In oncology we are always asking questions about which treatment option is best. And that focus on the next best treatment may prevent us from rethinking some fundamentals of current practice. Three recent studies illustrate this and made me ask:

Do we need a Port or PICC for every testicular cancer patient?

Study: https://doi.org/10.1200/OP.23.00580

Editorial: https://doi.org/10.1200/OP.23.00730

Is vaginal estrogen safe if breast cancer patients?

Study: https://jamanetwork.com/journals/jamaoncology/article-abstract/2811413

Does paclitaxel work differently than we always thought?

Study: https://doi.org/10.1371/journal.pbio.3002339