In this podcast, James Cave (Editor-in-Chief) and David Phizackerley (Deputy Editor) review the March issue of DTB (https://dtb.bmj.com/content/59/3). The editorial discusses a national safety alert that highlighted the risk of dependence associated with prolonged use of opioids for non-cancer pain and a proposal that all opioid medicines in the UK carry the warning "can cause addiction" (https://dtb.bmj.com/content/59/3/34). The editors talk about an article on the rationale and science behind bisphosphonate holidays (https://dtb.bmj.com/content/59/3/35). The main article explores the risk of nitrosamine contamination in medicines (https://dtb.bmj.com/content/59/3/39) and the case report is of a patient who developed an unusually impressive atorvastatin-induced elevation of serum alkaline phosphatase (https://dtb.bmj.com/content/59/3/43).

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