Rob and Rev Run are kindred spirits! The legendary rapper, DJ, and minister Rev Run joins Rob Lowe to discuss the incredible legacy of his group Run-DMC, growing up in the sixties and seventies, focusing on family, finding inspiration in the tub, and the new Peacock docuseries, "Kings From Queens: The Run DMC Story.”

Got a question for Rob? Call our voicemail at (323) 570-4551. Your question could get featured on the show!

Cheryl and Rob have so much to catch up on! Cheryl Hines joins Rob Lowe to discuss the final season of “Curb Your Enthusiasm,” Larry David’s run-in with Elmo, how she would dress as First Lady, choosing your Secret Service code-name, Cheryl’s mom’s birthday at Thunder Down Under, and much more. 

Got a question for Rob? Call our voicemail at (323) 570-4551. Your question could get featured on the show!

In honor of her 70th birthday, Rob is looking back at his 2021 conversation with the amazing Oprah Winfrey! The two friends discuss what it means to live in gratitude, the wisdom of Toni Morrison, meeting your heroes, and so much more.

Got a question for Rob? Call our voicemail at (323) 570-4551. Your question could get featured on the show!

Rob and filmmaker Ed Zwick have so many great memories from shooting their 1986 film “About Last Night!” Filmmaker Ed Zwick (creator of “thirtysomething” and director of “The Last Samurai” and “Legends of the Fall”) joins Rob to revisit “About Last Night,” and discuss Ed’s work with Tom Cruise, the death of a certain kind of adult drama film, advice from Morgan Freeman, and Ed’s new book, “Hits, Flops, and Other Illusions: My Fortysomething Years in Hollywood” (out February 13th).

Got a question for Rob? Call our voicemail at (323) 570-4551. Your question could get featured on the show!

Rob wouldn't mind swapping lives with Hollywood legend Brian Grazer for a day! The prolific film and TV producer (whose credits include “24,” “Arrested Development,” “Apollo 13,” and “A Beautiful Mind”) joins Rob to discuss the future of Hollywood, how to revamp the Oscars ceremony, the differing worldviews of “The West Wing” and “24,” his book on the power of face-to-face conversation, and his latest film, “Candy Cane Lane” with Eddie Murphy. 

Got a question for Rob? Call our voicemail at (323) 570-4551. Your question could get featured on the show!

It’s a love-fest when old friends Robert Downey Jr. and Rob Lowe get together! Rob is talking to his former high school classmate and longtime friend: the great Robert Downey Jr. Hear them discuss their shared memories from Santa Monica High School, surviving the 1980s, the genius of Christopher Nolan, and growing from set-backs.

Robert’s latest film, “Oppenheimer,” is available now on 4K, Blu-Ray, DVD & Digital. His book, "Cool Food: Erasing Your Carbon Footprint One Bite at a Time" (written with Thomas Kostigen), is out on January 23!

Got a question for Rob? Call our voicemail at (323) 570-4551. Your question could get featured on the show!

Ted Danson and Rob Lowe have watched the entertainment industry transform! Ted Danson joins Rob Lowe to discuss the incredible legacy of “Cheers,” the optimistic comedy of “The Good Place” and “Parks & Recreation,” his experiences working with Steven Spielberg and Larry David, learning that his show was canceled while touring the Sistine Chapel, and the importance of protecting our oceans.

Got a question for Rob? Call our voicemail at (323) 570-4551. Your question could get featured on the show!

When Darius Rucker and Rob Lowe get together, it's time to talk sports and music! Darius Rucker joins Rob Lowe to discuss the early days of Hootie & the Blowfish, the compliment he received from Frank Sinatra, why “Wagon Wheel” is so undeniable (and the song’s surprising co-writer), Darius’ new sports swag collection with Fanatics, and his upcoming Hootie & the Blowfish anniversary tour. Plus, Rob tells us his go-to karaoke songs.

Got a question for Rob? Call our voicemail at (323) 570-4551. Your question could get featured on the show!

As a holiday gift to his Literally listeners, Rob is revisiting one of his all-time favorite episodes: his 2021 chat with Molly Ringwald! Hear them discuss her iconic work with John Hughes, Rob’s audition for “The Breakfast Club,” Bop! vs Time Magazine, how she found her voice as a writer, and much more!

This episode originally aired 8/2/2021. 

Got a question for Rob? Leave a 30-second voicemail at (323) 570-4551. Your question could get featured on the show!

Jerry O’Connell and Rob Lowe never stopped hustling! Actor and host Jerry O’Connell joins Rob Lowe to discuss his unexpected path to daytime television, their similar experiences shooting "Stand By Me" and "The Outsiders," raising teenagers in a changing world, the career insecurities that never go away, his new season of “The Talk,” and much more. Plus, Rob talks about his Christmas movie, "Holiday in the Wild."

Got a question for Rob? Leave a 30-second voicemail at (323) 570-4551. Your question could get featured on the show!