Guidelines recommend against red blood cell (RBC) transfusion in hemodynamically stable children without cardiac disease who meet certain criteria. Maureen A. Madden, DNP, RN, CPNP-AC, CCRN, FCCM, is joined by Katherine Steffen, MD, MHS, to discuss the clinical and economic impacts of compliance with RBC transfusion guidelines, as discussed in "The Impact of Restrictive Transfusion Practices on Hemodynamically Stable Critically Ill Children Without Heart Disease: A Secondary Analysis of the Age of Blood in Children in the PICU Trial" published in the February issue of Pediatric Critical Care Medicine (Steffen K et al. Pediatr Crit Care Med. 2023;24:84-92). Dr. Steffen is a clinical associate professor of pediatrics at Stanford University School of Medicine in Palo Alto, California, USA.