PeerView Family Medicine & General Practice CME/CNE/CPE Audio Podcast

Go online to PeerView.com/QQN860 to view the activity, download slides and practice aids, and complete the post-test to earn credit. In this activity, an expert in neurology discusses the current clinical data and practical application of disease-modifying therapies in the management of patients with spinal muscular atrophy. Upon completion of this activity, participants should be better able to: Identify spinal muscular atrophy (SMA) through newborn screening and/or recognition of symptoms and signs, Apply current evidence on the efficacy, safety, and tolerability of approved disease-modifying therapies in the treatment of SMA, Counsel caregivers and/or patients regarding the need for monitoring and supportive care to optimize treatment outcomes in SMA.

Go online to PeerView.com/HKY860 to view the activity, download slides and practice aids, and complete the post-test to earn credit. In this activity, a leading expert in the management of acute hepatic porphyria (AHP) discusses recent evidence and recommendations for treating AHP and highlights the rationale and role of a new siRNA-based therapeutic option. Upon completion of this activity, participants should be better able to: Recognize AHP and associated disease burdens that may be experienced by patients (eg, health impact, quality of life, daily activities), Describe evidence-based interventions for AHP, including the rationale and trial data for recently approved siRNA therapy, Apply evidence-based diagnostic and treatment approaches to minimize disease impact and burden for individuals with AHP.

Go online to PeerView.com/WUH860 to view the activity, download slides and practice aids, and complete the post-test to earn credit. In this activity, an expert in dermatology discusses contemporary approaches to improve the care of patients with moderate to severe alopecia areata. Upon completion of this activity, participants should be better able to: Recognize the burden of disease and unmet needs experienced by patients with moderate to severe alopecia areata, Discuss the rationale for JAK inhibition as a treatment approach to alopecia areata, Compare and contrast novel JAK inhibitors for the treatment of moderate to severe alopecia areata in the context of selectivity, efficacy, and safety, Treat moderate to severe alopecia areata in accordance with current evidence and expert recommendations, identifying patients who would likely derive benefit from novel nonbiologic oral therapeutic options.

Go online to PeerView.com/ECW860 to view the activity, download slides and practice aids, and complete the post-test to earn credit. In this activity, an expert in dermatology discusses the role of IL-17 inhibitors in the treatment of psoriasis. Upon completion of this activity, participants should be better able to: Discuss the impact of psoriasis on patient quality of life, Outline the role of IL-17 in the pathophysiology of psoriasis, Assess data regarding the efficacy and safety of IL-17 inhibitors for the treatment of moderate to severe psoriasis, Incorporate agents targeting IL-17 into appropriate and effective treatment plans for individual patients with moderate to severe psoriasis.

Go online to PeerView.com/UNQ860 to view the activity, download slides and practice aids, and complete the post-test to earn credit. In this activity, a nephrology expert discusses the latest evidence for hypoxia-inducible factor prolyl-hydroxylase (HIF-PH) inhibitors for the treatment of anemia associated with chronic kidney disease (CKD). Upon completion of this activity, participants will be able to: Describe the epidemiology, pathology, and burden of anemia associated with CKD, Discuss key limitations associated with the current model of treatment for anemia associated with CKD, including in patients with NDD-CKD and DD-CKD, Explain the rationale for and potential implications of targeting HIF stabilization with HIF-PH inhibitors as a treatment strategy for anemia in CKD.

Go online to PeerView.com/PVT860 to view the activity, download slides and practice aids, and complete the post-test to earn credit. In this activity, an expert in type 2 diabetes (T2DM) management discusses how to individualize treatment with GLP-1 RAs to improve outcomes for patients. Upon completion of this activity, participants should be better able to: Apply evidence-based treatment recommendations for GLP-1 RAs based on clinical trial results evaluating glycemic and extra-glycemic (eg, cardiovascular risk reduction, weight education) outcomes in patients with T2DM, Identify potential barriers to use (ie, mode of administration, adverse events) for current and emerging GLP-1 RAs, Engage in patient-centered discussions about the benefits and risks of using GLP-1 RAs to personalize management of T2DM.

Go online to PeerView.com/URQ860 to view the activity, download slides and practice aids, and complete the post-test to earn credit. In this activity, a vascular medicine expert discusses real-world evidence (RWE) for treating patients with or at risk for venous thromboembolism (VTE) with direct oral anticoagulants (DOACs). Upon completion of this activity, participants will be able to: Explain the role of RWE and the impact it may have on improving care and outcomes in patients with VTE, Assess the quality and validity of the evidence collected as part of real-world studies comparing the DOACs with warfarin in patients with VTE (eg, efficacy, safety, cost-effectiveness, quality of life), Incorporate RWE into clinical decision-making for patients with VTE to design individualized treatment plans, especially for patients who may not be well represented in randomized clinical trials.

Go online to PeerView.com/FMQ860 to view the activity, download slides and practice aids, and complete the post-test to earn credit. Alzheimer’s disease (AD) is a devastating yet highly prevalent condition, affecting 10% of people older than 65 years and increasing in global prevalence as the world’s population ages. Given the heavy economic and societal burdens of AD, major emphasis has been placed on finding disease-modifying therapies that can successfully delay or prevent the progression of AD. Although several hypotheses have been proposed regarding the causes of AD, the amyloid cascade hypothesis and the tau propagation hypothesis have gained the most support, and there are many novel agents under investigation for the treatment of AD that target Aβ or tau in a variety of ways. Recent advances have also been made in identifying and testing biomarkers for AD that may aid in the early diagnosis of disease, facilitate patient selection for treatment, and monitor therapeutic response. This accredited PeerView on-demand activity is based on a virtual meeting that utilized the innovative Pando™ platform. A multidisciplinary panel of AD experts provides an engaging discussion on the early recognition and diagnosis of AD, current and emerging treatment options and biomarkers, and optimal multidisciplinary management of patients with AD. They also explore ways in which different members of the multidisciplinary team can help to accommodate the influx of new treatable patients that will flood the healthcare system once a disease-modifying therapy is approved for AD. Upon completion of this activity, participants will be able to: Describe the rationale for screening for mild cognitive impairment (MCI) to identify patients at risk for AD early in the disease course, Apply validated neuroimaging techniques and biomarkers to make etiologically based diagnoses of AD, Assess key data sets on the efficacy, safety, and tolerability of available and emerging therapies for the treatment of AD, Employ a multidisciplinary team-based approach to manage the influx of patients that will need to be screened, diagnosed, and treated once a disease-modifying therapy is approved in AD.

Go online to PeerView.com/SZJ860 to view the activity, download slides and practice aids, and complete the post-test to earn credit. In this activity, an expert in psychiatry discusses the use of GABA-modulating neuroactive steroids as rapid-acting antidepressants. Upon completion of this activity, participants should be better able to: Discuss the role of GABAergic dysfunction in PPD and MDD and the rationale for therapeutic targeting of GABA-A receptors with neuroactive steroids; Review the current treatment landscape and unmet needs of patients with MDD; Identify key barriers to the diagnosis and management of PPD; Apply recent evidence on the efficacy and safety of approved and emerging neuroactive steroids to the management of patients with PPD and MDD.

Go online to PeerView.com/KXM860 to view the activity, download slides and practice aids, and complete the post-test to earn credit. In this case-based activity, experts in oncology and primary care examine how to best integrate future blood-based cancer screening tools into clinical practice in order to reduce cancer-related morbidity and mortality. Upon completion of this activity, participants should be better able to: Explain the scientific principles behind cfDNA-based liquid biopsy as a tool for early cancer screening, including the strengths and limitations of liquid biopsy compared with those of conventional screening methods, Identify the diagnostic/screening role of novel cfDNA-based screening assays for early cancer detection in the primary care setting, Adapt current cancer screening protocols based on recent evidence on emerging cfDNA-based multicancer screening assays in order to improve sensitivity, specificity, and tumor localization accuracy, Employ patient-centered strategies to integrate novel cancer screening methodologies in the primary care setting, including as part of educational and screening protocols.