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An 84-year-old woman vanishes from her Arizona home overnight — and deputies say she did NOT leave on her own. The house is now an active crime scene, homicide detectives are involved, and Nancy Guthrie's life-saving medication is still inside.

Tonight we break down the timeline, the evidence, what investigators have revealed so far, and why this case is different from the usual "missing senior" narrative.

If you have ANY information on the disappearance of Nancy Guthrie, contact the Pima County Sheriff's Office at 520-351-4900.

Stay until the end – we talk about what we know, what's still speculation, and what needs to happen next.

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