In this podcast episode, Dennis and Pac discuss the use of ketamine in medical settings, particularly in austere environments. They cover topics such as the differences between S-ketamine and R-ketamine, the dosing and administration of ketamine for sedation and analgesia, and its use in hemodynamically unstable patients and refractory seizures. They also touch on the importance of proper training and monitoring when using ketamine, as well as the potential benefits of combining regional anesthesia with IV sedation. Overall, ketamine is seen as a versatile and effective drug for pain management and sedation in various medical scenarios.