What began as intermittent rashes that popped up years apart turned into excruciating, long term flare ups with no reprieve for Kristen Willard. Unable to sleep, shower, or even put on pants - Kristen’s quality of life plummeted. With no common trigger to explain the debilitating flares, she was forced to endure for months on end without relief. After decades and at the end of her rope, Kristen seeks answers one last time. 

We want to hear from you! Share your own medical mystery or tell us about the episode you connected with the most at [email protected] or drop us a voice note at https://www.speakpipe.com/Symptomatic . 

DISCLAIMER: By submitting your voice note using the link provided, you acknowledge that we have permission to potentially include that audio in future content.

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You can learn more about Chronic Spontaneous Urticaria at chronic-urticaria.org and you can find the Global Allergy & Airways Patient Platform at gaapp.org.

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Rockstar Casey McPherson and his family were shocked to the core when his daughter Rose was diagnosed with a rare genetic mutation that has no known treatment. Faced with the possibility of losing his daughter, the front man of the Flying Colours dropped everything to devote his life to trying to find a cure before time runs out.

We want to hear from you! Share your own medical mystery or tell us about the episode you connected with the most at [email protected] or drop us a voice note at https://www.speakpipe.com/Symptomatic. 

DISCLAIMER: By submitting your voice note using the link provided, you acknowledge that we have permission to potentially include that audio in future content.

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You can learn more about AlphaRose at https://www.alpharose.com/, To Cure A Rose Foundation at www.tocurearose.org and TCAR RareLabs at https://www.tcarrarelabs.org/.

You can follow Casey @casey.mcpherson on instagram. 

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For as long as Cienna Ditri can remember, she has had random bouts of “heavy legs”and loss of vision. As she got older - that sensation grew into episodes in which she could not move altogether. Cienna was passing out multiple times a day and frequently losing vision. After a slew of misdiagnoses - she was unsure she would ever understand the cause…until one doctor found the needle in the haystack.

We want to hear from you! Share your own medical mystery or tell us about the episode you connected with the most at [email protected] or drop us a voice note at https://www.speakpipe.com/Symptomatic. 

DISCLAIMER: By submitting your voice note using the link provided, you acknowledge that we have permission to potentially include that audio in future content.

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You can learn more about Periodic Paralysis at periodicparalysis.org

You can follow Cienna at @chronicallyperservering on instagram, tiktok, facebook, and youtube.

You can find Cienna’s substack “In Rare Form” at chronicallypersevering.substack.com

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Ian Stedman suffered 32 years with full body rashes, debilitating headaches, joint pain and hearing loss without a clear diagnosis. His Mother Barb had gone over 60 years with the same symptoms. After hundreds of doctors visits and decades of frustration - they had resigned to believe there were no answers. That is until Ian’s daughter, Lia was born covered in that all-too-recognizable rash. Ian re-ignited his search for answers in an effort to save his family. 

We want to hear from you! Share your own medical mystery or tell us about the episode you connected with the most at [email protected] or drop us a voice note at https://www.speakpipe.com/Symptomatic. 

DISCLAIMER: By submitting your voice note using the link provided, you acknowledge that we have permission to potentially include that audio in future content.

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You can learn more about the Canadian Autoinflammatory Network at www.autoinflammatory.ca

SickKids CA can be found online at www.sickkids.ca

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From the moment Hailey got her period, she could tell that something was different about her. Suffering debilitating menstrual cramps and a flow so heavy she would pass out from blood loss…Hailey spent half of every month fighting to stand up. When she joined the Air Force as a medic, Hailey did not predict how agonizing her symptoms would become… and how harrowing her journey to a diagnosis would be as a woman in a male dominated field. 

We want to hear from you! Share your own medical mystery or tell us about the episode you connected with the most at [email protected] or drop us a voice note at https://www.speakpipe.com/Symptomatic. 

DISCLAIMER: By submitting your voice note using the link provided, you acknowledge that we have permission to potentially include that audio in future content.

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You can find Hailey on tik tok @Hailey_griffith

You can follow Dr. Lucky Sekhon @lucky.sekhon and look out for her new book, “The Lucky Egg”, releasing on January 13th, 2026.

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Nika spent half her life battling a shape-shifting condition that plagued her in various ways for nearly two decades. Fighting chronic pain, fevers, fatigue, and even strokes. In her 30s, after a series of lymphoma scares, Nika thought she was going to die without answers. But, 17 years, 26 doctors and 37 procedures later - Nika was finally able to name her faceless foe.

We want to hear from you! Share your own medical mystery or tell us about the episode you connected with the most at [email protected] or drop us a voice note at https://www.speakpipe.com/Symptomatic. 

DISCLAIMER: By submitting your voice note using the link provided, you acknowledge that we have permission to potentially include that audio in future content.

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To find out more about IgG4-RD, you can check out IgG4ward! Foundation’s website at https://igg4ward.org/

You can also find Nika Beamon on her website here.

See omnystudio.com/listener for privacy information.

New season. New mysteries. Host Lauren Bright Pacheco returns to uncover the hidden truths behind chronic and rare illnesses. These are the stories of symptoms that defy explanation and the people who refuse to give up. Look out for new episodes of Symptomatic starting November 4th!

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We’re celebrating Dr. David Fajgenbaum and revisiting one of our most impactful stories. David was just named to the TIME100 Health list and has a powerful new TED Talk—milestones that reflect the empathy, curiosity, and determination at the heart of his work.

Once a college quarterback and competitive weightlifter, David became critically ill at 25. When standard treatments failed to keep him out of the ICU, he and his friend Grant raced to save his life by repurposing existing drugs and laying the foundation for Every Cure. His journey shows what’s possible when we ask tough questions, share our experiences, and refuse to give up.

We hope this re-release reminds each of us that we can make a difference—in our own lives and in the lives of others.

We’ll see you very soon for a brand-new season of Symptomatic. Until then, take care and be well.

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If you’re looking for information on Castleman disease or want to learn more about the work of Grant, David, and the Every Cure team, visit EveryCure.org

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Just when Trent starts to believe the worst is behind him, an unexpected twist turns his world upside down. He’s forced to confront new challenges that test his resilience and make decisions that could change the course of life for him and his family forever.

We want to hear from you! Share your own medical mystery or tell us about the episode you connected with the most at [email protected] or drop us a voice note at https://www.speakpipe.com/symptomatic.

DISCLAIMER: By submitting your voice note using the link provided, you acknowledge that we have permission to potentially include that audio in future content.

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To find out more about CIDP and Trent’s amazing story and advocacy at TrentFielder.com.

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Trent was a vibrant and successful insurance assessor when his life took an unexpected turn. While working under a car, he sensed something was off. It wasn’t until later that day -- when his legs stopped responding while driving -- that the severity of the situation hit him. What followed was a baffling health crisis that turned his world upside down. With two newborn twins at home, Trent's sudden immobility brought his worst fears to life.

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To find out more about CIDP and Trent’s amazing story and advocacy at TrentFielder.com.

See omnystudio.com/listener for privacy information.