When initial treatment with varenicline or nicotine replacement doesn't work, does increasing dosage improve smoking cessation rates? Paul Cinciripini, PhD, of MD Anderson Cancer Center's Department of Behavioral Science, joins JAMA Executive Editor Gregory Curfman, MD, to discuss guidance on the best strategies for smoking cessation following an initial quit attempt. Related Content:

• Smoking Cessation After Initial Treatment Failure With Varenicline or Nicotine Replacement