Simplavida: Simplified Longevity

Simplavida: Simplified Longevity

By Paul Kedrosky and Howard LuksScienceHealth & FitnessLife Sciences
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Simplavida: Simplified Longevity episodes

  • Coronavirus and Fitness: One Year Later

    Paul and Howard talk about personal fitness and mental health, one year after coronavirus lockdowns began. There is a Fairly Crap Transcript™ here.

    Topics:

    • Assessment through quick condition tests
    • The importance of having fitness objectives
    • What have we learned about injuries and therapies because of pandemic
    • Mental health, the other epidemic
    • Related Readings:

      • Niall Moyna's minimum fitness test
      • Bios:

        Paul Kedrosky is a frequently injured athlete who, when he isn't rehabbing, is also a venture investor. Howard Luks is a top sports orthopedic surgeon.

        Music & Disclaimers:

        • Crossing the Chasm by Kevin MacLeod Link: https://incompetech.filmmusic.io/song/3562-crossing-the-chasm License: http://creativecommons.org/licenses/by/4.0/
        • Marty Gots A Plan by Kevin MacLeod Link: https://incompetech.filmmusic.io/song/4992-marty-gots-a-plan License: http://creativecommons.org/licenses/by/4.0/
        • Disclaimers apply and can be heard at the end of the episode.

          35 min
        • Ep 20: AMA on Strength, Longevity and Fitness

          Paul and Howard take listener questions about strength, longevity, and fitness. There is a Fairly Crap Transcript™ here.

          Topics:

          • How to stay motivated
          • What being fit means
          • How to sneak in enough activity
          • Related Readings:

            • Muscle mass, strength, and longevity
            • Which  Comes First, Cardio or Weights
            • Bios:

              Paul Kedrosky is a frequently injured athlete who, when he isn't rehabbing, is also a venture investor. Howard Luks is a top sports orthopedic surgeon.

              Music & Disclaimers:

              • Crossing the Chasm by Kevin MacLeod Link: https://incompetech.filmmusic.io/song/3562-crossing-the-chasm License: http://creativecommons.org/licenses/by/4.0/
              • Disclaimers apply and can be heard at the end of the episode.

                31 min
              • Muscle Mass, Strength, and Longevity

                Paul and Howard talk about the relationship between muscle mass, strength, and longevity. There is a Fairly Crap Transcript™ here.

                Topics:

                • Why muscle mass is important, and not just for bodybuilders
                • The loss of muscle with age, the technical term for which is sarcopenia
                • The many consequences of loss of muscle tone are many, from strength, to metabolic syndrome, to Alzheimer's 
                • How you can preserve muscle tone without going to a gym, and do it as efficiently as possible
                • Related Readings:

                  • Muscle mass, strength, and longevity
                  • Changes in Body Composition Measures With Risk of Heart Failure and Myocardial Infarction in Type 2 Diabetes
                  • Stronger legs: Six reasons you should start squatting today 
                  • Bios:

                    Paul Kedrosky is a frequently injured athlete who, when he isn't rehabbing, is also a venture investor. Howard Luks is a top sports orthopedic surgeon.

                    Music & Disclaimers:

                    • Crossing the Chasm by Kevin MacLeod Link: https://incompetech.filmmusic.io/song/3562-crossing-the-chasm License: http://creativecommons.org/licenses/by/4.0/
                    • Marty Gots A Plan by Kevin MacLeod Link: https://incompetech.filmmusic.io/song/4992-marty-gots-a-plan License: http://creativecommons.org/licenses/by/4.0/
                    • Disclaimers apply and can be heard at the end of the episode.

                      35 min
                    • Mitochondrial Health: The Path to Longevity and Performance

                      Paul and Howard have a special guest, the amazing Dr. Inigo San Milan from the School of Medicine at the University of Colorado, one of the top researchers in the world on this topic. We talk about all aspects of mitochondrial health, from what that means, to what we can do about it, to how mitochondrial health differs between us and top athletes. There is a Fairly Crap Transcript™ here.

                      Topics:

                      • What are mitochondria and what do they do
                      • Mitochondrial health for longevity and for performance 
                      • How top athletes differ from you and me in terms of mitochondrial health
                      • The merits of Zone 2 training 
                      • Dr. San Milan's role as a fitness coach for 2020 Tour de France winner Tadej Pogačar
                      • Related Readings:

                        • Metabolomics of Endurance Capacity in World Tour Professional Cyclists
                        • Assessment of Metabolic Flexibility by Means of Measuring Blood Lactate, Fat, and Carbohydrate Oxidation Responses to Exercise in Professional Endurance Athletes and Less-Fit Individuals
                        • Why do our cell's power plants have their own DNA?
                        • Introduction to cellular respiration
                        • Bios:

                          Paul Kedrosky is a frequently injured athlete who, when he isn't rehabbing, is also a venture investor. Howard Luks is a top sports orthopedic surgeon.

                          Music & Disclaimers:

                          • Crossing the Chasm by Kevin MacLeod Link: https://incompetech.filmmusic.io/song/3562-crossing-the-chasm License: http://creativecommons.org/licenses/by/4.0/
                          • Marty Gots A Plan by Kevin MacLeod Link: https://incompetech.filmmusic.io/song/4992-marty-gots-a-plan License: http://creativecommons.org/licenses/by/4.0/
                          • Disclaimers apply and can be heard at the end of the episode.

                            35 min
                          • Athletic Shoes: Their History, Benefits, and Consequences

                            Paul and Howard talk about shoes and their consequences..  There is a Fairly Crap Transcript™ here.

                            Topics:

                            • Why do we wear shoes? 
                            • The evolutionary history of the foot
                            • The anatomic consequences of shoe wear
                            • Mistakes people make buying athletic shoes
                            • The explosion is athletic shoe varieties, from minimalist shoes, to maximalist shoes, and everything in-between
                            • Common shoe-related foot injuries
                            • Related Readings:

                              • Born to Run
                              • Daniel Lieberman's Skeletal Biology lab
                              • A history of the running shoe
                              • Kiss, God of Thunder
                              • Bios:

                                Paul Kedrosky is a frequently injured athlete who, when he isn't rehabbing, is also a venture investor. Howard Luks is a top sports orthopedic surgeon.

                                Music & Disclaimers:

                                • Crossing the Chasm by Kevin MacLeod Link: https://incompetech.filmmusic.io/song/3562-crossing-the-chasm License: http://creativecommons.org/licenses/by/4.0/
                                • Marty Gots A Plan by Kevin MacLeod Link: https://incompetech.filmmusic.io/song/4992-marty-gots-a-plan License: http://creativecommons.org/licenses/by/4.0/
                                • Disclaimers apply and can be heard at the end of the episode.

                                  33 min
                                • Ep 16: Inside the Black Box of Anesthesia: Why We Do It, How It's Changing, and What the Future Looks Like

                                  Paul and Howard talk about surgical anesthesia with a special guest: Jon Bauman, Chief of Anesthesiology at St. John's Riverside Hospital in Westchester, New York.  There is a Fairly Crap Transcript™ here.

                                  Topics:

                                  • What is anesthesia? Are you asleep? Where does your brain go? 
                                  • What do anesthesiologists do when patients are out? 
                                  • Local, regional, and general anesthesia
                                  • The future of anesthesia, both in terms of technology and anesthesiologist careers
                                  • Related Readings:

                                    • The Butchering Art, by Lindsey Fitzharris 
                                    • A history of anesthesiology, Wood Library-Museum of Anesthesiology
                                    • Bios:

                                      Paul Kedrosky is a frequently injured athlete who, when he isn't rehabbing, is also a venture investor. Howard Luks is a top sports orthopedic surgeon.

                                      Music & Disclaimers:

                                      • Crossing the Chasm by Kevin MacLeod
                                      • Link: https://incompetech.filmmusic.io/song/3562-crossing-the-chasm
                                        License: http://creativecommons.org/licenses/by/4.0/
                                      • Marty Gots A Plan by Kevin MacLeod
                                      • Link: https://incompetech.filmmusic.io/song/4992-marty-gots-a-plan
                                        License: http://creativecommons.org/licenses/by/4.0/

                                        Disclaimers apply and can be heard at the end of the episode.

                                        34 min
                                      • Rotator Cuffs: Why They Go Awry, and What You Should Do About It. Or Not.

                                        Paul and Howard talk about rotator cuffs, those four muscles around your shoulder that often go awry and sometimes really hurt. There is a Fairly Crap Transcript™ here.

                                        Topics:

                                        • What are rotator cuffs anyway?
                                          • Tossing, tools, and trees: the evolutionary history of shoulders 
                                          • What happens if part of your rotator cuff goes, you know, missing?
                                          • Pretty much everyone over 45 has rotator cuff problems. Most don't notice. 
                                          • The future of fixing -- and/or not fixing -- rotator cuff problems
                                          • Related Readings:

                                            • Shoulder MRI Findings in People with NO Shoulder Pain: Are Some Tears “Normal”
                                            • Calcific Tendonitis — What is it?
                                            • Fossil hominin shoulders support an African ape-like last common ancestor of humans and chimpanzees
                                            • Bios:

                                              Paul Kedrosky is a frequently injured athlete who, when he isn't rehabbing, is also a venture investor. Howard Luks is a top sports orthopedic surgeon.

                                              Music & Disclaimers:

                                              • Crossing the Chasm, Kevin MacLeod. Licensed under Creative Commons: By Attribution 3.0 http://creativecommons.org/licenses/by/3.0
                                              • Disclaimers apply and can be heard at the end of the episode.

                                                33 min
                                              • Episode 14 (A Brief Audio Footnote): A Deeper Dive Into Pulmonary Function and WIldfires

                                                We got lots of questions on our recent episode about air, exercise, and wildfires, so here is a short, deeper dive into the topic. We gave Howard the episode off, so I have a special guest, Christopher T. Migliaccio, a Research Assistant Professor in Immunology at the University of Montana. His main research interest is how environmental particulates in the respiratory system affect pulmonary immunology, and he is doing ongoing work on the effect of wildfires on pulmonary function.  There is a Fairly Crap Transcript™ here. 

                                                Topics Covered:

                                                • Lung immunology and the role of macrophages
                                                • The medium-term health effects of multi-day exposure to smoke, based on a cohort study of Montana's 2017 wildfires
                                                • Consequences of particulate for lung infections, from influenza to coronavirus 
                                                • Related Links

                                                  • Christopher T. Migliaccio main page
                                                  • Research profile
                                                  • Alveolar Macrophages in Lung Inflammation and Resolution
                                                  • Montana 2017 wildfires
                                                  • Credits

                                                    • Crossing the Chasm Kevin MacLeod Licensed under Creative Commons: By Attribution 3.0 http://creativecommons.org/licenses/by/3.0/
                                                    • Wholesome by Kevin MacLeod Link: https://incompetech.filmmusic.io/song/5050-wholesome License: http://creativecommons.org/licenses/by/4.0/
                                                    • 11 min
                                                    • Air & Exercise: Breathing in an Age of Wildfires and Coronavirus

                                                      Paul and Howard talk about air, exercise, lung function, and breathing in an age of wildfires and coronavirus. There is a fairly crap transcript here.

                                                      Topics:

                                                      • Viruses and exercise
                                                      • A primer on lung function during exercise
                                                      • How much outdoor exercise is safe when air quality is lousy
                                                      • Best ways to limit your pollutant exposure
                                                      • Related Readings:

                                                        • Can air pollution negate the health benefits of cycling and walking?
                                                        • Air Pollution–Mediated Susceptibility to Inflammation and Insulin Resistance: Influence of CCR2 Pathways in Mice
                                                        • Should You Stop Exercising During Wildfire Season?
                                                        • Ambient Particulate Air Pollution and Daily Mortality in 652 Cities
                                                        • Companies/Products Mentioned:

                                                          • Plume Labs
                                                          • IQAir
                                                          • Blue Air
                                                          • Bios:

                                                            Paul Kedrosky is a frequently injured athlete who, when he isn't rehabbing, is also a venture investor. Howard Luks is a top sports orthopedic surgeon.

                                                            Music & Disclaimers:

                                                            • Crossing the Chasm Kevin MacLeod Licensed under Creative Commons: By Attribution 3.0 http://creativecommons.org/licenses/by/3.0/
                                                            • Wholesome by Kevin MacLeod Link: https://incompetech.filmmusic.io/song/5050-wholesome License: http://creativecommons.org/licenses/by/4.0/
                                                            • Disclaimers apply and can be heard at the end of the episode.

                                                              29 min
                                                            • Lifespan & Healthspan: The Science(s) of Healthier Aging, From Cells to Centenarians

                                                              Paul and Howard talk about healthy aging, from cell death, to diet, to centenarians, and exercise in-between. Financial geek that he is, Paul sneaks in a little riff about pension fraud too. There is a fairly crap transcript here.

                                                              Topics:

                                                              • Healthspan vs lifespan, squaring the curve
                                                              • Cellular housekeeping and whether it can be catalyzed
                                                              • Diets -- good, bad, and simple
                                                              • What we can learn from centenarian studies, and where are their flaws
                                                              • Readings and Books Mentioned:

                                                                • Muscle mass and longevity
                                                                • Squaring off the lifespan curve 
                                                                • Metabolic health and our muscles, tendons, and joints
                                                                • Supercentenarian and remarkable age records exhibit patterns indicative of clerical errors and pension fraud
                                                                • Bios:

                                                                  Paul Kedrosky is a frequently injured athlete who, when he isn't rehabbing, is also a venture investor. Howard Luks is a top sports orthopedic surgeon.

                                                                  Music & Disclaimers:

                                                                  • Crossing the Chasm Kevin MacLeod Licensed under Creative Commons: By Attribution 3.0 http://creativecommons.org/licenses/by/3.0/
                                                                  • Disclaimers apply and can be heard at the end of the episode.

                                                                    32 min

                                                                  About Simplavida: Simplified Longevity

                                                                  From the publisher's feed

                                                                  Simplifying health, fitness, exercise, Zone 2, and longevity, with your hosts Dr. Paul Kedrosky and Howard Luks, MD. Paul Kedrosky is a frequently injured athlete who, when he isn’t rehabbing, is also a venture investor. Howard Luks is a top sports orthopedic surgeon.

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