The past 30 years have produced an epidemic of obesity -- mostly because evolution did not prepare us for so many calories and so little physical activity.

Dr. Louis Aronne, a leading authority on obesity, explains how a period of caloric excess can damage the neural connections that manage your metabolism, throwing your weight regulation out of whack. More importantly, he talks about the new drug that tackles obesity at two different hormonal sites and promises to become an actual "weight loss pill."

Plus... the real reason to skip the bread basket (it's in your brain)