Hey everyone, welcome back to Biohacking Beauty! In this episode, we’re diving deep into a truth most skincare routines ignore: your environment might be aging you faster than time ever could.

We start with a story of two identical twins, same genes, same skincare habits, but drastically different aging outcomes. Why? One lived surrounded by clean nature. The other, in an urban jungle filled with air pollution, EMFs, blue light, and toxic stress. The difference wasn’t just visible, it was cellular.

In this episode, I explore how environmental stressors silently sabotage your skin by disrupting three critical biological systems. First, they deplete NAD+, second, they interfere with your epigenetic expression. And third, they impair autophagy, your body’s natural recycling system.

I’ll walk you through the Skin Longevity Matrix, a radically different framework we developed at Young Goose to reverse aging from the inside out, by supporting your skin at its biological roots, not just masking symptoms at the surface.

Let's dive in! 

I Also Discuss:

(00:02) Uncovering the Secrets of Skin Aging

(02:33) Your Skin Is a Storybook of Environmental Damage

(07:14) The 3 Silent Saboteurs Behind Premature Aging

(18:48) Revolutionizing Skin Aging With Cellular Rejuvenation

Young Goose

• Use code PODCAST10 to get 10% off your first purchase, and if you’re a returning customer use the code PODCAST5 to get 5% off at https://www.younggoose.com/ 
• Instagram: @young_goose_skincare

Most people think menopause is just about hot flashes and mood swings—but what if I told you it’s actually one of the biggest drivers of skin aging? From collagen loss to increased sensitivity, breakouts, and inflammation, hormonal shifts can make you look older, faster. And yet, no one is talking about it.

To uncover the real impact of menopause on skin health (and what you can do about it), I’m joined by Dr. Jessica Shepherd, an OB-GYN, menopause expert, and founder of Sanctum Med & Wellness. She’s on a mission to rewrite the menopause narrative, showing women how to take control of their skin, hormones, and longevity.

In this episode, we dive into the real impact of estrogen decline on skin aging, why some women experience sudden breakouts or rosacea in midlife, and how hormone replacement therapy (HRT) can play a role in both skin health and longevity. We also explore the connection between gut health, inflammation, and skin vitality, as well as the cutting-edge treatments and biohacking strategies that are changing the game for menopausal women.

Dr. Shepherd is also the author of Generation M, a book that serves as both a medical and lifestyle guide for women navigating this stage of life. She breaks down why menopause isn’t just a phase, it’s a long-term shift that requires a strategic approach to aging well.

If you’re looking for science-backed strategies to optimize your skin, hormones, and overall well-being through perimenopause and menopause, this episode is a must-listen.

We Also Discuss:

(00:02) Women's Health and Skin Aging

(09:31) Hormone Therapy and Skin Rejuvenation

(17:29) Effective Skincare Ingredients and Approaches

(21:46) Longevity and Gut Health for Skin

(31:42) Importance of Sleep for Longevity

(39:08) Future of Women's Health Therapies

(52:16) Embracing Aging With Agency and Curiosity

Learn more about:

Young Goose

• Use code PODCAST10 to get 10% off your first purchase, and if you’re a returning customer use the code PODCAST5 to get 5% off at https://www.younggoose.com/   
• Instagram: @young_goose_skincare

Dr. Jessica Shepherd

➡️ Exclusive for Biohacking Beauty Listeners

If you’re serious about optimizing your skin health and hormones, here’s something special for you: Anyone who visits Dr. Jessica Shepherd’s clinic, and mentions the Biohacking Beauty Podcast will receive a complimentary skin consultation.

• Instagram: @jessicashepherdmd​
• Twitter: @JShepherd_MD​
• LinkedIn: Jessica Shepherd, MD, MBA, FACOG​
• Book: Get Dr. Jessica Shepherd’s Book Generation M

Your skin is a reflection of your cellular health—but what if you could influence it on a deeper level? Red light therapy (photobiomodulation) is changing the way we think about aging, collagen production, and inflammation. In this episode of the Biohacking Beauty podcast, Amitay Eshel and  Anastasia Khodzhaeva, co-founders of Young Goose Skincare, break down how red light therapy impacts skin longevity, from boosting collagen to reducing inflammation. They explain what determines individual results, the common mistakes people make, and how to get the most out of this powerful technology.

But here’s the truth that not everyone knows: using red light therapy alone isn’t enough. To truly support skin regeneration, it needs the right biochemical environment. That’s where our newest LADR serum comes in—optimizing ATP production and reducing oxidative stress to help your skin work smarter. We break down exactly how to integrate this into your skincare routine, from layering antioxidants to timing your treatments for maximum benefit.

We Also Discuss:

(04:36) Why Red Light Therapy Is a Game-Changer For Your Skin

(12:48) The Skincare Ingredients That Actually Work with Red Light Therapy

(23:06) Creating a Red Light Therapy Skin Care Routine

Learn more about:

Young Goose

• Use code PODCAST10 to get 10% off your first purchase, and if you’re a returning customer use the code PODCAST5 to get 5% off at https://www.younggoose.com/ 
• Instagram: @young_goose_skincare

Welcome back to Biohacking Beauty! In this episode, we tackle the controversial topic of Botox and explore effective alternatives for those seeking more natural approaches to youthful skin. Young Goose co-founder Anastasia Khodzhaeva opens up about her personal experience with Botox treatments and why they didn't work for her, while we discuss the science behind various alternatives.

Rather than demonizing Botox, we examine both sides of this polarizing beauty topic, offering insights for those who use Botox and those looking for different options. From peptides and cellular repair compounds to professional treatments and at-home techniques, we break down what actually works when you're seeking youthful skin without neurotoxins.

Anastasia shares her journey through postpartum skin changes and how she found effective alternatives that worked for her unique situation. We also discuss how Young Goose formulations support skin regeneration at the cellular level, offering a different approach to common signs of aging. If you’ve ever wondered if Botox is for you, this is an episode you don’t want to miss. 

We Also Discuss:

(04:31) Defining what we mean by "Botox alternatives"

(06:45) Anastasia's personal journey with Botox and TMJ

(19:01) How Botox works and potential side effects

(25:17) The debate around Botox as a "preventative" treatment

(32:11) Neuropeptides and how they differ from Botox

(36:31) NAD precursors and cellular repair mechanisms

(45:20) The role of autophagy in skin rejuvenation

(45:47) Red light therapy benefits and limitations

(51:03) Facial taping, massage, and professional treatments

(56:54) Finding a balanced approach that works for you

Learn more about:

Young Goose

• Use code PODCAST10 to get 10% off your first purchase, and if you’re a returning customer use the code PODCAST5 to get 5% off at https://www.younggoose.com/ 
• Instagram: @young_goose_skincare

Hey everyone, welcome back to Biohacking Beauty! Today, we’re exploring one of the most fundamental mechanisms of aging—telomeres. These nucleotide sequences at the ends of our chromosomes act as protective caps, preserving DNA integrity during cell division. However, each time a cell replicates, telomeres shorten, eventually leading to cellular senescence, dysfunction, or apoptosis.

In this solo episode, I’m breaking down the molecular mechanisms behind telomere shortening, how factors like oxidative stress, inflammation, and metabolic dysfunction accelerate the process, and, most importantly, what we can do to slow or even reverse this decline.

We’ll dive into the latest research on NAD metabolism, autophagy, telomerase activation, and epigenetic regulation, as well as practical interventions like targeted supplementation, lifestyle modifications, and advanced skincare strategies that support telomere stability.

If you’re serious about cellular longevity, DNA repair, and optimizing your skin health at the deepest level, this episode is a must-listen.

Let’s get into it!

I Also Discuss:

(01:33 - 02:15) What Are Telomeres and Why Do They Matter?

(03:42 - 04:19) The Hidden Danger of Cellular Aging

(08:48 - 09:12) Can You Actually Reverse Telomere Shortening?

(12:45 - 13:27) Why Your Skin Shows Signs of Aging First

(10:41 - 11:12) The Best Supplements to Protect Your DNA

Learn More About

Young Goose

• Use code PODCAST10 to get 10% off your first purchase, and if you’re a returning customer use the code PODCAST5 to get 5% off at https://www.younggoose.com/ 
• Instagram: @young_goose_skincare

Today, we’re diving into a discovery that could reshape how we think about aging—C15, a newly identified essential fatty acid that plays a crucial role in cellular resilience, inflammation control, and longevity.

For decades, we’ve been told to avoid saturated fats, but what if that advice led to widespread nutritional deficiencies? Dr. Stephanie Venn-Watson, a veterinary epidemiologist and co-founder of Fatty15, uncovered C15’s role in strengthening cell membranes, reducing oxidative stress, and even influencing epigenetic aging—all from studying long-lived Navy dolphins.

In this episode, we break down how C15 protects against cellular fragility, fights ferroptosis (a newly identified form of cell death), and why it’s critical for maintaining healthy skin and metabolic function. We’ll also explore why modern diets have nearly eliminated this nutrient—and what that means for your long-term health.

Dr. Venn-Watson’s research spans over 100 peer-reviewed studies, leading to the first essential fatty acid discovery in nearly a century. Her work is redefining how we approach nutrition, longevity, and skin health at the molecular level.

We Also Discuss:

(00:01) Discovery of C15 Fatty Acid Benefits

(08:37) Importance of C15 Fatty Acid

(19:09) C15 Fatty Acid Impact on Health

(36:11) Uncovering the Role of C15

(45:10) The Case for C15 Fatty Acid

(53:48) Optimal Absorption of C15 Fatty Acid

Learn more about:

Young Goose

• Use code PODCAST10 to get 10% off your first purchase, and if you’re a returning customer use the code PODCAST5 to get 5% off at https://www.younggoose.com/ 
• Instagram: @young_goose_skincare

Stephanie and Fatty15

Website: https://fatty15.com/ 

Instagram: https://www.instagram.com/fatty15/

LinkedIn: https://www.linkedin.com/in/stephanievennwatson/ 

For years, skincare has been about quick fixes, hydration, plumping, and surface-level treatments that make your skin look better but don’t actually reverse aging. But what if the future of skincare wasn’t about temporary effects, but about reprogramming your skin at the cellular level?

In this episode of Biohacking Beauty, I take a deep dive into longevity skincare and the science behind true skin rejuvenation. We’re going beyond the outdated skincare model and breaking down the Skin Longevity Matrix, a biohacking approach designed to restore youthful function from within.

I cover why NAD+ is the "molecule of life" and a critical driver of skin repair, helping cells recover from oxidative stress and damage. We’ll explore how spermidine activates autophagy, the body’s natural detox system, to clear out aging cells and renew skin from the inside out. 

I’ll also explain the essential role of copper peptides in collagen remodeling and why they’re key for structural skin regeneration. Plus, we’ll dive into the problem with traditional vitamin C and why advanced forms like MAP and THDA provide superior antioxidant protection without causing oxidative stress. Finally, I’ll break down how eliminating senescent “zombie cells” can dramatically slow down aging and prevent chronic inflammation in the skin.

This is the next frontier of skincare—science-backed, longevity-focused, and designed to make your skin act younger, not just look younger. 

If you’re ready to upgrade your skincare routine with the latest breakthroughs in anti-aging science, this episode is for you! 

I Also Discuss:

(00:02) Biohacking Beauty

(05:18) Why NAD+ Is the Foundation of Youthful Skin

(12:56) How Spermidine Supercharges Skin Detox & Renewal

(19:09) Revitalizing Skin With Key Skincare Molecules

(27:41) The Truth About Vitamin C in Skincare

(32:23) How to Eliminate Senescent “Zombie” Cells for Younger Skin

Learn More About

Young Goose

• Use code PODCAST10 to get 10% off your first purchase, and if you’re a returning customer use the code PODCAST5 to get 5% off at https://www.younggoose.com/ 
• Instagram: @young_goose_skincare

Today, we’re diving into something that goes way beyond skincare, how your skin is actually a powerful window into your overall health and longevity. Most people think of aging as just wrinkles and fine lines, but the reality is that what’s happening on the surface is a direct reflection of what’s going on at the cellular level.

To explore this, I’m joined by Nick Engerer, a longevity scientist and the founder of A Longer Life, where he helps people take a data-driven, strategic approach to optimizing health and aging. Nick’s work is all about cutting through the noise, moving beyond trends and hype to focus on what actually works when it comes to extending healthspan and improving quality of life.

In this episode, we get into why your skin and hair are some of the most revealing biomarkers of aging, how UV exposure accelerates biological aging in ways most people don’t realize, and what you can do to slow that process down. We also tackle one of the biggest challenges in wellness today, decision fatigue. With endless options for supplements, treatments, and interventions, how do you know what’s actually worth your time and money?

Nick’s background is unique, he started as a solar radiation scientist before pivoting into longevity science, bringing a data-driven approach to proactive health. Through A Longer Life, he’s building a framework to help people apply longevity strategies in a practical, sustainable way.

If you want to learn how to take control of your skin health, optimize your longevity, and navigate the overwhelming world of wellness with confidence, this episode is for you.

We Also Discuss:

(00:00) The Essence of Biohacking

(14:36) Investing in Longevity and Skincare

(22:16) The Science of Skincare and Aging

(31:45) Reproductive Signals and Longevity Strategy

(45:03) Navigating Wellness and Longevity Overwhelm

(54:21) Optimizing Evening Routine for Wellness

(01:00:12) Exploring New Mindset Course

Learn more about:

Young Goose

• Use code PODCAST10 to get 10% off your first purchase, and if you’re a returning customer use the code PODCAST5 to get 5% off at https://www.younggoose.com/ 
• Instagram: @young_goose_skincare

Nick Engerer

For years, skincare has focused on surface-level solutions, moisturizers, retinol, collagen creams… but what if we told you that true skin rejuvenation starts at the cellular level? Traditional skincare is designed to mask aging, but new research in longevity science reveals that the root causes of aging go much deeper.

In this episode of Biohacking Beauty, I break down the real drivers of skin aging, from mitochondrial dysfunction and NAD decline to epigenetic shifts, senescent cells, and impaired autophagy. I also discuss why most anti-aging products don’t actually reverse aging, and how cutting-edge biohacking ingredients like NAD+, spermidine, copper peptides, and advanced vitamin C are changing the game.

This is the future of skincare, moving beyond temporary fixes and truly reprogramming skin cells for longevity. 

If you’ve ever wondered why your skin isn’t responding to traditional skincare, or how you can actually slow down and even reverse the aging process, this episode is for you!

I Also Discuss:

(00:01) The Science of Ageless Skin

(04:54) Your Mitochondria Are Aging Your Face

(12:21) Can You Actually Reverse Skin Aging?

(17:21) The Truth About Skincare Lies

Learn More About

Young Goose

• Use code PODCAST10 to get 10% off your first purchase, and if you’re a returning customer use the code PODCAST5 to get 5% off at https://www.younggoose.com/ 
• Instagram: @young_goose_skincare

Welcome back to Biohacking Beauty! Today, we’re diving into the cutting-edge science of biological vs. chronological aging and how epigenetic testing is revolutionizing the way we understand skin longevity. Aging isn’t just about the number of birthdays you’ve had—it’s about how your cells are aging at the molecular level. And now, thanks to advancements in epigenetics and AI-driven diagnostics, we can measure and even influence that process.

In this episode, I sit down with Hannah Went, an expert in biological age testing and the Director of Operations at TruDiagnostic, a leading epigenetics company. We explore how biological aging manifests in the skin, why epigenetic markers are more predictive of health than genetics, and how personalized interventions can actually slow or even reverse aging at the cellular level.

Hannah also shares groundbreaking research on how lifestyle choices, like diet, sleep, and even skincare, can alter gene expression and influence the rate at which we age. Plus, we discuss how advanced testing methods can provide real-time feedback on how well anti-aging interventions are actually working. If you’ve ever wanted to take a data-driven approach to longevity, this episode is packed with insights you won’t want to miss.

Hannah Went is the Director of Operations at TruDiagnostic, a company at the forefront of biological age testing and longevity research. With a background in epigenetics and functional medicine, she’s dedicated to helping individuals track and optimize their health using cutting-edge diagnostic tools.

We Also Discuss:

(00:01) Epigenetics and Biological Age Testing

(13:47) Aging and Skin Link Exploration

(26:13) Genetic Influence on Phenotype and Aging

(31:37) Aging, Skin Health, and Lifestyle Factors

(44:43) At-Home Genetic Testing Support

Learn more about:

Young Goose

• Use code PODCAST10 to get 10% off your first purchase, and if you’re a returning customer use the code PODCAST5 to get 5% off at https://www.younggoose.com/ 
• Instagram: @young_goose_skincare

Hannah Went

• Website: everythingepigenetics.com 
• Instagram: @everythingepigenetics