Welcome to the third episode of our three-part series on colorectal cancer! In this episode of the Oncology Brothers we are joined by Dr. Rona Yaeger, a medical oncologist from the Memorial Sloan Kettering Cancer Center. Together, we dived into the management of common side effects associated with systemic treatments for colorectal cancer.
• Overview of 5-FU and capecitabine, including the importance of DPYD mutation testing and side effects like cytopenia, mucositis, and cardiac toxicity.
• Discussion on the use of 5-FU bolus in both metastatic and adjuvant settings.
• Insights into managing oxaliplatin-induced neuropathy and the potential benefits of oral cryotherapy.
• Clinical pearls for irinotecan, including the management of diarrhea and cholinergic effects.
• Considerations for using Bevacizumab, including risks of hypertension, proteinuria, and blood clots.
• Tips for managing side effects of anti-EGFR agents like Cetuximab and Panitumumab, including rash and infusion reactions.
• An overview of oral agents such as encorafenib, TAS-102, and Regorafenib, with a focus on dosing strategies and side effect management.
Join us as we explore these critical topics and provide valuable insights for healthcare professionals managing colorectal cancer treatments.
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