Science (Video)

Cerebral organoids, also known as mini-brains, are tridimensional self-organized structures derived from stem cells that resemble the early stages of the human embryonic brain. This new tool allows researchers to explore fundamental neurodevelopmental steps otherwise inaccessible in utero experimentally. Alysson Muotri, UC San Diego Stem Cell Program, explains how mini brains are generated in his lab and how this strategy can create novel therapeutical insights on neurogenetic disorders, such as autism. He also describes the use of mini-brains to explore the uniqueness of the human brain compared to other extinct species, such as the Neanderthals. Limitations and ethical concerns surrounding this exciting technology are also discussed. Series: "Exploring Ethics" [Humanities] [Science] [Show ID: 33715]

Organoides cerebrais, também conhecidos como minicérebros, são estruturas auto-organizadas tridimensionais derivadas de células-tronco que se assemelham aos estágios iniciais do cérebro embrionário humano. Esta nova ferramenta permite que pesquisadores explorem etapas fundamentais do neurodesenvolvimento que, experimentalmente, são inacessíveis no útero. Alysson Muotri, do Programa de Células-tronco da UC San Diego (Universidade da Califórnia San Diego), explica como minicérebros são gerados em seu laboratório e como esta estratégia pode criar novos insights terapêuticos sobre distúrbios neurogenéticos, como o autismo. Ele também descreve o uso de minicérebros para explorar a singularidade do cérebro humano em comparação com outras espécies extintas, como os Neandertais. As limitações e as preocupações éticas que cercam esta tecnologia fascinante também são discutidas.

Series: "O Canal de Células-Tronco" [Humanities] [Science] [Spanish Language] [Show ID: 34642]

Los organoides cerebrales, también conocidos como minicerebros, son estructuras tridimensionales autoorganizadas derivadas de células madre que se asemejan a las primeras etapas del cerebro embrionario humano. Esta nueva herramienta permite a los investigadores explorar los pasos fundamentales del desarrollo neurológico inaccesibles en el útero de forma experimental. Alysson Muotri, Programa de Células Madre de la UC San Diego, explica cómo se generan los minicerebros en su laboratorio y cómo esta estrategia puede crear nuevas perspectivas terapéuticas sobre los trastornos neurogenéticos, como el autismo. También describe el uso de minicerebros para explorar la singularidad del cerebro humano en comparación con otras especies extintas, como los neandertales. También se discuten las limitaciones y las preocupaciones éticas que rodean a esta emocionante tecnología.

Series: "El Canal de Células Madre" [Humanities] [Science] [Spanish Language] [Show ID: 34643]

Scripps Research's Stefano Forli shares about his work using computational tools to screen large libraries of compounds using methods such as high throughput virtual screening (HTVS) or designing focused virtual libraries based on specific synthetic pathways to identify molecules that can act as biological probes and novel therapeutic agents. Series: "Saturday Science at Scripps Research " [Science] [Show ID: 34071]

What technology risks are faced by people who experience intimate partner violence? How is the security community failing them, and what questions might we need to ask to make progress on social and technical interventions? UC San Diego CSE Alumnus Thomas Ristenpart discusses computer security with a focus on digital privacy and safety in intimate partner violence. He is a member of the Computer Science department at Cornell University. Series: "Computer Science Channel" [Science] [Show ID: 34588]

Darold Treffert shares the fascinating story of Leslie Lemke, a musical savant, to provide a look at the characteristics of savantism. Series: "CARTA - Center for Academic Research and Training in Anthropogeny" [Science] [Show ID: 32447]

Orca, J-50, is loosing weight and researchers at UC Davis Veterinary School of Medicine and SeaDoc Society are exploring innovative ways to study what might be wrong with her. Series: "UCTV Prime" [Science] [Show ID: 34578]

April Pyle, Department of Microbiology, Immunology and Molecular Genetics at UCLA, uses multi-disciplinary approaches to study human pluripotent stem cell biology and differentiation of these cells for use in regenerative medicine. She studies both basic aspects of stem cell biology as well as more translational aspects of human pluripotent stem cell differentiation towards skeletal muscle for use in therapeutic approaches for patients with muscular dystrophy.

Series: "Women in Science" [Health and Medicine] [Science] [Education] [Professional Medical Education] [Show ID: 34442]

Sometimes the most useful tools are unexpected and this might be said of Professor Sarah Stewart’s Shock Compression laboratory, where huge cannons are fired (indoors) to study the early history of our Solar System. Series: "UCTV Prime" [Science] [Show ID: 34579]

Veterinarians at UC Davis and the Sacramento Zoo perform surgery on Coconut's eyelids to remove hair that is causing irritation Series: "UCTV Prime" [Science] [Show ID: 34581]