Simplavida: Simplified Longevity

Paul and Howard talk about healthy aging, from cell death, to diet, to centenarians, and exercise in-between. Financial geek that he is, Paul sneaks in a little riff about pension fraud too. There is a fairly crap transcript here.

Topics:

• Healthspan vs lifespan, squaring the curve
• Cellular housekeeping and whether it can be catalyzed
• Diets -- good, bad, and simple
• What we can learn from centenarian studies, and where are their flaws

Readings and Books Mentioned:

• Muscle mass and longevity
• Squaring off the lifespan curve 
• Metabolic health and our muscles, tendons, and joints
• Supercentenarian and remarkable age records exhibit patterns indicative of clerical errors and pension fraud

Bios:

Paul Kedrosky is a frequently injured athlete who, when he isn't rehabbing, is also a venture investor. Howard Luks is a top sports orthopedic surgeon.

Music & Disclaimers:

• Crossing the Chasm by Kevin MacLeod
   Link: https://incompetech.filmmusic.io/song/3562-crossing-the-chasm
   License: http://creativecommons.org/licenses/by/4.0/
• Marty Gots A Plan by Kevin MacLeod
   Link: https://incompetech.filmmusic.io/song/4992-marty-gots-a-plan
   License: http://creativecommons.org/licenses/by/4.0/

Disclaimers apply and can be heard at the end of the episode.

This is only an excerpt. To listen to the entire episode, as well as see show notes and full transcripts, subscribe at simplavida.com.

Paul and Howard talk about air, exercise, lung function, and breathing in an age of wildfires and coronavirus. There is a fairly crap transcript here.

Topics:

• Viruses and exercise
• A primer on lung function during exercise
• How much outdoor exercise is safe when air quality is lousy
• Best ways to limit your pollutant exposure

Related Readings:

• Can air pollution negate the health benefits of cycling and walking?
• Air Pollution–Mediated Susceptibility to Inflammation and Insulin Resistance: Influence of CCR2 Pathways in Mice
• Should You Stop Exercising During Wildfire Season?
• Ambient Particulate Air Pollution and Daily Mortality in 652 Cities

Companies/Products Mentioned:

• Plume Labs
• IQAir
• Blue Air

Bios:

Paul Kedrosky is a frequently injured athlete who, when he isn't rehabbing, is also a venture investor. Howard Luks is a top sports orthopedic surgeon.

Music & Disclaimers:

• Crossing the Chasm by Kevin MacLeod
   Link: https://incompetech.filmmusic.io/song/3562-crossing-the-chasm
   License: http://creativecommons.org/licenses/by/4.0/
• Marty Gots A Plan by Kevin MacLeod
   Link: https://incompetech.filmmusic.io/song/4992-marty-gots-a-plan
   License: http://creativecommons.org/licenses/by/4.0/

Disclaimers apply and can be heard at the end of the episode.

This is only an excerpt. To listen to the entire episode, as well as see show notes and full transcripts, subscribe at simplavida.com.

We got lots of questions on our recent episode about air, exercise, and wildfires, so here is a short, deeper dive into the topic. We gave Howard the episode off, so I have a special guest, Christopher T. Migliaccio, a Research Assistant Professor in Immunology at the University of Montana. His main research interest is how environmental particulates in the respiratory system affect pulmonary immunology, and he is doing ongoing work on the effect of wildfires on pulmonary function.  There is a Fairly Crap Transcript™ here. 

Topics:

• Lung immunology and the role of macrophages
• The medium-term health effects of multi-day exposure to smoke, based on a cohort study of Montana's 2017 wildfires
• Consequences of particulate for lung infections, from influenza to coronavirus 

Related Links

• Christopher T. Migliaccio main page
• Research profile
• Alveolar Macrophages in Lung Inflammation and Resolution
• Montana 2017 wildfires

Credits

• Crossing the Chasm Kevin MacLeod Licensed under Creative Commons: By Attribution 3.0 http://creativecommons.org/licenses/by/3.0/
• Wholesome by Kevin MacLeod Link: https://incompetech.filmmusic.io/song/5050-wholesome License: http://creativecommons.org/licenses/by/4.0/

Bios:

Paul Kedrosky is a frequently injured athlete who, when he isn't rehabbing, is also a venture investor. Howard Luks is a top sports orthopedic surgeon.

Music & Disclaimers:

• Crossing the Chasm by Kevin MacLeod
   Link: https://incompetech.filmmusic.io/song/3562-crossing-the-chasm
   License: http://creativecommons.org/licenses/by/4.0/
• Marty Gots A Plan by Kevin MacLeod
   Link: https://incompetech.filmmusic.io/song/4992-marty-gots-a-plan
   License: http://creativecommons.org/licenses/by/4.0/

Disclaimers apply and can be heard at the end of the episode.

This is only an excerpt. To listen to the entire episode, as well as see show notes and full transcripts, subscribe at simplavida.com.

Paul and Howard talk about rotator cuffs, those four muscles around your shoulder that often go awry and sometimes really hurt. There is a Fairly Crap Transcript™ here.

Topics:

• What are rotator cuffs anyway? 
  • Tossing, tools, and trees: the evolutionary history of shoulders 
  • What happens if part of your rotator cuff goes, you know, missing?
  • Pretty much everyone over 45 has rotator cuff problems. Most don't notice. 
  • The future of fixing -- and/or not fixing -- rotator cuff problems

Related Readings:

• Shoulder MRI Findings in People with NO Shoulder Pain: Are Some Tears “Normal”
• Calcific Tendonitis — What is it?
• Fossil hominin shoulders support an African ape-like last common ancestor of humans and chimpanzees

Bios:

Paul Kedrosky is a frequently injured athlete who, when he isn't rehabbing, is also a venture investor. Howard Luks is a top sports orthopedic surgeon.

Music & Disclaimers:

• Crossing the Chasm by Kevin MacLeod
   Link: https://incompetech.filmmusic.io/song/3562-crossing-the-chasm
   License: http://creativecommons.org/licenses/by/4.0/
• Marty Gots A Plan by Kevin MacLeod
   Link: https://incompetech.filmmusic.io/song/4992-marty-gots-a-plan
   License: http://creativecommons.org/licenses/by/4.0/

Disclaimers apply and can be heard at the end of the episode.

This is only an excerpt. To listen to the entire episode, as well as see show notes and full transcripts, subscribe at simplavida.com.

Paul and Howard talk about surgical anesthesia with a special guest: Jon Bauman, Chief of Anesthesiology at St. John's Riverside Hospital in Westchester, New York.  There is a Fairly Crap Transcript™ here.

Topics:

• What is anesthesia? Are you asleep? Where does your brain go? 
• What do anesthesiologists do when patients are out? 
• Local, regional, and general anesthesia
• The future of anesthesia, both in terms of technology and anesthesiologist careers

Related Readings:

• The Butchering Art, by Lindsey Fitzharris 
• A history of anesthesiology, Wood Library-Museum of Anesthesiology

Bios:

Paul Kedrosky is a frequently injured athlete who, when he isn't rehabbing, is also a venture investor. Howard Luks is a top sports orthopedic surgeon.

Music & Disclaimers:

• Crossing the Chasm by Kevin MacLeod
   Link: https://incompetech.filmmusic.io/song/3562-crossing-the-chasm
   License: http://creativecommons.org/licenses/by/4.0/
• Marty Gots A Plan by Kevin MacLeod
   Link: https://incompetech.filmmusic.io/song/4992-marty-gots-a-plan
   License: http://creativecommons.org/licenses/by/4.0/

Disclaimers apply and can be heard at the end of the episode.

This is only an excerpt. To listen to the entire episode, as well as see show notes and full transcripts, subscribe at simplavida.com.

Paul and Howard talk about shoes and their consequences. There is a Fairly Crap Transcript™ here.

Topics:

• Why do we wear shoes? 
• The evolutionary history of the foot
• The anatomic consequences of shoe wear
• Mistakes people make buying athletic shoes
• The explosion is athletic shoe varieties, from minimalist shoes, to maximalist shoes, and everything in-between
• Common shoe-related foot injuries

Related Readings:

• Born to Run
• Daniel Lieberman's Skeletal Biology lab
• A history of the running shoe
• Kiss, God of Thunder

Bios:

Paul Kedrosky is a frequently injured athlete who, when he isn't rehabbing, is also a venture investor. Howard Luks is a top sports orthopedic surgeon.

Music & Disclaimers:

• Crossing the Chasm by Kevin MacLeod
   Link: https://incompetech.filmmusic.io/song/3562-crossing-the-chasm
   License: http://creativecommons.org/licenses/by/4.0/
• Marty Gots A Plan by Kevin MacLeod
   Link: https://incompetech.filmmusic.io/song/4992-marty-gots-a-plan
   License: http://creativecommons.org/licenses/by/4.0/

Disclaimers apply and can be heard at the end of the episode.

This is only an excerpt. To listen to the entire episode, as well as see show notes and full transcripts, subscribe at simplavida.com.

Paul and Howard have a special guest, the amazing Dr. Inigo San Milan from the School of Medicine at the University of Colorado, one of the top researchers in the world on this topic. We talk about all aspects of mitochondrial health, from what that means, to what we can do about it, to how mitochondrial health differs between us and top athletes. There is a Fairly Crap Transcript™ here.

Topics:

• What are mitochondria and what do they do
• Mitochondrial health for longevity and for performance 
• How top athletes differ from you and me in terms of mitochondrial health
• The merits of Zone 2 training 
• Dr. San Milan's role as a fitness coach for 2020 Tour de France winner Tadej Pogačar

Related Readings:

• Metabolomics of Endurance Capacity in World Tour Professional Cyclists
• Assessment of Metabolic Flexibility by Means of Measuring Blood Lactate, Fat, and Carbohydrate Oxidation Responses to Exercise in Professional Endurance Athletes and Less-Fit Individuals
• Why do our cell's power plants have their own DNA?
• Introduction to cellular respiration

Bios:

Paul Kedrosky is a frequently injured athlete who, when he isn't rehabbing, is also a venture investor. Howard Luks is a top sports orthopedic surgeon.

Music & Disclaimers:

• Crossing the Chasm by Kevin MacLeod
   Link: https://incompetech.filmmusic.io/song/3562-crossing-the-chasm
   License: http://creativecommons.org/licenses/by/4.0/
• Marty Gots A Plan by Kevin MacLeod
   Link: https://incompetech.filmmusic.io/song/4992-marty-gots-a-plan
   License: http://creativecommons.org/licenses/by/4.0/

Disclaimers apply and can be heard at the end of the episode.

This is only an excerpt. To listen to the entire episode, as well as see show notes and full transcripts, subscribe at simplavida.com.

Paul and Howard talk about the relationship between muscle mass, strength, and longevity. There is a Fairly Crap Transcript™ here.

Topics:

• Why muscle mass is important, and not just for bodybuilders
• The loss of muscle with age, the technical term for which is sarcopenia
• The many consequences of loss of muscle tone are many, from strength, to metabolic syndrome, to Alzheimer's 
• How you can preserve muscle tone without going to a gym, and do it as efficiently as possible

Related Readings:

• Muscle mass, strength, and longevity
• Changes in Body Composition Measures With Risk of Heart Failure and Myocardial Infarction in Type 2 Diabetes
• Stronger legs: Six reasons you should start squatting today 

Bios:

Paul Kedrosky is a frequently injured athlete who, when he isn't rehabbing, is also a venture investor. Howard Luks is a top sports orthopedic surgeon.

Music & Disclaimers:

• Crossing the Chasm by Kevin MacLeod
   Link: https://incompetech.filmmusic.io/song/3562-crossing-the-chasm
   License: http://creativecommons.org/licenses/by/4.0/
• Marty Gots A Plan by Kevin MacLeod
   Link: https://incompetech.filmmusic.io/song/4992-marty-gots-a-plan
   License: http://creativecommons.org/licenses/by/4.0/

Disclaimers apply and can be heard at the end of the episode.

This is only an excerpt. To listen to the entire episode, as well as see show notes and full transcripts, subscribe at simplavida.com.

Paul and Howard take listener questions about strength, longevity, and fitness. There is a Fairly Crap Transcript™ here.

Topics:

• How to stay motivated
• What being fit means
• How to sneak in enough activity

Related Readings:

• Muscle mass, strength, and longevity
• Which  Comes First, Cardio or Weights

Bios:

Paul Kedrosky is a frequently injured athlete who, when he isn't rehabbing, is also a venture investor. Howard Luks is a top sports orthopedic surgeon.

Music & Disclaimers:

• Crossing the Chasm by Kevin MacLeod
   Link: https://incompetech.filmmusic.io/song/3562-crossing-the-chasm
   License: http://creativecommons.org/licenses/by/4.0/
• Marty Gots A Plan by Kevin MacLeod
   Link: https://incompetech.filmmusic.io/song/4992-marty-gots-a-plan
   License: http://creativecommons.org/licenses/by/4.0/

Disclaimers apply and can be heard at the end of the episode.

This is only an excerpt. To listen to the entire episode, as well as see show notes and full transcripts, subscribe at simplavida.com.

In the first of a multi-part series, Paul and Howard talk about metabolic syndrome, from its rise, to its prevalance, to its causes, and its consequences. There is a Fairly Crap Transcript™ here.

Topics:

• What is metabolic syndrome?
• How is it diagnosed?
• The causes of metabolic syndrome
• The rise to prevalence of metabolic syndrome

Related Readings:

• How diet affects our metabolic health
• Metabolic syndrome
• LDL and ApoB Exposure and the evolution of heart disease 
• 10 Techniques To Help You Thrive With Knee Arthritis

Bios:

Paul Kedrosky is a frequently injured athlete who, when he isn't rehabbing, is also a venture investor. Howard Luks is a top sports orthopedic surgeon.

Music & Disclaimers:

• Crossing the Chasm by Kevin MacLeod
   Link: https://incompetech.filmmusic.io/song/3562-crossing-the-chasm
   License: http://creativecommons.org/licenses/by/4.0/
• Marty Gots A Plan by Kevin MacLeod
   Link: https://incompetech.filmmusic.io/song/4992-marty-gots-a-plan
   License: http://creativecommons.org/licenses/by/4.0/

Disclaimers apply and can be heard at the end of the episode.

This is only an excerpt. To listen to the entire episode, as well as see show notes and full transcripts, subscribe at simplavida.com.