Dr. Nicole Quinn is the Director of Brand and Scientific Communications at STEMCELL Technologies, where as part of her role, she develops and oversees programs that help scientists keep current with the latest scientific advances and innovations in their field. In this episode, she discusses the upcoming second season of the Lab Coats & Life Podcast, which aims to help scientists thrive by keeping listeners informed about useful soft skills and relevant trends in the scientific community. She talks about her role as a co-host, what she’s learned about podcasting, key takeaways from conversations about science mentorship, and what to expect in Season 2. (38:33)

The Aging Mouse Immune System – Researchers delineated the landscape of cell-type-specific transcriptomic changes associated with normal aging in mouse brains. (3:00)

Neoepitopes for Adoptive T Cell Therapy – Conventional T cell therapy can benefit from targeting tryptophan to phenylalanine neoepitopes. (9:16)

Gut Microbiota and Lung Disease –  A commensal protozoan tunes pulmonary immunity via a gut-operated lung immune network. (20:25)

Lymphocyte Migration – Inflamed lymph nodes switch CCR7 ligand mediating lymphocyte recruitment from CCL21 to CCL19. (28:35)

Image courtesy of Dr. Nicole Quinn

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Dr. Gail Bishop is a Professor of Microbiology and Immunology at the University of Iowa, where her lab studies the molecular mechanisms underlying lymphocyte activation and tolerance.  She talks about TRAF signaling, the NFκB pathway, and effects on B and T lymphocytes. She also discusses her role as Editor-in-Chief of The Journal of Immunology.

Pyroptotic Cell Corpses – Cells assemble filopodia before cell rupture to serve as a posthumous mark for a cell that has died by gasdermin-induced pyroptosis.

Engineering Synthetic T Cell Receptors – T-Switch identifies therapeutic TCR variants with enhanced potency and specificity.

Macrophages in Muscle – Macrophages in muscle spindles express the machinery for synthesizing and releasing glutamate.

Synthetic Suppressor T Cells – Researchers engineered human T cells to make a synthetic receptor that recognized overactive T cells.

Image courtesy of Dr. Gail Bishop

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Dr. Lili Yang is a Professor of Microbiology, Immunology, and Molecular Genetics at the University of California, Los Angeles. Her research centers on deciphering the molecular mechanisms regulating anti-cancer immune responses, exploiting knowledge to develop novel immunotherapies for treating cancer, and translating these new cancer immunotherapies from bench to bedside. She talks about engineering off-the-shelf immunotherapies to fight cancer and generating CAR-NKT cells from hematopoietic stem and progenitor cells. She also discusses the role of serotonin and how SSRIs can affect cancer therapy efficacy.

Preventing Apoptosis – Apoptosis inhibition by NLRP3 activators is due to their effects on mitochondria rather than inflammasome activation.

SARS-CoV-2 Spike Proteins in the Brain – SARS-CoV-2 spike protein persists in the skull-meninges-brain axis in COVID-19 patients.

CAR T to Protect Transplanted Beta Cells – hPSCs and Tregs can be co-engineered to protect hPSC-derived cells from immune rejection upon transplantation.

Endogenous Retrovirus Antibodies – An antibody produced by endogenous retrovirus-reactive B cells recognized glycans of a broad range of enveloped viruses.

Image courtesy of Dr. Lili Yang

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Dr. Rahul Roychoudhuri is a Professor of Cancer Immunology at the University of Cambridge (Department of Pathology) and Director (Non-Clinical) of the CRUK Cambridge Centre Training Programme. His lab studies immunoregulatory mechanisms in inflammation and cancer. He talks about enhancing cell therapy with new payloads and targeting cancer cells during metastasis.

Colonizing the Human Microbiome – Researchers identified a phylogenetically distinct group of microbiome-associated, viroid-like RNAs.

Immune Privilege of the Central Nervous System – Regulatory self-peptides bind to MCH II molecules at the central nervous system border.

Heart Attacks and Sleep – Monocytes are recruited to the brain after myocardial infarction to augment sleep and promote healing.

The Circadian Rhythm in Immune Homeostasis – IL-17-producing γδ T cells rely on the molecular clock to maintain adipose tissue homeostasis.

Image courtesy of Dr. Rahul Roychoudhuri

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Dr. Pascal Meier is a Professor and Group Leader at the Institute of Cancer Research in London, England. His group investigates the complex relationship between cell death, immunity, and tumorigenesis. Particularly, they are focused on the role of cell death and inflammation in adaptation to tissue stress, treatment resistance, and tumour surveillance.

New Potential for Cancer Immunotherapy – Researchers have identified a new type of immune cell called stem-like CD4 T cells that play an important role in anti-tumor immunity.

An Improved Treg Therapy – Human OX40 ligand-specific CAR-Tregs may be a potent cellular therapy to control allo- and autoimmune diseases.

Chronic Inflammation Worsens Heart Failure – Blocking the molecular signals between inflammation-causing immune cells and fibroblasts can prevent fibrosis.

Programmable Bacteria – Scientists have engineered a strain of bacteria to express cytokine IFN-γ within the tumor core.

Image courtesy of  Dr. Pascal Meier

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Dr. Marcelo Hill is the Head of the Laboratory of Immunoregulation and Inflammation at the Institut Pasteur de Montevideo. He is also the Founder and Chief Scientific Officer of ARDAN ImmunoPharma. His research focuses on immune regulation in cancer, and how T cells respond to immunotherapy in melanoma. He talks about improving immunotherapy efficacy by activating the inflammasome, and how he is pushing this research towards the clinic by collaborating with industry and creating a spin-off company.

He is then joined by Drs. Marion Brunck and María Julia Lamberti, who discuss the upcoming meeting of the Latin American and Caribbean Association of Immunology, taking place November 4-8 in Buenos Aires. They discuss the challenges and opportunities in the Latin American immunology community, and how this conference aims to promote collaborations and empower early-career researchers.

Staphylococcus aureus Biofilm – Scientists studied tissue microenvironments in models of S. aureus craniotomy and prosthetic joint infections.

T Helper Cell Differentiation – Researchers found that RAMP3 has a cell-intrinsic role in TH1 cell fate determination.

Probiotic Immunotherapy – Researchers used E. coli to deliver neoepitopes that drive T cell-mediated anticancer immunity.

Microglia in Alzheimer’s Pathology – APOE internalization is regulated by cholesterol metabolism in microglia.

Image courtesy of Dr. Marcelo Hill

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Dr. JoAnne Flynn is a Professor of Microbiology and Molecular Genetics at the University of Pittsburgh and Dr. Stephen Hedrick is Chancellor’s Associates Chair VII Distinguished Professor Emeritus at the University of California, San Diego. They talk about the American Association of Immunologists’ Immunology Explained campaign, which aims to explain the science of the immune system to the general public. They also discuss their efforts to educate legislators about the value of immunology research and promote childhood vaccination.

Postnatal T Cell Development – Spatial multiomics show sex differences in early postnatal T cell development.

Organ-Specific Tissue Residency – Retinoic acid is a fundamental component of the host-environment interaction that directs immunosurveillance in tissues.

A Pan-Sarbecovirus Antibody – Scientists identified an antibody that competes with ACE2 and neutralizes several SARS-CoV-2 variants.

NK Cells in RSV – An altered NK cell immunophenotype is associated with severe RSV disease in young children.

Images courtesy of Drs. JoAnne Flynn and Stephen Hedrick

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Dr. Theresa Alenghat is a Professor in the Immunobiology Division and the Margaret K. Hostetter Chair at Cincinnati Children’s Hospital Medical Center, University of Cincinnati. Her lab investigates mechanisms underlying the host-microbiota relationship, and how this regulation affects intestinal immunity and inflammatory bowel disease.  She discusses how butyrate affects tuft cells in the intestine.

Ancient Cheese – Researchers retrieved DNA from ancient kefir cheese to study how human-microbial interactions contribute to the adaptation of domesticated lactobacilli.

Mitochondrial Movement – Mitochondrial transfer augments CD8+ T cell mitochondria mass and metabolic fitness.

CAR T Atlas – Scientists generated a single-cell atlas of pre-infusion CAR T cells and found that elevated type 2 functionality is associated with remission of leukemia.

NAD+ Reconstitution – A unique immune evasion strategy allows viruses to rebuild molecules depleted by the host’s defense system.

Image courtesy of Dr. Theresa Alenghat

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Dr. Roslyn Kemp is a Professor of Immunology at the University of Otago. Her research focuses on T cells as mediators of anti-tumor immunity and inflammation. She discusses using organoids to model inflammatory bowel disease and collecting immune cell signatures in cancer. She also talks about writing a book to demystify science research and careers.

Extending Responses after HIV Treatment – IL-10 and PD-1 blockade controlled viral rebound of SIV in rhesus macaques during analytical treatment interruption.

Autoreactive T Cells in Lupus – Neoself-antigen presentation by MHC-II plays a crucial role in the pathogenesis of systemic lupus erythematosus.

Bison Bile Salt Hydrolase – Researchers determined the molecular structure of a bile salt hydrolase from the bison microbiome.

How Gender-Affirming Hormone Therapy Affects Immunity – Testosterone in trans men alters a cross-regulation axis involving IFN-I and TNF.

Image courtesy of Dr. Roslyn Kemp

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Dr. Wayne Juang is a Field Application Scientist, Immunology at STEMCELL Technologies. In his current role, he works with researchers to help optimize and troubleshoot their experiments. He discusses his path to industry and his motivation to pursue an MBA.

TNF Mutations and Tuberculosis – Two relatives who lack working copies of the TNF gene experienced recurrent bouts of tuberculosis, but are unaffected by other pathogens.

Fibrin and Clotting in COVID-19 – Fibrin drives inflammation and neuropathology in SARS-CoV-2 infection.

Salt in Tumors – Sodium chloride in enhances the activation state and effector functions of human CD8+ T cells.

Fatal Respiratory Infections – Researchers identified oleoyl-ACP hydrolase as an early driver of several severe respiratory diseases.

Image courtesy of STEMCELL Technologies

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