Copper tripeptide, zinc thymulin, and the peptides with real hair growth data.
• (42:18) The hair loss side effect of TRT and hormone optimization nobody warns you about.
• (48:09) Red light therapy for hair: the science, the studies, and what actually works.
• (52:00) Wavelength precision, power density, and why most devices will not move a follicle.
• (59:06) Why movement destroys the premise of photobiomodulation.
• (1:04:36) PRP and modern dual spin protocols for hair regeneration.
• (1:08:28) Autologous hair follicle stem cell banking and the future of restoration.

Find more from Young Goose:

• Use code PODCAST10 to get 10% off your first purchase, and if you’re a returning customer use the code PODCAST5 to get 5% off at https://younggoose.com
• Instagram: @young_goose_skincare
• Vampire Exosomes: Professional Exosome Serum for Regeneration and Post-Treatment Recovery https://younggoose.com/products/vampire-exosomes 

Find more from Dr. Alan Bauman:

Instagram: @dralanbauman

Youtube:  @AlanBaumanMD  

X: @DrAlanBauman

Facebook: Bauman Medical Group

Shop: https://dralanbauman.com/

Website: https://www.baumanmedical.com/