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Rewiring Dry Eyes: Nasal Spray Boosts Tears in Sjögren’s
 In this episode, we unpack a 2025 pilot study from the University of Pennsylvania that tested varenicline nasal spray for dry eye disease in Sjögren’s patients. Learn how neural stimulation through the nose improved tear production, reduced inflammation, and offered new hope for one of ophthalmology’s most challenging autoimmune conditions.

Source: Gupta AS et al., Clinical Ophthalmology. 2025;19:1073–1084. DOI: 10.2147/OPTH.S512364.

LINK: Varenicline solution nasal spray for the treatment of dry eye disease | OPTH

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About Ran Yam:

Ran Yam, CEO and co-founder.

Ran has decades of experience in developing optical systems and medical devices for different industries such as defense, optical communication, semi-conductors and ophthalmology . In his previous position as VP R&D for Visionix, a global leader in eye care solutions, he was responsible for developing innovative, cutting edge eye diagnostics products that are available globally. Ran holds a BSc in Mechanical Engineering (Cum Laude) from the Israeli Technion and has nine patents to his name.

Novasight: https://nova-sight.com/

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Dry eye diagnosis has entered a new era. In this episode, Dr. Kading breaks down the Tear Film & Ocular Surface Society’s DEWS III Diagnostic Methodology Report (2025)  explaining how the new definition, streamlined tests, and driver-based model are transforming clinical practice. Learn what’s changed since DEWS II, why OSDI-6 is now the global standard, and how a single diagnostic framework can unify patient care around the world.

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About Dr. Dunn 

Dr. Dunn graduated from Pacific University College of Optometry in 2013 and then completed a residency at the Roseburg VA in Roseburg, Oregon specializing in geriatric care and ocular disease. After completing her residency, she opened a private practice as well as becoming an assistant professor at Pacific’s College of Optometry. Dr. Dunn provides comprehensive and medical eye exams for the entire family, with a specialty in dry eye disease.

Since the start of optometry school, Dr. Dunn has been highly active in organized optometry. As a student she represented her school on the AOSA Board of Trustees, and in her fourth year of school was elected the Vice President of all the optometry schools in North America. Since graduation she has served on several committees within the American Optometric Association, served five years on the board for the Oregon Optometric Physicians Association and is the Executive Director for the Arizona Optometric Association.

Dr. Dunn was awarded Young OD of the year for Oregon in 2018, the American Optometric Association Media Advocacy Award in 2022 and the Social Media award in 2023 in Oregon.

When not seeing patients, Dr. Dunn enjoys spending time traveling with her husband and kids or surrounding herself with other women of faith in adventures.

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