Is it too late to stop criminals and American adversaries from exploiting AI to conduct cyberattacks or design novel pathogens? Has regulation kept pace with the threat civilian drones pose to critical infrastructure? AI researcher Lennart Heim, Army drone strategist Paul Lushenko, and CEO of Sentinel Bio Claire Qureshi join Jonathan to discuss the trade-offs between protecting the public and letting the private sector forge ahead. The conversation gets into synthetic DNA, the risk of drones at the FIFA World Cup, and whether the U.S. government should get early access to Silicon Valley's newest large language models.