Long Island and Brooklyn based Pain Physician, David Rosenblum, MD describes prolotherapy and discusses mechanism of action, evidence and protocols.  Also mentioned in this podcast, Prolotherapy protocols, low dose version high dose dextrose prolotherapy, spine prolotherapy, Spine ligaments Intertransverse ligament, Ilolumbar ligament pain and more!

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References Geonhyeong Bae, Suyeon Kim, Sangseok Lee, Woo Yong Lee, Yunhee Lim. Prolotherapy for the patients with chronic musculoskeletal pain: systematic review and meta-analysis Anesth Pain Med 2021;16(1):81-95. Solmaz, İ. & Örsçelik, A. (2022). Approximately Three Years of Prolotherapy Experience of a Traditional and Complementary Medicine Center: An Epidemiologic Study . International Journal of Traditional and Complementary Medicine Research , 3 (2) , 64-70 . DOI: 10.53811/ijtcmr.1040648   Harmon, Dominic, and Vladimir Alexiev. "Sonoanatomy and injection technique of the iliolumbar ligament." Pain Physician 14.5 (2011): 469.   https://clinicaltrials.gov/ct2/show/NCT04680936 David Rosenblum, MD   Sit, R.W.S., Wu, R.W.K., Reeves, K.D. et al. Efficacy of intra-articular hypertonic dextrose prolotherapy versus normal saline for knee osteoarthritis: a protocol for a triple-blinded randomized controlled trial. BMC Complement Altern Med 18, 157 (2018). https://doi.org/10.1186/s12906-018-2226-5