In the first episode of Rumblings: The CHEST 2025 Podcast, Sandhya Khurana, MD, FCCP, Chair of the Scientific Program Committee for CHEST 2025, and CHEST President John Howington, MD, MBA, FCCP, welcome you to CHEST 2025 and give a glimpse into the first day of the meeting, including the Opening Session (8 am CT, Arie Crown Theater), the Keynote Address from adventurer and cancer survivor Sean Swarner, and the All-Attendee Welcome Reception (5:30 pm, Marriott Marquis, Grand Horizon ABC).