In March's podcast, James Cave (DTB Editor-in-Chief) and David Phizackerley (DTB Deputy Editor) get excited about the impact that the results of the Direct study could have on the management of type 2 diabetes. The editors also discuss the combination of doxylamine and pyridoxine for the treatment of nausea and vomiting in pregnancy and consider the role of primary care in supporting patients who are taking clozapine.