Over the last week, news of “synthetic human embryos” has made headlines around the world. Science in Action is getting to the bottom of the sensational story.

We talk to two of the researchers who have made the embryo models from stem cells in their labs; Professor Magdalena Zernicka-Goetz from the University of Cambridge and California Institute of Technology, and Professor Jacob Hanna from the Weizmann Institute of Science in Israel. They tell us how they made the embryo models, what their aims are, and their own ethical considerations.

The scientific community is excited, but not surprised, by the breaking research. We hear how Dr Andreia Bernardo, group leader at Imperial College London, could use these structures in her future research.

Finally, Director of the Reproductive Sociology Research Group at Cambridge University, Professor Sarah Franklin, and Professor of Law at Stanford University, Hank Greely, tackle the legal and ethical constraints on this kind of work, and why it is important for understanding the health of mothers and babies.

Photo Credit: Magdalena Zernicka-Goetz Lab

Presenter: Roland Pease

As Pacific Ocean temperatures rise, a major El Niño is looming. Experts from the European Centre for Medium range Weather Forecasting, Magdalena Balmaseda and Tim Stockdale, join us to discuss how it is heating up the world and if it could herald in a new period of climate uncertainty.

Last month, Roland stayed up all night to watch the spectacular explosion of supernova 2023ixf. Now, Dr Charlie Kilpatrick, a postdoctoral fellow at Northwestern University, has identified the star that blew up 21 million lightyears away. A similar star in our galaxy, the exceptionally bright Betelgeuse, has been acting strangely. Dr Andrea Dupree, a senior astrophysicist at the Center for Astrophysics, Harvard and Smithsonian, has been trying to figure out what is going on. Is this iconic star about to pop?

And from ageing stars to ageing flies, researchers have published a cell-by-cell map of fruit flies throughout the life of the short lived creatures, showing how they change. Steve Quake, professor of bioengineering and professor of applied physics at Stanford University, tells us what this means for us.

Presenter: Roland Pease

(Image: Illustration of the world map showing areas of rising temperatures. Credit: ClimateReanalyzer.org)

The origin of all complex life has been traced back 1.6 billion years as new molecular fossil records have discovered the fatty stains that our ancient single celled ancestors have left behind. Jochen Brocks, Professor of Geobiology at Australian National University, discusses the significance of these unique biological signatures.

One billion years later, to a mere 462 million years ago, life on Earth was experiencing a boom of new species but we have very few fossil records to understand this era. Now, palaeontologists Dr Joe Botting and Dr Lucy Muir have found the most abundant deposit of soft bodied fossils from this time in a tiny Welsh quarry.

Next, to the relatively recent past, 350,000 years ago, where remains found in a South African cave suggest that an extinct species of human, Homo Naledi, buried their dead. But Mike Petraglia, Professor of Human Evolution and Prehistory at the Max Planck Institute, doubts these claims.

And in the modern day, the fungi which have colonised our soil for millions of years are still helping us clean up the atmosphere. Professor of Plant-Soil Processes at the University of Sheffield, Katie Field, tells us about the astounding amount of carbon captured by the fungus beneath our feet.

Presenter: Roland Pease

(Image: Artist’s imagination of an assemblage of primordial eukaryotic organisms of the ‘Protosterol Biota’ inhabiting a bacterial mat on the ocean floor.

The California Condor has been brought back from the brink of extinction by dedicated conservation efforts over the past 30 years. Now, this critically endangered species is the latest victim of the H5N1 bird flu which is racing round the world. California Condor co-ordinator Ashleigh Blackford and wildlife veterinarian Dr Samantha Gibbs from the US Fish and Wildlife Service discuss their last-ditch efforts to vaccinate the birds against H5N1.

Huge 40,000 km plumes of water ice have been imaged erupting from Saturn’s moon Enceladus. Dr Sara Faggi, a postdoctoral Researcher in the Solar System Division at Nasa Goddard Space Flight Center, dives into this incredible new observation from the James Webb Space Telescope.

Dr Pierre Galand from France’s Observatoire Océanologique de Banyuls has been part of a two-and-a-half-year expedition to sample the microorganisms in coral reefs across the world. His new research shows that this tiny life is much more diverse than previously understood and may be essential to life of the coral reefs. And, much deeper in the Ocean, researchers estimate that there are over 5000 unnamed species in the world’s largest mineral exploration region, the Clarion-Clipperton Zone. Muriel Rabone, data and sample co-ordinator, and Dr Adrian Glover, merit researcher, both from the Natural History Museum in London, talk to Roland about this region of stunning biodiversity and the hope to protect it.

Presenter: Roland Pease

(Photo: An adult and juvenile California condor. Credit: Loi Nguyen)

A star in the nearby Pinwheel Galaxy has exploded spectacularly into a supernova, dubbed SN 2023ixf. It is the brightest in a decade and it has got astronomers around the world into a frenzy. Science in Action hears from both amateur and professional astronomers alike as they scramble to collect exciting new images and data.

Back on the ground, we hear from the Professor of Climate Change and Earth System Science at the University of Exeter, Tim Lenton about his new paper highlighting how rising global temperatures could push human populations from their homes.

Contributors:

Presenter: Roland Pease

(Image: Supernova SN 2023ixf. Credit: Dr Jane Clark and The Cardiff Astronomical Society)

Over the past few weeks, wildfires have scorched over 1,800 square miles of land across North West America and are still going strong. Dr Mike Flannigan, professor at the Department of Renewable Resources at the University of Alberta, talks to Roland about the weather patterns and record-breaking heat causing the devastating flames.

On the other side of the world, in Zambia, Dr Edgar Simulundu has been finding out why some humans attract mosquitoes more than others, and how we can use this to tackle the malaria epidemic.

Also this week, Professor Novel Chegou, lead investigator at Stellenbosch University Immunology Research Group, has been awarded the 2022 Africa Prize for his innovative method for quickly diagnosing tuberculosis. And we visit the Royal Society for a very different reason. Roland checks in on the “Ukraine's Recovery: Rebuilding with Research” conference, and the discussion to use evidence based approaches for rebuilding after war.

Contributors:

Dr Mike Flannigan, Department of Renewable Resources at the University of Alberta

Presenter: Roland Pease

In 2003, an incredible scientific milestone was achieved as the first human genome completed sequencing. For 20 years, this genome has been used as a reference by researchers for comparison to all other DNA sequences. Now, the Human Pangenome Reference Consortium is addressing the lack of genetic diversity starting with 47 new reference genomes. Members of the consortium, Dr Karen Miga, assistant professor, UC Santa Cruz Genomics Institute and Dr Benedict Paten, associate professor, UC Santa Cruz Genomics Institute, join Roland to discuss the first stages of the project.

(Image Illustration of the globe. Credit: Darryl Leja, NHGRI)

India is at the centre of much of the discussion on this week’s episode of Science In Action.

We hear about how a proposal to scrap Darwinian evolution from Indian secondary schools has led to signatures from thousands of scientists. Dr Vineeta Bal, Researcher at the National University of Immunology, is one of the signatories on a petition against the proposed changes. We spoke to her about why she is against them.

Also in India, a new Sars-Cov-2 variant, named XBBX.16 is being studied by epidemiologists in the country. Dr Rajesh Karyakarte, professor of microbiology at BJ Government Medical College, Pune, India, is behind the study.

Further study of the variant has been looked into by Kei Sato, professor of Systems Virology at the University of Tokyo. Kei has been mapping how new variants could cause us problems, ahead of them doing so.

This kind of forward planning is something praised by Paul Bienaisz, Professor of Virology at The Rockefeller university. We talk to him about how vital this kind of work still is, even if many of us have confined the about the SARS-CoV-2 pandemic to memory.

Lastly, we hear from Dr Usama Kadri, Senior Lecturer in Applied Mathematics at Cardiff University who has looked at how we might be able to use a novel bit of technology of underwater technology (called hydrophones), often used for animal conservation, to be able to detect earthquakes in the deep sea.

Presenter/producer: Roland Pease

Khartoum’s National Public Health Laboratory has been caught up in the ongoing conflict in Sudan. Dr Maysoon Dahab and Dr Ayman Ahmed explain the situation and why health labs are often targeted in conflicts.

Virus hunters have used artificial intelligence to discover more than 180,000 new viruses. Professor Eddie Holmes and Dr Mang Shi tell Roland how AI is completely transforming the field of viral discovery.

Experts have forecasted a return to El Niño conditions later this year, which could bring with it extreme weather events. Dr Emily Becker explains how the predictions are made and the global impact of a strong El Niño.

And from future to historical weather – Roland talks to Professor Ed Hawkins about the powerful Storm Ulysses of 1903, and how it can help us better understand storms today.

Presenter: Roland Pease

The pandemic showed Africa at the back of the global queue when it came to vaccines. That should never happen again if plans being debated in Cape Town this week go ahead. Roland talks to Seanette Wilson of South Africa's Biovac.

Also in the programme: life finds a way on plastic floating in the ocean; Greenland rock dust as a global fertiliser; and designing proteins from scratch.

Image Credit: Robert Bonet/NurPhoto via Getty Images

Presenter: Roland Pease