Our host Dr. Kevin Shah discusses with three expert clinicians (Dr. Eileen Hsich, Dr. Ersilia DeFilippis, & Dr. Kathleen Faulkenberg) the impact of marijuana use for our patients being considered or who have undergone heart transplantation. The discussants review the evolving literature and changing landscape of recreational as well as medicinal marijuana and the potential impact on drug interactions, adherence, and outcomes after heart transplantation.