The ketogenic (keto) diet has surged in popularity, with many touting its weight loss and metabolic benefits. However, some individuals—particularly those following a low-carb, high-fat regimen—experience a significant rise in LDL cholesterol, a phenomenon now known as the Lean Mass Hyper-Responder (LMHR) phenotype. What does this mean for cardiovascular risk?

In this episode, Chadi is joined by three of the lead investigators of the KETO-CTA study, recently published in The American Journal of Clinical Nutrition. They break down their findings on how the keto diet affects coronary plaque formation and what it could mean for LMHR individuals.

This is Part 1 of a two-part series. Next week, Chadi brings in a contrasting perspective on the study’s conclusions.

A must-listen series for anyone interested in the intersection of diet, cholesterol, and cardiovascular health.

View the KETO-CTA study.

https://www.sciencedirect.com/science/article/pii/S2772963X25001036

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