In this edition of the JDD podcast, Ask the Investigator, host Dr. Adam Friedman of GW School of Medicine and Health Sciences is joined by Albert Einstein College of Medicine Chief of Dermatology Dr. Steven Cohen for a throw back podcast covering his landmark 2016 JDD study entitled "iPLEDGE Weaknesses: Is It Time to Address the Flaws?"which highlights the incomplete and inaccurate monitoring of the iPLEDGE Program . Tune in to hear how this multicenter study identified a high percentage of inaccuracies with iPLEDGE patient monitoring. Have there been any changes since this manuscript hit the presses? How does a master medical dermatologist utilize it to counsel patients on isotretinoin use and side effects, and push the envelope with both on and off label uses. Make sure to pop in on this one!