PeerView Immunology & Transplantation CME/CNE/CPE Audio Podcast

Go online to PeerView.com/CJR860 to view the activity, download slides and practice aids, and complete the post-test to earn credit. Preventing and managing graft-versus-host disease (GVHD) remains a significant problem in the post–allogeneic hematopoietic stem cell transplant (HCT) setting. Can a wide range of unique treatment modalities, including costimulatory compounds, targeted agents, and engineered cell therapy, challenge long-standing management protocols in this setting? Find out in this activity, based on a recent live symposium, which features an overview of available and emerging therapeutic options for modern GVHD management as a means to extend the benefits of HCT and provide more effective prophylaxis and treatment. Upon completion of this activity, participants should be better able to: Summarize current safety/efficacy evidence supporting the use of novel therapeutics for prophylaxis or treatment of acute or chronic graft-versus-host-disease (GVHD) in the post-transplant setting; Develop management plans with novel and emerging therapeutics for the prophylaxis of GVHD in the post-transplant setting, based on current evidence and practice guidelines; and Integrate novel and emerging therapies into safe, personalized treatment plans for the management of acute or chronic GVHD, including novel combinatorial strategies and/or options for second-line management.

Go online to PeerView.com/WCP860 to view the activity, download slides and practice aids, and complete the post-test to earn credit. Psoriasis is a widely prevalent, chronic, systemic, immune-mediated disease that substantially impairs patients’ physical health, quality of life and work productivity. Nearly one-quarter of people with psoriasis have cases that are considered moderate to severe. Despite the availability of effective systemic therapy, many patients remain undertreated or even untreated and are dissatisfied with current treatments. In this activity, two experts review the rationale for TYK2 inhibition as a novel approach for the treatment of moderate to severe psoriasis. In addition, key information for the first-in-class, oral, selective TYK2 inhibitor will be provided, as well as the key roles that advanced practice clinicians (eg, NPs, PAs) play in the management of patients with psoriasis in an era of expanding oral treatment options. Upon completion of this activity, participants should be better able to: Describe the rationale for targeting the TYK2 kinase as it relates to novel approaches for the treatment of moderate to severe psoriasis; Identify patients with psoriasis who are most likely to benefit from novel oral treatments; Select among established and novel therapies to personalize management plans for patients with psoriasis based on efficacy and safety evidence and guidelines; and Facilitate care coordination and communication with patients and other healthcare team members that fosters a whole patient approach to managing psoriasis.

Go online to PeerView.com/SDA860 to view the activity, download slides and practice aids, and complete the post-test to earn credit. Are you prepared to develop personalized treatment plans for your patients with myelofibrosis (MF) that incorporate the latest therapeutic options, including JAK inhibitors, targeted strategies, and HCT? Find out in this new PeerView CME activity, featuring two experts who will use case-based clinical discussions to illustrate how they manage MF with the individual patient in mind. They will use these cases to discuss eligibility for HCT and the need for pre-HCT therapy based on disease risk factors; use of JAK inhibitor in non-HCT settings; practical dosing and safety management considerations; and the emergence of novel targeted and combinatorial strategies in the MF setting. Watch this informative update on personalized care for patients with MF! Upon completion of this activity, participants should be better able to: Discuss patient- and disease-related features of MF that inform prognosis and guide the selection of JAK inhibitors, other targeted strategies, and HCT; Summarize efficacy and safety data surrounding the use of JAK inhibitors, novel targeted strategies, and innovative combination regimens in MF across the therapeutic continuum; and Develop treatment plans that incorporate JAK inhibitors and other novel therapies to manage MF in HCT and non-HCT settings

Go online to PeerView.com/NEC860 to view the activity, download slides and practice aids, and complete the post-test to earn credit. Although chimeric antigen receptor (CAR-T) cell therapy is primarily administered in the inpatient setting, delivery in the outpatient setting likely represents a more convenient and patient-friendly approach that could expand potentially life-saving treatment access for many patients with hematologic cancers. This “Learning Workshop” activity provides learners with the “tools of the trade” for building an outpatient infrastructure that is capable of expanding patient access to CAR-T therapy. Expert panelists discuss the key data supporting CAR-T therapy in hematologic cancers and provide guidance on principles of outpatient cellular therapy, lessons derived from the outpatient experience with stem cell transplantation, and strategies to overcome barriers to patient selection, adverse events, and adequate staffing. Upon completion of this activity, participants should be better able to: Summarize current evidence supporting the integration of CAR-T constructs into the management of hematologic cancers, including in earlier and later lines of care; Cite the infrastructure and design for an outpatient cellular therapy program and the relevant practical experience from home-based transplantation initiatives; Develop strategies for optimal patient selection, staffing, and management of adverse events in the context of an outpatient cellular therapy program; and Employ tools such as quality metrics, telemedicine, and wearable devices in an outpatient cellular therapy program to ensure successful delivery of CAR-T therapy

Go online to PeerView.com/FNM860 to view the activity, download slides and practice aids, and complete the post-test to earn credit. Find out if you are updated on the latest evidence and management considerations on the use of BCMA antibodies and CAR-T cell therapy for the management of multiple myeloma (MM) in this new PeerView learning CME video recorded at the 2023 Tandem Meetings. Watch the MM experts clarify the most recent practice-changing evidence with BCMA-directed treatments and hear them provide insight on rapidly emerging future applications. Throughout, the experts deliver take-homes on the selection and sequential use of BCMA options, their use in earlier lines of therapy, and management of unique safety considerations. Get informed and see if you are hitting the target when it comes to your patients with MM! Upon completion of this activity, participants should be better able to: Summarize new and emerging evidence with novel BCMA-targeting platforms, including ADCs, bispecifics, and CAR-T cell therapy, across several lines of treatment in MM; Apply evidence-based treatment plans with BCMA-targeting platforms for the sequential management of patients with MM; and Utilize proven tools to address practical aspects and safety considerations associated with the use of novel BCMA-targeted platforms, including dosing, scheduling, adherence, and AE management

Go online to PeerView.com/CUN860 to view the activity, download slides and practice aids, and complete the post-test to earn credit. Are you prepared to apply the “new rules” of management to veno-occlusive disease (VOD)/sinusoidal obstruction syndrome (SOS) for your patients at risk for this hematopoietic stem cell transplantation (HCT) complication? Find out in this PeerView Clinical Consult video recorded at the 2023 Tandem Meetings. Watch as our panelists give the latest guidance on VOD/SOS management, while discussing adult and pediatric case scenarios designed to inform on risk assessment, diagnostic confirmation, severity grading, and treatment. Throughout, the experts will highlight how modern care principles can confirm a diagnosis, determine the presence of organ dysfunction, and prompt the initiation of timely supportive care and pharmacologic treatment. Don’t miss this opportunity to get the latest, most effective approaches to VOD/SOS management and received CME credit! Upon completion of this activity, participants should be better able to: Develop effective strategies for VOD risk assessment and diagnosis, including in the immediate pre- and post-HCT setting; Establish the presence of organ dysfunction in patients with a VOD diagnosis using currently available management tools; and Select appropriate treatment options for adult and pediatric patients with VOD in the post-HCT setting, including supportive and pharmacologic measures.

Go online to PeerView.com/KTZ860 to view the activity, download slides and practice aids, and complete the post-test to earn credit. Are you fully prepared to safely integrate BCMA-targeting options into the care plan for your relapsed/refractory multiple myeloma (MM) patients, including treatment with antibodies, bispecific agents, and CAR-T cell therapy? Find out in this expert-led MasterClass and Case Forum recorded at the Annual Hematology Meeting. Watch our experts as they offer learners guidance on the “road to remission” in MM, and hear how recent advances with BCMA-targeted therapies can directly lead to enhanced outcomes in the most challenging treatment settings. Throughout, the experts also provide case-based guidance on therapy selection with BCMA antibodies and CAR-T therapy, and illustrate how evidence-based practice can optimize delivery of care in pretreated disease. Get on the “road to remission” for your patients, and receive CME/MOC credit today! Upon completion of this activity, participants should be better able to: State the current evidence and rationale that support the treatment roles of novel BCMA-targeting platforms, including antibody-drug conjugates, bispecifics, and CAR-T therapy, in relapsed/refractory disease; Select personalized, evidence-based regimens with novel anti-BCMA options based on patient preference, disease prognosis, and functional status, among others; and Develop strategies for addressing practical aspects of BCMA-targeted therapy in RRMM, including issues related to dosing/scheduling, patient counseling, and unique safety considerations such as cytopenias, infusion-related events, ocular toxicity, and cytokine release syndrome, among others.

Go online to PeerView.com/WQY860 to view the activity, download slides and practice aids, and complete the post-test to earn credit. Autoimmune hemolytic anemia (AIHA) has traditionally been considered the simplest and most scholastic example of antibody-mediated autoimmune disease. However, AIHA has recently been identified as a greatly heterogeneous disease because of several immunological mechanisms involved beyond antibodies, complement, and antibody-dependent cell-mediated cytotoxicity. In addition, AIHA may be associated with conditions where the immunologic mechanisms are unpredictably involved. Given the many conditions, an accurate diagnostic approach to AIHA is fundamental for a comprehensive risk assessment and proper therapy. In this activity, based on a recent live symposium, a panel of expert faculty discusses a sufficient diagnostic workup in any patient with AIHA to help determine the possibility of CAD and the rationale for inhibition of complement C1s as an effective long-term therapy for CAD. In addition, they address how to implement classical complement pathway-targeted therapies into treatment plans for CAD based on efficacy and safety data, patient-specific characteristics, and other potential prescribing considerations. Upon completion of this activity, participants should be better able to: Describe the main clinical characteristics and pathogenic mechanisms of autoimmune hemolytic anemia (AIHA); Perform a sufficient diagnostic workup in any patient with AIHA to establish the subtype, including the possibility of cold agglutinin disease (CAD); Discuss the rationale for inhibition of complement C1s as an effective long-term therapy for CAD, particularly symptoms influenced predominantly by activation of the classical complement pathway (eg, chronic hemolysis, anemia, and fatigue); and Integrate classical complement pathway-targeted therapies into treatment plans for CAD based on efficacy and safety data, patient-specific characteristics, and other potential prescribing considerations

Go online to PeerView.com/VXQ860 to view the activity, download slides and practice aids, and complete the post-test to earn credit. Get the latest on BTK inhibitor strategies in CLL in this PeerView Clinical Consults video recorded at the Annual Hematology Meeting. Once inside, you’ll be able to engage with expert panel discussions designed to provide guidance for using BTK inhibitor therapy in CLL based on longer follow-up data from phase 3 trials and head-to-head safety evidence. Throughout, the experts share and comment on real-world cases that reflect modern, customized therapy selection based on prognostic factors, safety and selectivity differences between available agents, and efficacy in pretreated disease. Don’t miss this opportunity to learn about customizing BTKi therapy from our experts, and get your CME/MOC credit hours! Upon completion of this activity, participants should be better able to: Describe current evidence from pivotal clinical trials, head-to-head comparisons, and practice guidelines on BTK inhibitor efficacy, safety, and selectivity differences, including as single-agent approaches or as part of novel combinations; Select personalized BTK inhibitor therapy for patients with treatment-naïve CLL based on prognostic information, the presence of comorbidities, and safety considerations; Recommend sequential BTK inhibitor options for the management of patients with relapsed/refractory CLL or for individuals who develop therapeutic intolerance; and Develop a management plan for adverse events associated with first- and second-generation BTK inhibitors used to treat CLL

Go online to PeerView.com/BMM860 to view the activity, download slides and practice aids, and complete the post-test to earn credit. Robust clinical evidence has proven that more effective upfront treatment platforms based on novel cytotoxics and targeted agents are now available for acute myeloid leukemia (AML)—including for difficult-to-treat subtypes (eg, secondary AML, mutation-defined disease). These new options have been shown to extend survival and, importantly, to allow more patients to reach hematopoietic stem cell transplant (HCT), a potentially curative treatment. Is a new ‘intensive’ treatment strategy forming in the context of modern AML care? Find out in this activity, based on a recent live symposium, and watch as an expert panel uses case-based conversations linked to the latest evidence on intensive upfront treatments to flesh out diagnostic strategies to capture challenging AML subtypes (including those with secondary AML or mutation-defined disease), determine the eligibility of patients for intensive therapeutic platforms, and select personalized upfront regimens with a goal of achieving robust remissions. Upon completion of this activity, participants should be better able to: Cite the diagnostic, prognostic, and therapeutic implications of baseline factors (eg, age, genetic/molecular features, functional status) for challenging AML subtypes—including secondary AML, mutation-defined disease, and higher-risk disease; Summarize current evidence on novel upfront induction/consolidation regimens for use in diverse AML settings; Recommend evidence-based, personalized upfront treatment platforms for patients with challenging AML subtypes, including those eligible for HCT; and Manage unique safety considerations associated with novel upfront treatment platforms, including innovative cytotoxic and targeted regimens