Did you know that murder mystery writer Agatha Christie had a background in chemistry? In about half of her stories, the murder is committed using poison—something she was very, very familiar with. She had even trained in apothecaries to mix prescriptions by hand before she became a novelist. Chemist-turned-author Kathryn Harkup wrote about them in her new book, V is for Venom: Agatha Christie’s Chemicals of Death. Harkup talks with Host Flora Lichtman about the science of poisons, why they’re so popular in whodunnits, and how to get away with murder (in fiction writing, of course).

Guest: 
Kathryn Harkup is a former chemist and author of V is for Venom: Agatha Christie’s Chemicals of Death.

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On August 5, Health Secretary Robert F. Kennedy Jr. announced that the Department of Health and Human Services would terminate almost $500 million in mRNA vaccine development grants and contracts, affecting 22 projects. Biologist and mRNA researcher Jeff Coller joins Host Ira Flatow to talk about what this move means for future mRNA research in the US beyond these immediate projects.

Plus, reporter Casey Crownhart joins Ira to discuss the latest in climate news, including flooding in Juneau, Alaska; how Ford is pursuing further electric vehicle manufacturing despite federal roadblocks; and a startup using Earth itself as a giant battery.

Guests:

Dr. Jeff Coller is the Bloomberg Distinguished Professor of RNA Biology and Therapeutics at Johns Hopkins University.
Casey Crownhart is a senior climate reporter for MIT Technology Review in New York, New York.

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If you’ve found yourself scrolling through the breastfeeding world online, you know that people have a lot of strong opinions about breast milk. But what exactly do we know about the biology of it? Does breast milk really adapt to a baby’s needs? Does it confer immunity? How does making breast milk impact the breastfeeder? Joining Host Flora Lichtman to spin through the science of this sophisticated substance are experts Shelley McGuire and Deepshika Ramanan.

Guests: 
Dr. Shelley McGuire is the director of the Margaret Ritchie School of Family and Consumer Sciences at the University of Idaho.
Dr. Deepshika Ramanan is an assistant professor at the Salk Institute for Biological Studies.

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Science journalist Tom Zeller Jr. has suffered from debilitating cluster headaches for three decades. Like other cluster headache sufferers, his episodes would leave him unable to function, and the fear of the next one happening was constant. In a quest to better understand his own condition, Zeller learned that headaches remain a great neurological mystery, with basic mechanisms behind why they happen still unknown. He joins Host Flora Lichtman to talk about his new book, The Headache: The Science of a Most Confounding Affliction – and a Search for Relief.

Guest:
Tom Zeller Jr. is editor in chief of Undark and author of the book The Headache: The Science of a Most Confounding Affliction – and a Search for Relief. He’s based in Montana.

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Last week, astronaut James Lovell died at the age of 97. In April of 1970, he was the commander of the Apollo 13 mission, which launched with three astronauts en route to the moon. While in space, however, the craft encountered a serious problem: an explosion in one of its fuel tanks that severely damaged the craft and disabled its electrical system, prompting the famous phrase, “Houston, we’ve had a problem.” In 1995, on the occasion of the 25th anniversary of the mission, Host Ira Flatow spoke with Lovell about the historic flight and how good luck and ingenuity among the crew and mission controllers on the ground combined to bring the Apollo 13 astronauts safely back to Earth.

Guest:
James Lovell was a NASA astronaut and commander of the Apollo 13 mission.

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Fungal networks in the soil are arguably the basis of much of life on Earth, but they’re understudied and underappreciated in the conservation world. Scientists at the Society for the Protection of Underground Networks (SPUN) are trying to fix that. They just unveiled a global map of mycorrhizal fungal networks, which highlights how widespread they are and how little protection they have. Host Flora Lichtman talks with two of the SPUN mapmakers, Adriana Corrales and Michael Van Nuland, about the importance of fungal networks and why they need more protection.

Guests: Dr. Adriana Corrales is a forest ecologist and scientist with the Society for the Protection of Underground Networks. She’s based in Bogotá, Colombia.
Dr. Michael Van Nuland is an ecologist and scientist with the Society for the Protection of Underground Networks. He’s based in Portland, Oregon.

Transcripts for each episode are available within 1-3 days at sciencefriday.com.

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The mechanisms behind Alzheimer’s disease have eluded scientists for decades. But a new breakthrough points to lithium as a possible explanation—not only does it occur naturally in the brain, but a deficiency causes dementia in mice. This research is one of thousands of projects that have lost funding due to President Trump’s cuts to the National Institutes of Health (NIH). 

Host Ira Flatow speaks with Alzheimer’s researcher Bruce Yankner about this new finding, and then to epidemiologist Katelyn Jetelina and immunologist Elisabeth Marnik about the country’s “quiet engine of science,” the NIH.

Guests: 
Dr. Bruce Yankner is professor of genetics and neurology at Harvard Medical School in Boston, Massachusetts.
Dr. Katelyn Jetelina, epidemiologist and author of the Your Local Epidemiologist newsletter. She’s based in San Diego.
Dr. Elisabeth Marnik is an immunologist and Director of Science Education & Outreach at the MDI Biological Laboratory in Bar Harbor, Maine.

Transcripts for each episode are available within 1-3 days at sciencefriday.com.

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If social media and certain influential podcast hosts are to be believed, cold plunges can do everything from boosting your immune system to reducing inflammation to acting as an antidote for depression. But what does the science say? Joining Host Flora Lichtman to throw at least a few drops of cold water on this science of plunging is biologist François Haman, who studies human performance and cold exposure.

And, with the help of the HBO show “Last Week Tonight,” a minor league baseball team in Pennsylvania rebranded themselves the Erie Moon Mammoths. That comes just a few months after the Utah NHL franchise renamed itself the Utah Mammoth as a nod to that state’s paleontological past. So, why are mammoths back? And do they really have what it takes to be a successful team mascot? Paleontologist Advait Jukar joins Host Flora Lichtman to weigh in.

Guests: 
Dr. François Haman is a biologist at the University of Ottawa who studies how the human body responds to extreme environments.
Dr. Advait Jukar is the assistant Curator of Vertebrate Paleontology at the Florida Museum of Natural History.

Transcripts for each episode are available within 1-3 days at sciencefriday.com.

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Dr. Masao Tomonaga was only 2 years old when the United States bombed his home city of Nagasaki. He survived, and grew up to become a physician for other survivors, known as hibakusha. He also studied hematology, and his research on leukemia and myelodysplastic syndromes was foundational for understanding how radiation affects the body. On the 80th anniversary of the bombings of Hiroshima and Nagasaki, he speaks with Host Ira Flatow about his life’s work, how hibakusha lived with the medical consequences of the bombs, and his message to the world.

Guest: 
Dr. Masao Tomonaga is a survivor of the atomic bombing of Nagasaki and director emeritus of the Japanese Red Cross Nagasaki Atomic Bomb Hospital.

Transcripts for each episode are available within 1-3 days at sciencefriday.com.

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The first complete draft of the human genome was published back in 2003. Since then, researchers have worked both to improve the accuracy of human genetic data, and to expand its diversity, looking at the genetics of people from many different backgrounds. Three genetics experts join Host Ira Flatow to talk about a recent close examination of the genomes of 65 individuals from around the world, and how it may help researchers get a better understanding of genomic functioning and diversity.

Guests:

Dr. Christine Beck is an associate professor of genetics and genome sciences in the University of Connecticut Health Center and the Jackson Laboratory.
Dr. Glennis Logsdon is an assistant professor of genetics and a core member of the Epigenetics Institute at the University of Pennsylvania.
Dr. Adam Philippy is a Senior Investigator in the Center for Genomics and Data Science Research at the National Human Genome Research Institute at the NIH.

Transcripts for each episode are available within 1-3 days at sciencefriday.com.

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