OPENPediatrics

Listen as Dr. Adrienne Randolph discusses the epidemiology, clinical characteristics, and outcomes observed in pediatric patients diagnosed with Severe Acute COVID-19 and Multisystem Inflammatory Syndrome in Children (MIS-C). She shares insights into patient features that can help distinguish between these conditions, potentially facilitating the delivery of timely and effective therapies.

After this podcast, listeners will be able to:

• Contrast the key clinical characteristics of children and adolescents diagnosed with MIS-C versus severe acute COVID-19

• Describe key concerns relating to pediatric COVID-19 vaccine development and pediatric public health measures such as school reopening

Articles referenced:

• Feldstein LR, Tenforde MW, Friedman KG, et al. Characteristics and Outcomes of US Children and Adolescents With Multisystem Inflammatory Syndrome in Children (MIS-C) Compared With Severe Acute COVID-19. JAMA. 2021;325(11):1074-1087. doi:10.1001/jama.2021.2091 (00:47)

• Ferdinands JM, Olsho LE, Agan AA, et al. Effectiveness of influenza vaccine against life-threatening RT-PCR-confirmed influenza illness in US children, 2010-2012. J Infect Dis. 2014;210(5):674-683. doi:10.1093/infdis/jiu185 (01:42)

• Feldstein LR, Rose EB, Horwitz SM, et al. Multisystem Inflammatory Syndrome in U.S. Children and Adolescents. N Engl J Med. 2020;383(4):334-346. doi:10.1056/NEJMoa2021680 (02:59)

• Truong DT, Trachtenberg FL, Pearson GD, et al. The NHLBI Study on Long-terM OUtcomes after the Multisystem Inflammatory Syndrome In Children (MUSIC): Design and Objectives. Am Heart J. 2022;243:43-53. doi:10.1016/j.ahj.2021.08.003 (11:52)

• LaRovere KL, Riggs BJ, Poussaint TY, et al. Neurologic Involvement in Children and Adolescents Hospitalized in the United States for COVID-19 or Multisystem Inflammatory Syndrome. JAMA Neurol. 2021;78(5):536-547. doi:10.1001/jamaneurol.2021.0504 (17:53)

Initial publication: March 23, 2021.

Speakers:

Adrienne Randolph, MD, MSc

Senior Associate in Critical Care Medicine

Department of Anesthesiology, Critical Care and Pain Medicine

Boston Children's Hospital

Professor of Anaesthesia

Harvard Medical School

Jeffrey Burns, MD, MPH

Chief and Shapiro Chair, Critical Care Medicine,

Executive Chair, International Health Services,

Director, OPENPediatrics,

Senior Associate in Critical Care Medicine, Department of Anesthesiology, Critical Care and Pain Medicine,

Boston Children's Hospital

Professor of Anesthesia, Harvard Medical School

Citation:

Randolph A, Zackin B, Daniel D, Burns JP. Characteristics and Outcomes of Children with MIS-C Compared With Severe Acute COVID-19. 3/2021. Online Podcast. OPENPediatrics. https://soundcloud.com/openpediatrics/characteristics-and-outcomes-of-children-with-mis-c-compared-with-severe-acute-covid-19.

This recording is intended to be used as an educational resource for healthcare providers. It is in no way a substitute for the independent decision making and judgment of a qualified healthcare professional. It should not be used to make a diagnosis, or to overrule the advice of a qualified health care provider, nor should it be used to provide advice for emergency medical treatment.

Please visit: www.openpediatrics.org

This podcast discusses how to assess and provide localized wound care for a pressure injury, and includes a demonstration of how to clean and dress a pressure injury in the low resource setting.

Learning Objectives:

1. Identify principles of pressure injury treatment

2. List types of wound care products that may be used to dress a pressure injury wound

3. Demonstrate proper technique for cleaning and dressing a pressure injury wound

Initial Publication Date: 3/17/2021

Please visit: http://www.openpediatrics.org

OPENPediatrics™ is an interactive digital learning platform for healthcare clinicians sponsored by Boston Children’s Hospital and in collaboration with the World Federation of Pediatric Intensive and Critical Care Societies. It is designed to promote the exchange of knowledge between healthcare providers around the world caring for critically ill children in all resource settings. The content includes internationally recognized experts teaching the full range of topics on the care of critically ill children. All content is peer-reviewed and open access-and thus at no expense to the user. For further information on how to enroll, please email: [email protected]

Listen as Dr. Michael Manfredi reviews how to assess a patient with gastrointestinal bleeding, including how to identify different etiologies, and reviews lab and treatment options.

Initlal publication: March 10, 2021.

Please visit: www.openpediatrics.org

OPENPediatrics™ is an interactive digital learning platform for healthcare clinicians sponsored by Boston Children's Hospital and in collaboration with the World Federation of Pediatric Intensive and Critical Care Societies. It is designed to promote the exchange of knowledge between healthcare providers around the world caring for critically ill children in all resource settings. The content includes internationally recognized experts teaching the full range of topics on the care of critically ill children. All content is peer-reviewed and open access-and thus at no expense to the user.

For further information on how to enroll, please email: [email protected]

By the end of this podcast, the viewer will be able to understand the basic pathophysiology of diarrhea, describe the clinical presentation in a pediatric patient, develop a diagnosis for a child with diarrhea, and explain the management of diarrhea in children.

Initial Publication Date: March 3, 2021.

Please visit: http://www.openpediatrics.org OPENPediatrics™ is an interactive digital learning platform for healthcare clinicians sponsored by Boston Children’s Hospital and in collaboration with the World Federation of Pediatric Intensive and Critical Care Societies. It is designed to promote the exchange of knowledge between healthcare providers around the world caring for critically ill children in all resource settings. The content includes internationally recognized experts teaching the full range of topics on the care of critically ill children. All content is peer-reviewed and open access-and thus at no expense to the user.For further information on how to enroll, please email: [email protected]

In this edition of the World Shared Practice Forum podcast, Dr. Petter Brodin, Consultant in Pediatric Immunology at the Karolinska Institute, discusses new and emerging knowledge regarding the immune response to SARS-CoV-2 infection. He also provides perspective on the immunology of the COVID-19 vaccine response, as well as the Multisystem Inflammatory Syndrome in Children (MIS-C).

After this podcast, listeners will be able to:

• Discuss the current understanding of COVID-19 immunology

• Understand immune system responses that may influence COVID-19 disease burden and severity

• Describe current theories of the immunology of the COVID-19 Multisystem Inflammatory Syndrome in Children (MIS-C)

Initial publication: February 22, 2021.

Speakers:

Petter Brodin, MD, PhD

Consultant in Pediatric Immunology, Karolinska University Hospital

Professor of Pediatric Immunology, Karolinska University

Jeffrey Burns, MD, MPH

Chief and Shapiro Chair, Critical Care Medicine,

Executive Chair, International Health Services,

Director, OPENPediatrics,

Senior Associate in Critical Care Medicine, Department of Anesthesiology, Critical Care and Pain Medicine,

Boston Children's Hospital

Professor of Anesthesia, Harvard Medical School

Citation:

Brodin P, Zackin B, Daniel D, Burns JP. Immune determinants of COVID-19 disease presentation and severity. 2/2021. Online Podcast. OPENPediatrics. https://youtu.be/dFA68r40UMU.

Resources:

• Brodin P. Immune determinants of COVID-19 disease presentation and severity. Nature Medicine. 2021 Jan;27(1):28-33.

• Consiglio CR, Cotugno N, Sardh F, Pou C, Amodio D, Rodriguez L, Tan Z, Zicari S, Ruggiero A, Pascucci GR, Santilli V, Brodin P. The immunology of multisystem inflammatory syndrome in children with COVID-19. Cell. 2020 Nov 12;183(4):968-81.

• Bastard P, Rosen LB, Zhang Q, Michailidis E, Hoffmann HH, Zhang Y, Dorgham K, Philippot Q, Rosain J, Béziat V, Manry J, Brodin P, et al. Autoantibodies against type I IFNs in patients with life-threatening COVID-19. Science. 2020 Oct 23;370(6515).

• Rodriguez L, Brodin P. Unraveling the Immune Response in Severe COVID-19. Journal of clinical immunology. 2020 Oct;40(7):958-9.

This recording is intended to be used as an educational resource for healthcare providers. It is in no way a substitute for the independent decision making and judgment of a qualified healthcare professional. It should not be used to make a diagnosis, or to overrule the advice of a qualified health care provider, nor should it be used to provide advice for emergency medical treatment.

Please visit: www.openpediatrics.org

OPENPediatrics™ is an interactive digital learning platform for healthcare clinicians sponsored by Boston Children's Hospital and in collaboration with the World Federation of Pediatric Intensive and Critical Care Societies. It is designed to promote the exchange of knowledge between healthcare providers around the world caring for critically ill children in all resource settings. The content includes internationally recognized experts teaching the full range of topics on the care of critically ill children. All content is peer-reviewed and open access-and thus at no expense to the user.

For further information on how to enroll, please email: [email protected]

Listen as Dr. Gary Dhillon presents on Long QT syndrome and pearls for anesthesiologists and intensivists.

Initial publication: February 9, 2021.

Please visit: www.openpediatrics.org

OPENPediatrics™ is an interactive digital learning platform for healthcare clinicians sponsored by Boston Children's Hospital and in collaboration with the World Federation of Pediatric Intensive and Critical Care Societies. It is designed to promote the exchange of knowledge between healthcare providers around the world caring for critically ill children in all resource settings. The content includes internationally recognized experts teaching the full range of topics on the care of critically ill children. All content is peer-reviewed and open access-and thus at no expense to the user.

For further information on how to enroll, please email: [email protected]

Listen as Dr. Gary Dhillon discusses Brugada syndrome and pearls for the anesthesiologist and intensivist.

Initial publication: February 9, 2021.

Please visit: www.openpediatrics.org

OPENPediatrics™ is an interactive digital learning platform for healthcare clinicians sponsored by Boston Children's Hospital and in collaboration with the World Federation of Pediatric Intensive and Critical Care Societies. It is designed to promote the exchange of knowledge between healthcare providers around the world caring for critically ill children in all resource settings. The content includes internationally recognized experts teaching the full range of topics on the care of critically ill children. All content is peer-reviewed and open access-and thus at no expense to the user.

For further information on how to enroll, please email: [email protected]

Listen as Dr. Gary Dhillon reviews Wolff-Parkinson-White syndrome and pearls for the anesthesiologist and intensivist.

Initial publication: February 9, 2021.

Please visit: www.openpediatrics.org

OPENPediatrics™ is an interactive digital learning platform for healthcare clinicians sponsored by Boston Children's Hospital and in collaboration with the World Federation of Pediatric Intensive and Critical Care Societies. It is designed to promote the exchange of knowledge between healthcare providers around the world caring for critically ill children in all resource settings. The content includes internationally recognized experts teaching the full range of topics on the care of critically ill children. All content is peer-reviewed and open access-and thus at no expense to the user.

For further information on how to enroll, please email: [email protected]

In this podcast, Dr. Rick Malley, Senior Physician in Pediatrics at the Boston Children's Hospital Division of Infectious Diseases, discusses the current research on COVID-19 vaccination efforts. He discusses the safety and efficacy of the currently-approved vaccines developed by Pfizer, Moderna, and AstraZeneca, as well as some upcoming vaccines. He discusses the impact on the transmission of the virus and outlines some of the controversies and gaps of knowledge still present in research, as well as some of the challenges of making the vaccine available on a global scale.

After this podcast, listeners will be able to:

• Distinguish the differences between currently-approved COVID-19 vaccines

• Understand the knowledge gaps and controversies in current vaccine research

• Gain a broader picture of global delivery implications related to COVID-19 vaccinations

Initial publication: January 22, 2021.

Speakers:

Rick Malley, MD

Senior Physician in Pediatrics, Division of Infectious Diseases, Boston Children’s Hospital

Professor of Pediatrics, Harvard Medical School

Jeffrey Burns, MD, MPH

Chief and Shapiro Chair, Critical Care Medicine,

Executive Chair, International Health Services,

Director, OPENPediatrics,

Senior Associate in Critical Care Medicine, Department of Anesthesiology, Critical Care and Pain Medicine,

Boston Children's Hospital

Professor of Anesthesia, Harvard Medical School

Citation:

Malley R, Zackin B, Wolbrink TA, Burns JP. Updates on COVID-19 Vaccines. 01/2021. Online Podcast. OPENPediatrics. https://soundcloud.com/openpediatrics/updates-on-covid-19-vaccines.

This recording is intended to be used as an educational resource for healthcare providers. It is in no way a substitute for the independent decision making and judgment of a qualified healthcare professional. It should not be used to make a diagnosis, or to overrule the advice of a qualified health care provider, nor should it be used to provide advice for emergency medical treatment.

Please visit: www.openpediatrics.org

OPENPediatrics™ is an interactive digital learning platform for healthcare clinicians sponsored by Boston Children's Hospital and in collaboration with the World Federation of Pediatric Intensive and Critical Care Societies. It is designed to promote the exchange of knowledge between healthcare providers around the world caring for critically ill children in all resource settings. The content includes internationally recognized experts teaching the full range of topics on the care of critically ill children. All content is peer-reviewed and open access-and thus at no expense to the user.

For further information on how to enroll, please email: [email protected]

Listeners will learn how this team supported and educated frontline staff about how to provide safe care of themselves, patients, and families during the COVID-19 crisis.

Initial publication: January 15, 2021.

Please visit: www.openpediatrics.org

OPENPediatrics™ is an interactive digital learning platform for healthcare clinicians sponsored by Boston Children's Hospital and in collaboration with the World Federation of Pediatric Intensive and Critical Care Societies. It is designed to promote the exchange of knowledge between healthcare providers around the world caring for critically ill children in all resource settings. The content includes internationally recognized experts teaching the full range of topics on the care of critically ill children. All content is peer-reviewed and open access-and thus at no expense to the user.

For further information on how to enroll, please email: [email protected]