Shrines dedicated in honor of St. Anne are among the oldest Catholic establishments in the U.S. St Anne de Detroit, for instance, is the second-oldest parish in the United States, while the shrine on Isle la Motte, Vermont, was part of a French fort protecting the southern approaches to Montreal. Some shrines have dramatic stories, like the National Shrine of St. Anne in Scranton, Pennsylvania which nearly collapsed due to mining activity in the hill beneath it. Most have a relic of St. Anne, the grandmother of Jesus. The Shrine of St. Anne in Fall River, Massachusetts was built to rival the great shrine of St. Anne de Beaupre in Quebec, but demographic changes brought that awe-inspiring structure nearly to the point of demolition. These shrines often arose where French and French Canadians settled, as the French have historically had a deep devotion to the  mother of Mary and grandmother of Jesus. 

Image credits: St. Anne de Detroit, creative commons license, Polonia90; St. Anne's Church and Parish Complex, Fall River, Massachusetts, creative commons license, Kenneth C. Zirkel