Dealing with a serious or chronic health condition is hard enough — but what happens when that condition comes with moral judgment? That’s the case for millions of people around the world. From obesity to lung cancer, sexually transmitted diseases to mental illness, stigmatized conditions are shrouded in shame and blame that can not only hinder treatment — but ruin lives.

On this episode, we explore stigmatized health conditions — how they earn their reputations, affect the lives of patients, and complicate efforts to treat them. We hear about the flawed effort to track down the origin of the HIV epidemic in the U.S. that inadvertently introduced a new term into our language. We explore what researchers say is behind the “blame and shame” game in public health, and we find out why a man diagnosed with antisocial personality disorder says his condition isn’t always as scary as people think.

Also heard on this week’s episode: