In this NEJM Outbreaks Update, Editor-in-Chief Eric Rubin and Deputy Editor Lindsey Baden are joined by veterinarian and virologist Yoshihiro Kawaoka to discuss avian influenza and its current impact on chickens, cows, cats, and humans. Eric Rubin is the Editor-in-Chief of the Journal. Lindsey Baden is a Deputy Editor of the Journal. Yoshihiro Kawaoka is a veterinarian and virologist and a professor at the University of Wisconsin-Madison and the University of Tokyo. Stephen Morrissey, the interviewer, is the Executive Managing Editor of the Journal. E.J. Rubin and Others. NEJM Outbreaks Update — H5N1. N Engl J Med. DOI: 10.1056/NEJMe2502267.